Nikita Kumawat, Jidnyasa Pantwalawalkar, Yogini Vispute, Rahul Tade, Sopan Nangare
Nikita Kumawat1, Jidnyasa Pantwalawalkar2, Yogini Vispute1, Rahul Tade3, Sopan Nangare3*
1Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425405, Dist- Dhule (MS), India.
2Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, 416013, Dist- Kolhapur (MS), India.
3Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425405, Dist- Dhule (MS), India.
Volume - 11,
Issue - 2,
Year - 2021
Aegle marmelos (A. marmelos Corr., Rutaceace) known as bael is found from pre-historic time. It belongs of Indian origin. It has abundant allegorical importance for Hindus. A. marmelos is available in diverse varieties viz. Pant Aparna, Pant Urvashi, Narendra bael-5, Narendra bael-6, Pant Sujata, Pant Shivani, CISHB-1, CISHB-2, etc. Wholly parts of the A. marmelos tree have medicinal values and have been used as medicine for a long time. A. marmelos has different classes of compounds including coumarins, alkaloids, terpenoids, fatty acids, amino acids, etc. This plant has a strong potential to treat diseases including diarrhea, dysentery, anti-bacterial, anti-fungal, diabetes, peptic ulcer, inflammation, etc. Besides, it provided anticancer, cardio-protective, antipyretic, analgesic, constipation, antioxidant, wound healing activity. The gum obtained from bael fruits has great potential in sustaining the delivery of the drug. The marketed products of A. marmelos are Chyawanprash, A. marmelos capsules, Capsule Bilv Giri, Entrostat Syrup, Ojamin, Vilwadigulika, etc. Other products made from fruit are jam, slab, dehydrated bael, fruit squash, fruit pulp Bael powder, toffee, and ready to serve (RTS) drink. Recently lots of work on different parts of bael has been establishing scientific proof for its traditional claims. Hence, it is essential to compile the current findings along with the preceding work, which will assist the researchers to find all the literature on A. marmelos. Overall, the present overview deals with general, traditional, phytopharmaceutical, pharmacological, chemical profile, and economic importance like pharmaceutical and other applications.
Cite this article:
Nikita Kumawat, Jidnyasa Pantwalawalkar, Yogini Vispute, Rahul Tade, Sopan Nangare. An Overview on Phytochemistry, Pharmacology, Pharmaceutical, Traditional and Economical Aspects of Aegle marmelos. Asian Journal of Pharmacy and Technology. 2021; 11(2):166-4. doi: 10.52711/2231-5713.2021.00028
Nikita Kumawat, Jidnyasa Pantwalawalkar, Yogini Vispute, Rahul Tade, Sopan Nangare. An Overview on Phytochemistry, Pharmacology, Pharmaceutical, Traditional and Economical Aspects of Aegle marmelos. Asian Journal of Pharmacy and Technology. 2021; 11(2):166-4. doi: 10.52711/2231-5713.2021.00028 Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-2-13
1. Verma S, Rani R, Vashishth E, Basu K, Pant P, Padhi M. Simple, Rapid and Precise Method for Quality Assessment of Different Parts of Aegle marmelos L. used in Indian System of Medicine. Research Journal of Pharmacognosy and Phytochemistry. 2013;5(5): 236-243.
2. Mali SS, Dhumal RL, Havaldar VD, Shinde SS, Jadhav NY, Gaikwad BS. A Systematic Review on Aegle marmelos (Bael). Research Journal of Pharmacognosy and Phytochemistry. 2020;12(1): 31-36.
4. Singh S. Standardization of processing technology of bael (Aegle marmelos Correa). In.: Chaudhary Charan Singh Haryana Agricultural University; Hisar; 2003.
5. Agarwal V. Rural economics of medicinal plants: vegetation in the forests. Drug Plants of India. 1997;1: 1-6.
6. Singh A, Sharma H, Kaushal P, Upadhyay A. Bael (Aegle marmelos Correa) products processing: A review. African J Food Sci. 2014;8: 204-215.
7. Parichha S. Bael (Aegle marmelos): Nature's most natural medicinal fruit. Orissa Review. 2004;9: 16-17.
8. Sharma PC, Bhatia V, Bansal N, Sharma A. A review on Bael tree. 2007.
9. Meena AK, Sehgal H, Rao M, Panda P, Padhi M. Ayurvedic, Phytochemical and Pharmacological profile of Aegle marmeolus (Linn.) Corrae-A Review. Research Journal of Pharmacology and Pharmacodynamics. 2011;3(6): 340-344.
10. Chadha K. Handbook of horticulture. Handbook of Horticulture. 2001.
11. Neeraj VB, Johar V. Bael (Aegle marmelos) extraordinary species of India: a review. Int J Curr Microbiol App Sci. 2017;6(3): 1870-1887.
12. Dhankhar S, Ruhil S, Balhara M, Dhankhar S, Chhillar A. Aegle marmelos (Linn.) Correa: A potential source of Phytomedicine. J Med Plant Res. 2011;5(9): 1497-1507.
13. Sharma G, Dubey S. Medicinal values of Bael: A review. Int J Cur Pharm Rev Res. 2005;1(3): 20-31.
14. Lambole V, Murti K, Kumar U, Bhatt S, Gajera V. Phytopharmacological properties of Aegle marmelos as a potential medicinal tree: an overview. Int J Pharm Sci Rev Res. 2010;5(2): 67-72.
15. Orwa C. An Introduction to Aegle marmelos. Agro Data. 2009;4(2): 1-5.
16. Purohit S, Vyas S. In: Aegle marmelos Correa ex Roxb, (Bael), Medicinal plant cultivation-A scientific approach. Agrobios, Jodhpur. 2004: 498-504.
17. Shankar G, Garg K. Nutritional value of some important fruits. Handbook of Horticulture, Kitabistan, Allahabad. 1967: 37-41.
18. Patkar A, Desai N, Ranage A, Kalekar K. A review on Aegle marmelos: a potential medicinal tree. International Research Journal of Pharmacy. 2012;3(8): 86-91.
19. Charoensiddhi S, Anprung P. Bioactive compounds and volatile compounds of Thai bael fruit (Aegle marmelos (L.) Correa) as a valuable source for functional food ingredients. International food Research Journal. 2008;15(3): 287-295.
20. Mandal PK, Mukherjee AK. Structural investigations on bael exudate gum. Carbohydrate Research. 1980;84(1): 147-159.
21. Varshosaz J, Tavakoli N, Eram SA. Use of natural gums and cellulose derivatives in production of sustained release metoprolol tablets. Drug Delivery. 2006;13(2):113-119.
22. Udeala O, Chukwu A. The binding property of mucuna gum in sulphadimidine and chloroquine phosphate tablets. Nigeria Journal of Pharmaceutical Sciences. 1985;1: 59-66.
23. Olorunsola EO, Adedokun MO. Surface activity as basis for pharmaceutical applications of hydrocolloids: A review. Journal of Applied Pharmaceutical Science. 2014;4(10): 110-116.
24. Vendruscolo CW, Ferrero C, Pineda EA, Silveira JL, Freitas RA, Jiménez-Castellanos MR, Bresolin TM. Physicochemical and mechanical characterization of galactomannan from Mimosa scabrella: Effect of drying method. Carbohydrate Polymers. 2009;76(1): 86-93.
25. Patil D, Kulkarni A, Patil B. Fruit gum of Aegle marmelos as pharmaceutical aid. IJP-International Journal of Pharmacology. 2010;6(1): 68-71.
26. Mahammed N, Gowda D, Deshpande RD, Thirumaleshwar S. Design of phosphated cross-linked microspheres of bael fruit gum as a biodegradable carrier. Archives of Pharmacal Research. 2015;38(1): 42-51.
27. Chakraborty J, Dash S, Das B. Formulation and evaluation of controlled release mucoadhessive matrix tablets of levamisole: assement of purified fruit pulp polysaccharide isolated from aegle marmelos as mucoadhesive excipient. Asian J Pharm Clin Res. 2015;8(4): 262-269.
28. Gurjar PS, Lal N, Gupta AK, Marboh ES. A Review on medicinal values and commercial utility of Bael. International Journal of Life-Sciences Scientific Research. 2015;1(1): 5-7.
29. Alagumuthu G, Kirubha R. Biogenic Synthesis of Silver Nanoparticles using Aegle marmelos fruit extract and their Antibacterial potential. Asian Journal of Research in Chemistry. 2013;6(9): 839-844.
30. Manjula A, Kumar PS. In vitro Evaluation of Biological Activity of Aegle marmelos (L.) Fruit. Research Journal of Pharmacy and Technology. 2016;9(4): 407-414.
31. Ansary P. A hand book on the plant sources of indigenous drugs: International Book Distributors; 2005.
32. Baliga MS, Bhat HP, Pereira MM, Mathias N, Venkatesh P. Radioprotective effects of Aegle marmelos (L.) Correa (Bael): a concise review. The Journal of Alternative and Complementary Medicine. 2010;16(10): 1109-1116.
33. Jyothi KS, Rao BS. Antibacterial activity of extracts from Aegle marmelos against standard pathogenic bacterial strains. International Journal of Pharmtech Research. 2010; 2(3): 1824-1826.
34. Mazumder R, Bhattacharya S, Mazumder A, Pattnaik A, Tiwary P, Chaudhary S. Antidiarrhoeal evaluation of Aegle marmelos (Correa) Linn. root extract. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2006;20(1): 82-84.
35. Dhuley J. Investigation on the gastroprotective and antidiarrhoeal properties of Aegle marmelos unripe fruit extract. Hindustan Antibiotics Bulletin. 2003;45(1-4): 41-46.
36. Tiku AB, Abraham SK, Kale RK. Eugenol as an in vivo radioprotective agent. Journal of Radiation Research. 2004;45(3): 435-440.
37. Lampronti I, Martello D, Bianchi N, Borgatti M, Lambertini E, Piva R, Jabbar S, Choudhuri MSK, Khan MTH, Gambari R. In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa. Phytomedicine. 2003;10(4): 300-308.
38. Agrawal A, Jahan S, Soyal D, Goyal E, Goyal PK. Amelioration of chemical-induced skin carcinogenesis by Aegle marmelos, an Indian medicinal plant, fruit extract. Integrative Cancer Therapies. 2012;11(3): 257-266.
39. Rahman S, Parvin R. Therapeutic potential of Aegle marmelos (L.)-An overview. Asian Pacific Journal of Tropical Disease. 2014;4(1): 71-77.
40. Vyas A, Bhargava S, Bhargava P, Shukla S, Pandey R, Bhadauria R. Evaluation of antipyretic potential of Aegle marmelos (L.) Correa leaves. Oriental Journal of Chemistry. 2011; 27(1): 253.
41. Goel R, Maiti R, Manickam M, Ray A. Antiulcer activity of naturally occurring pyrano-coumarin and isocoumarins and their effect on prostanoid synthesis using human colonic mucosa. Indian Journal of Experimental Biology. 1997;35(10): 1080-1083.
42. Madhu C, Hindu K, Sudeepthi C, Maneela P, Reddy KV, Sree BB. Anti ulcer activity of aqueous extract of Aegle marmelos leaves on rats. Asian Journal of Pharmaceutical Research. 2012;2(4): 132-135.
43. Ammar RB, Bouhlel I, Valenti K, Sghaier MB, Kilani S, Mariotte A-M, Dijoux-Franca M-G, Laporte F, Ghedira K, Chekir-Ghedira L. Transcriptional response of genes involved in cell defense system in human cells stressed by H2O2 and pre-treated with (Tunisian) Rhamnus alaternus extracts: Combination with polyphenolic compounds and classic in vitro assays. Chemico-Biological Interactions. 2007;168(3): 171-183.
44. Singh S, Singh SK, Srivastava S, Singh P, Trivedi M, Shanker P, Dixit R, Rana RS. Experimental evaluation of diuretic activity of Aegle marmelos in rats. Int J Pharm Biol Sci. 2013;3(1): 98-102.
45. Chauhan A, Agarwal M. Reversible changes in the antifertility induced by Aegle marmelos in male albino rats. Systems Biology in Reproductive Medicine. 2008;54(6): 240-246.
46. Ruhil S, Balhara M, Dhankhar S, Chhillar A. Aegle marmelos (Linn.) Correa: A potential source of Phytomedicine. Journal of Medicinal Plants Research. 2011;5(9): 1497-1507.
47. Rao CV, Ojha S, Amresh G, Mehrotra S, Pushpangadan P. Analgesic, antiinflammatory and antiulcerogenic activity of unripe fruits of Aegle marmelos. Acta Pharmaceutica Turcica. 2003;45: 85-91.
48. Gupta N, Agrawal R, Shrivastava V, Roy A, Prasad P. In vitro Antioxidant activity and phytochemical screening of Aegle marmelos extracts. Research Journal of Pharmacognosy and Phytochemistry. 2012;4(2): 80-83.
49. Urmi KF, Chowdhury AU, Diba F, Rahman KA, Habib R, Hamid K. Evaluation of Antioxidant and Cytotoxic Potential of Different Extracts from the Leaves of Aegle marmelos L. Research Journal of Pharmacy and Technology. 2013;6(4): 384-387.
50. Pande KH, Salve PS, Rai RK, Bali NR, Wankhede HS. Investigation and In vivo Demonstration of Synergistic Antidiabetic activity of Aqueous Extract of Aegle marmelos and Withania coagulans. Research Journal of Pharmacology and Pharmacodynamics. 2014;6(2): 101-107.
51. Upadhya S, Shanbhag KK, Suneetha G, Balachandra Naidu M, Upadhya S. A study of hypoglycemic and antioxidant activity of Aegle marmelos in alloxan induced diabetic rats. Indian J Physiol Pharmacol. 2004;48(4): 476-480.
52. Sabu M, Kuttan R. Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian Journal of Physiology and Pharmacology. 2004;48(1): 81-88.
53. Prince PSM, Rajadurai M. Preventive effect of Aegle marmelos leaf extract on isoprenaline‐induced myocardial infarction in rats: biochemical evidence. Journal of Pharmacy and Pharmacology. 2005;57(10): 1353-1357.
54. Singanan V, Singanan M, Begum H. The hepatoprotective effect of bael leaves (Aegle marmelos) in alcohol induced liver injury in albino rats. International Journal of Science & Technology. 2007;2(2): 83-92.
55. Patel P, Asdaq SMB. Immunomodulatory activity of methanolic fruit extract of Aegle marmelos in experimental animals. Saudi Pharmaceutical Journal. 2010;18(3): 161-165.
56. Kumar R, Kumar A, Prasal C, Dubey NK, Samant R. Insecticidal activity Aegle marmelos (L.) Correa essential oil against four stored grain insect pests. International Journal of Food Safety. 2008;10: 39-49.
57. Kumar DU, Maiti R, Jana D, Ghosh D. Effect of aqueous extract of leaf of Aegle marmelos on testicular activities in rats. 2006.
58. Jaswanth A, Loganathan V, Manimaran S. Wound healing activity of Aegle marmelos. Indian Journal of Pharmaceutical Sciences. 2001;63(1): 41.
59. Kothari S, Minda M, Tonpay SD. Anxiolytic and antidepressant activities of methanol extract of Aegle marmelos leaves in mice. Indian J Physiol Pharmacol. 2010;54(4): 318-328.
60. Sharma J, Painuli R, Gaur R. Plants used by the rural communities of district Shahjahanpur, Uttar Pradesh. 2010.
61. Rusia K, Srivastava S. Antimicrobial activity of some Indian medicinal plants. Indian Journal of Pharmaceutical Sciences. 1988;50(1):57.
62. Kruawan K, Kangsadalampai K. Antioxidant activity, phenolic compound contents and antimutagenic activity of some water extract of herbs. Thai J Pharm Sci. 2006;30: 28-35.
63. Maity P, Hansda D, Bandyopadhyay U, Mishra DK. Biological activities of crude extracts and chemical constituents of Bael, Aegle Marmelos (L.) Corr. 2009.
64. Yadav N, Singh P, Mehrotra R. Determination of some ethnomedicinally important constituents of Aegle marmelos fruit during different stages of ripening. Chinese Journal of Natural Medicines. 2011;9(3): 204-209.