Author(s): Samir Derouiche, Taissir Cheradid, Messaouda Guessoum

Email(s): dersamebio@gmail.com

DOI: 10.5958/2231-5713.2020.00033.1   

Address: Samir Derouiche*, Taissir Cheradid, Messaouda Guessoum
Department of Cellular and Molecular Biology, Faculty of the Sciences of Nature and Life, El-Oued University, El Oued 39000, El Oued, Algeria.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2020


ABSTRACT:
This review aims at identifying the role of oxidative stress and inflammation as factors associated with chronic kidney disease pathophysiology. some risk factorsof chronic kidney disease which can be non-modifiable including; age, gender, ethnicity and family history and may be modified by pharmacotherapy or lifestyle such as Diabetes, hypertension, inflammation, anemia. Oxidative stress is associated with kidney disease progression. Inflammation is a redox-sensitive mechanism able to activate transcriptor factors such as NF-kB, which regulates inflammatory mediator gene expression. There is a strong relationship between oxidative stress and inflammation in chronic kidney disease, both are related to endothelial dysfunction, and reactive oxygen species (ROS), lipid and protein oxidation products as well as advanced glycation end-products (AGEs) are generated in response to inflammatory stimuli.As a conclusion, oxidative stress and inflammation are essential factors in the development and complication of the CKD, and therefore it is necessary to take into account the mitigation of these two phenomena in any approved treatment program.We suggest also that exposure to heavy metals can negatively alter the function of the remaining functional nephrons, which can lead to faster and additional cell death and glomerulosclerosis and from it to chronic renal failure.


Cite this article:
Samir Derouiche, Taissir Cheradid, Messaouda Guessoum. Heavy metals, Oxidative stress and Inflammation in Pathophysiology of Chronic Kidney disease - A Review. Asian J. Pharm. Tech. 2020; 10(3):202-206. doi: 10.5958/2231-5713.2020.00033.1


REFERENCE: 
1. Robert T, Abbas K, John RS. Chronic Kidney Disease and Its Complications. Prim Care Clin Office Pract2008; 35: 329–344.
2. Angela CW, Evi VN, Rachael LM, Philip M. Chronic Kidney Disease. Elsevier Ltd, 2016; 389(10075).
3. Sung KC, Ryu S, Lee JY, Lee SH, Cheong E, Hyun YY, Lee KB, Kim H, Byrne CD. Urine Albumin/Creatinine Ratio Below 30 mg/g is a Predictor of Incident Hypertension and Cardiovascular Mortality. J Am Heart Assoc. 2016;5(9): e003245.
4. Claudio R, Lakhmir SC. Glomerular Filtration Rate, Renal Functional Reserve, and Kidney Stress Testing. Critical Care Nephrology (Third Edition).2019; 48-59.e2
5. Kent TL, Bagby SP, Giraud GD. Maternal Adaptations to Pregnancy. Knobil and Neill’s Physiology of Reproduction, 4th Eds. 2015; 1927–1955.
6. Perkins RM, Kirchner HL, Hartle JE, Bucaloiu ID. Estimated glomerular filtration rate variability and risk of end-stage renal disease among patients with Stage 3 chronic kidney disease. ClinNephrol. 2013;80(4):256-62.
7. Legrand M, Payen D. Understanding urine output in critically ill patients. Legrand and Payen. Ann Intensive Care. 2011;1(1):13. 
8. Kazancioğlu R. Risk factors for chronic kidney disease: an update. Kidney Int Suppl (2011). 2013;3(4):368-371. 
9. Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 2015;30(1):11-26. 
10. Derouiche S, Degachi O, Gharbi K. Phytochemistry analysis and modulatory activity of Portulacaeoleracea and Aquilariamalaccensis extracts against High-fructose and high-fat diet induced immune cells alteration and heart lipid peroxidation in Rats. International Research Journal of Biological Sciences. 2019; 8(4): 6-11.
11. Atieh M, Mohsen N, Zahra S. Oxidative Stress in Chronic Kidney Disease. Iranian journal of kidney diseases (IJKD), 2015; 9: 165-79.
12. Levin A. Identification of patients and risk factors in chronic kidney disease--evaluating riskfactors and therapeutic strategies. Nephrol Dial Transplant. 2001;16 Suppl 7:57-60.
13. Sadia H, Rabia T, Fatima, A., and Tahir, M. (2012). Modifiable and Non-modifiable predisposing Risk Factors of Myocardial Infarction -A Review. Journal of Pharmaceutical Sciences and Research, 4(1), 1649-1653.
14. Carlos MO, Raúl H, Miguel A, Elsy GB, Carlos EH, Héctor B, Juan CA, Denis JC, Patricia O, Rosa MC, María EV, Sonia GN, Verónica MC, Bertha EC. Chronic Kidney Disease and Associated Risk Factors in the BajoLempa Region of El Salvador: Nefrolempa Study, 2009. MEDICC Review, 2011; 13(4): 14-22.
15. Derouiche S, Zeghib K, Gharbi S, Khelef Y. Ameliorative effect of Aristolochia longa and Aquilariamalaccensis on lead acetate induced nephrotoxicity in female rats. International Journal of Biological and Agricultural 2018; 1(2): 1-13.
16. Emmanuel E, Pierre MG, Perrodin Y. Groundwater contamination by microbiological and chemical substances released from hospital wastewater and health risk assessment for drinking water consumers. Environ. Int. 2009; 35: 718-726.
17. Muhammad S, Shah MT, Khan S. Health risk assessment of heavy metalsand their source apportionment in drinking water of Kohistan region, northern Pakistan. Microchem. J. 2011; 98: 334-343.
18. Rapant S, Krcmova K. Health risk assessment maps for arsenic groundwatercontent, application of national geochemical databases. Environ. Geochem. Health, 2007; 29: 131-141.
19. Hsu RK, Hsu CY. The Role of Acute Kidney Injury in Chronic Kidney Disease. SeminNephrol. 2016;36(4):283-92. 
20. Anderson S1, Halter JB, Hazzard WR, Himmelfarb J, Horne FM, Kaysen GA, Kusek JW, Nayfield SG, Schmader K, Tian Y, Ashworth JR, Clayton CP, Parker RP, Tarver ED, WoolardNF.Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am SocNephrol. 2009 Jun;20(6):1199-209. 
21. Chapter 1: Definition and classification of CKD. Kidney Int Suppl (2011). 2013 Jan;3(1):19-62.
22. Daenen K, Andries A, Mekahli D, Van Schepdael A, Jouret F, Bammens B. Oxidative stress in chronic kidney disease.Pediatr Nephrol. 2019 Jun;34(6):975-991.
23. Kristien D, Asmin A, Djalila M, Ann VS, François J, Bert B. Oxidative stress in chronic kidney disease. Pediatric Nephrology. Aust N Z J Med. 2018; 10(3): 340-345.
24. Agarwal R. Pro-inflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockade. Am J Physiol Renal Physiol, 2003; 284: 863–869.
25. Ratliff BB, Abdulmahdi W, Pawar R, Wolin MS. Oxidant Mechanisms in Renal Injury and Disease. Antioxid Redox Signal. 2016; 25(3):119-46.
26. Zebidi M, Seghiri I, Mehellou Z, Derouiche S. Evaluation of Antioxidant and Antidiabetic activity of leave aqueous extracts of Oudneya Africana. World J PharmSci 2018; 6(5): 48-53.
27. Davis RM, Niu TSM. Oxidative Stress and AntioxidantTreatment in Hypertension and the Associated Renal Damage. Am J Nephrol, 2005; 25: 311–317.
28. Derouiche S, Serouti A, Rezzagmohcen O S. Risk of Metribuzin (Triazinone herbicide) on hematological and renal structure and function of pregnancy rabbits. AsianJ.Biol. Sci. 2019; 12:192-198.
29. Locatelli F, Bernard C, Kai-Uwe E, Peter S, Christoph W, Carmine Z. Oxidative stress in end-stage renal disease: an emerging threat to patient outcome. Nephrol Dial Transplant, 2003; 18: 1272–1280.
30. Ling XC, Kuo K. Oxidative stress in chronic kidney disease. Ren Replace Ther 2018; 4: 53.
31. Derouiche S, Atoussi N, Guediri S. Assessment of Hematological Parameters, Enzymes Activities, and Oxidative Stress Markers in Salivary and Blood of Algerian Breast Cancer Patients Receiving Chemotherapy. Biochem Tech 2019; (4): 50-58.
32. Victoria C, Marian G, Soledad G-V, Pilar O, Vicente L, Jose L. Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney International, 2008; 74(111): 4–9.
33. Vassilis F, Dimitrios H, Lambrini T, Polixeni M, Vasilis S, Dimosthenis V. Inflammation and oxidative stress in end-stage renal disease patients treated with hemodialysis or peritoneal dialysis. The International Journal of Artificial Organs, 2009; 32(12): 872-882.
34. Spittle MA, Hoenich NA, Handelman GJ, Adhikarla R, Homel P, Levin NW. Oxidative stress and inflammation in hemodialysis patients. Am J Kidney Dis, 2001; 38: 1408.
35. Kany S, Vollrath JT, Relja B. Cytokines in Inflammatory Disease. Int J Mol Sci. 2019; 20(23):6008. 
36. Mezzano D, Pais EO, Aranda E, et al. Inflammation, not homocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia. Kidney Int, 2001; 60: 1844-1850.
37. Singh R, Gautam N, Mishra A, Gupta R. Heavy metals and living systems: An overview. Indian J Pharmacol. 2011;43(3):246-53. 
38. Tutic A, Novakovic S, Lutovac M, Biocanin R, Ketin S, Omerovic N. The Heavy Metals in Agrosystems and Impact on Health and Quality of Life. Open Access Maced J Med Sci. 2015;3(2):345-55. 
39. Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN. Toxicity, mechanism and health effects of some heavy metals. InterdiscipToxicol. 2014;7(2):60-72. 
40. Djouadi A, Derouich S. Study of fluoride-induced haematological alterations and liver oxidative stress in rats. World J. Pharm. Pharm. Sci. 2017; 6(5): 211-221.
41. Huang YC, Ning HC, Chen SS, Lin CN, Wang IK, Weng SM, Weng CH, Hsu CW, Huang WH, Lu JJ, Wu TL, Yen TH. Survey of urinary nickel in peritoneal dialysis patients. Oncotarget. 2017;8(36):60469-60478. 
42. Makris K, Spanou L. Acute Kidney Injury: Diagnostic Approaches and Controversies. Clin BiochemRev. 2016;37(4):153-175. 
43. Hfaïedh, N., Allaqui, M.S., Croute, F., Soleilhavoup, J.P., Jammoussi, K., MakniAyadi, F., Kammoun, A, El Feki A. Interaction du jeûne intermittent sur les effets cytotoxiques rénaux du nickel chez le rat pubère. Comptes Rendus Biologies, 2005; 328(7): 648–660. 
44. Obone E, Chakrabarti SK, Bai C, Kalick MA. (). Toxicity and Bioaccumulation of Nickel Sulfate In Sprague-Dawley Rats Following 13 Weeks Of Subchronic Exposure. Journal of Toxicology and Environmental Health, 1999; 57(6): 379–401.
45. Derouiche S, Zeghib K. Evaluation of the Chelating Efficacy of Aquilariamalaccensis and Aristolochia longa Against Biochemical Alterations Induced by Lead Bioaccumulation in Rats. Pharmaceutical and Biosciences Journal 2019; 7(2): 11-15.
46. Sharma B, Singh S, Siddiqi NJ. Biomedical implications of heavy metals induced imbalances in redox systems. BiomedRes Int. 2014; 2014:640754. 
47. Haque SK, Ariceta G, Batlle D. Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies. Nephrol Dial Transplant. 2012;27(12):4273-87. 
48. Chang JC, Kou SJ, Lin WT, Liu CS. Regulatory role of mitochondria in oxidative stress and atherosclerosis. World J Cardiol. 2010;2(6):150-9. 
49. Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A. Tubulo-interstitial nephritis: diagnosis, treatment, and monitoring. PediatrNephrol. 2017;32(4):577-587.
50. Eirin A, Lerman A, Lerman LO. The Emerging Role of Mitochondrial Targeting in Kidney Disease. Handb Exp Pharmacol. 2017; 240: 229-250. 
51. Fevrier-Paul A, Soyibo AK, Mitchell S, Voutchkov M. Role of Toxic Elements in Chronic Kidney Disease. J Health Pollut. 2018;8(20):181202. 
52. Bridges CC, Zalups RK. The aging kidney and the nephrotoxic effects of mercury. J Toxicol Environ Health B CritRev. 2017;20(2):55-80. 
53. Mi RC, Hwan GK, Sang-Hee J, Myung HC. Time-dependent Changes of Cadmium and Metallothionein after Short-term Exposure to Cadmium in Rats. ToxicolRes 2010; 26:131−136.
54. López-Novoa JM, Rodríguez-Peña AB, Ortiz A, Martínez-Salgado C, López Hernández FJ. Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications. J Transl Med. 2011; 9:13. 
55. Vaidya VS, Ferguson MA, Bonventre JV. Biomarkers of acute kidney injury. AnnuRevPharmacolToxicol. 2008; 48:463-93. 
56.   Argyropoulos CP, Chen SS, Ng YH, Roumelioti ME, Shaffi K, Singh PP, Tzamaloukas AH. Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases. Front Med (Lausanne). 2017; 4:73.

Recomonded Articles:

Author(s): Juveriya Fatima, Saniya Khan, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00009.5         Access: Open Access Read More

Author(s): Yogita. Chowdhary

DOI: 10.5958/2231-5713.2018.00002.8         Access: Open Access Read More

Author(s): Anju govind, Manjunath B Menden, Ravikumar, Simila1, Mercy, Narayana Swamy VB

DOI: 10.5958/2231-5713.2016.00013.1         Access: Open Access Read More

Author(s): Debarshi Kar Mahapatra , Ruchi S. Shivhare , Vinod G. Ugale

DOI: 10.5958/2231-5713.2018.00008.9         Access: Open Access Read More

Author(s): Prajapati Krishna V., Jain Vinit C., Prajapati Neelam

DOI: 10.5958/2231-5713.2016.00007.6         Access: Open Access Read More

Author(s): Brijesh Kumar Saroj, Shreyash Tripathi, Mohd Yaqub Khan

DOI: 10.5958/2231-5713.2018.00034.X         Access: Closed Access Read More

Author(s): Patel D.S. , Shah P. B. , Managoli N. B.

DOI:         Access: Open Access Read More

Author(s): Nitin Mahurkar, S.M Sayeed Ul Hasan, Syed Mutool Quadri

DOI:         Access: Open Access Read More

Author(s): S.K. Purohit, R. Solanki, R. Soni, V. Mathur

DOI:         Access: Open Access Read More

Author(s): R. Solanki, B.P. Nagori

DOI:         Access: Open Access Read More

Author(s): Priyanka V Dhalkar, Shivani S Jagtap, Suraj T Jadhav, Myuresh R. Redkar., Biradev S Karande

DOI: 10.5958/2231-5713.2019.00034.5         Access: Closed Access Read More

Author(s): Samir Derouiche, Taissir Cheradid, Messaouda Guessoum

DOI: 10.5958/2231-5713.2020.00033.1         Access: Closed Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags