Author(s): Dhivya S, Sukanya Gangopadhyay, Pradeep Kumar S, Gautam Sarkar

Email(s): sukanya.gangopadhyay@gmail.com

DOI: 10.5958/2231-5713.2020.00040.9   

Address: Dhivya S¹, Sukanya Gangopadhyay²*, Pradeep Kumar S³, Gautam Sarkar4
¹Senior Resident, Department of Biochemistry, VMMC and Safdarjung Hospital, New Delhi - 110029.
²Associate Professor, Department of Biochemistry, VMMC and Safdarjung Hospital, New Delhi - 110029,
Ex-Assistant Professor, Department of Biochemistry, Subharti Medical College, Meerut, Uttar Pradesh - 250005.
³Senior Resident, Department of GI Surgery, AIIMS, New Delhi – 110023.
4Ex-Professor and Head, Department of Biochemistry, Subharti Medical College, Meerut, Uttar Pradesh – 250005.
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2020


ABSTRACT:
Introduction: Hypothyroidism is a rising concern in India especially among women of all ages. Every year new cases are being diagnosed either independently or in combination with other medical and gynecological problems. With the further advent of our knowledge on hypothyroidism, it has been noticed that the renal function could be affected in such patients. Aim and objective: The aim of the present study was done to understand the effect of hypothyroidism on renal function in untreated or poorly treated hypothyroid subjects with the objective of comparing serum creatinine levels and estimated glomerular filtration rate (eGFR) in hypothyroid females with healthy age-matched controls. Materials and methods: Serum samples of 30 female patients received in our immunology lab with Thyroid Stimulating Hormone (TSH) more than 5mIU/L were analyzed for creatinine levels and the GFR was calculated concerning their age by using Modification of Diet in Renal Disease Study (MDRD) formula online. The same was repeated in 30 healthy female controls. Results and observations: The mean TSH value was significantly more in the cases (cases 8.15±2.5mIU/L; controls 3.11±0.88mIU/L; p-value < 0.0001) as purposefully high TSH samples were selected. Mean serum creatinine was significantly raised in the cases (cases 0.9±0.13mg/dl; controls 0.67±0.07mg/dl; p-value < 0.0001). The mean calculated GFR was 108.32±13.41mL/min/1.73m² in controls whereas in cases it was significantly low at 77.19±13.36mL/min/1.73m² (p-value < 0.0001). Conclusion: The mean serum creatinine was on the higher side of the normal range and mean calculated GFR was low in untreated or poorly treated hypothyroid females in Meerut, Uttar Pradesh. Hypothyroid women should regularly undergo renal assessment as a precautionary measure.


Cite this article:
Dhivya S, Sukanya Gangopadhyay, Pradeep Kumar S, Gautam Sarkar. Serum creatinine and eGFR are affected in female hypothyroid patients with poor Thyroid control. Asian J. Pharm. Tech. 2020; 10(4):241-244. doi: 10.5958/2231-5713.2020.00040.9


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