Author(s): Kalpak Gajbhiye, Nawaz Hakam, Gauri Rathod, Mukund Tawar

Email(s): gajbhiyekalpak@gmail.com

DOI: 10.52711/2231-5713.2021.00034   

Address: Kalpak Gajbhiye*, Nawaz Hakam, Gauri Rathod, Mukund Tawar
Department of Pharmaceutics, P.R. Pote College of Pharmacy, Kathora Road, Amravati – 444604 Maharashtra, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2021


ABSTRACT:
The present research was designed to evaluate matrix type Benidipine Hydrochloride transdermal patches. So, the present work is an attempt to study effect of variation in Methocel E15LV concentration and study effect of hydrophilic and hydrophobic Methocel E15LV and Eudragit RL100 combination on release profile of Benidipine Hydrochloride. All prepared formulations were evaluated for physical and mechanical properties like thickness, moisture uptake, percent flatness, tensile strength, and percent elongation. An attempt was made to get a patch with suitable drug release property as well as physical and mechanical properties. A formulation containing Methocel E15LV 2% has shown good physical, mechanical and in-vitro drug release properties. It also showed good diffusion of Benidipine Hydrochloride across goat skin.


Cite this article:
Kalpak Gajbhiye, Nawaz Hakam, Gauri Rathod, Mukund Tawar. Formulation and Evaluation of Transdermal Patches of Benidipine Hydrochloride. Asian Journal of Pharmacy and Technology 2021; 11(3):207-2. doi: 10.52711/2231-5713.2021.00034

Cite(Electronic):
Kalpak Gajbhiye, Nawaz Hakam, Gauri Rathod, Mukund Tawar. Formulation and Evaluation of Transdermal Patches of Benidipine Hydrochloride. Asian Journal of Pharmacy and Technology 2021; 11(3):207-2. doi: 10.52711/2231-5713.2021.00034   Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-3-4


REFERENCES:
1.    Dey BK, Kar PK, Nath LK. Formulation Design, Preparation and In vitro–In vivo Evaluation of Propranolol Hydrochloride Transdermal Patches using Hydrophilic and Hydrophobic Polymer complex. Research Journal of Pharmacy and Technology. 2009; 2(1): 155-60.
2.    Umekar MJ, Biyani DM, Amgaonkar YM, Bhoyar PK, Lade UB, Kalsait RP. Formulation Development and Evaluation of Transdermal Drug Delivery System of Antihypertensive Drug. Research Journal of Pharmacy and Technology. 2010 Jul; 3(3): 753-757.
3.    Choudhary S, Dharashivkar S, Mahajan C, Gaikwad M. Formulation and Evaluation of Nano-fiber-based Transdermal patch of Cephalexin. Research Journal of Pharmacy and Technology. 2020 Jun 1; 13(6): 2787-91.
4.    Jadhav YL, Parashar B, Ostwal PP, Jain MS. Solid Dispersion: Solubility enhancement for poorly water soluble drug. Research Journal of Pharmacy and Technology. 2012 Feb 1; 5(2):190.
5.    Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3): 4942-51.
6.    Madgulkar AR, Bhalekar MR, Kapse SB, Paygude BV, Reddi SS. Transdermal permeation enhancement of valsartan using solid lipid nanoparticles. Research Journal of Pharmacy and Technology. 2011; 4(8): 1297-302.
7.    Sharma D, Soni M, Kumar S, Gupta GD. Solubility enhancement—eminent role in poorly soluble drugs. Research Journal of Pharmacy and Technology. 2009 Apr; 2(2): 220-4.
8.    Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019 Dec 30;12(12): 5972-6.
9.    Ali S, Shabbir M, Shahid N. The structure of skin and transdermal drug delivery system-a review. Res. J. Pharm. Technol. 2015 Feb 28;8: 103-9.
10.    Shirsath SC, Patil PB, Mutha SS, Bhosale AV, Hardikar SR. A review of pluronic lecithin organogel (PLO) as a topical and transdermal drug delivery system. Research Journal of Pharmacy and Technology. 2009; 2(1):1-7.
11.    Sahu P, Sahu GK, Sharma H, Kaur CD. Formulation, Characterization and Ex vivo Evaluation of Epinephrine Transdermal Patches. Research Journal of Pharmacy and Technology. 2020 Apr 30; 13(4): 1684-92.
12.    Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31; 13(1): 4745-52.
13.    Suja C, Ramasamy C, Narayanacharyulu R. Development and evaluation of lisinopril transdermal patches. Research Journal of Pharmacy and Technology. 2011; 4(8): 1260-4.
14.    Stanekzai A, Sudhakar CK, Zhakfar AM, Karan VS. Recent approaches in transdermal drug delivery system. Research Journal of Pharmacy and Technology. 2019 Sep 1; 12(9): 4550-8.
15.    Bagyalakshmi J, Nipu SP, Ravi TK. Formulation and Evaluation of Chlorpheniramine Maleate from Methyl Cellulose Patches. Research Journal of Pharmacy and Technology. 2011; 4(6): 965-71.
16.    Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.
17.    Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2): 94-100.

Recomonded Articles:

Author(s): Wajid Ahmad, Jaza Quazi, Reshma Khan, Nadeem Ahmad, Nawed Ansari

DOI: 10.52711/2231-5713.2022.00023         Access: Open Access Read More

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): Poonam R. Songire, Smita S. Aher, R. B. Saudagar

DOI: 10.5958/2231-5713.2015.00031.8         Access: Open Access Read More

Author(s): Girishchandra R., Mandake, Shital S. Shinde, Vishal Y. Belaskar, Asha M. Jagtap, Ganesh B. Vambhurkar, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00033.8         Access: Open Access Read More

Author(s): Vanitha Kondi, Ramesh Alluri

DOI:         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): Godbole Ajeet Madhukar, Patel Bhautik V, Somnache Sandesh Narayan, Prajapati Ashish R, Yadav Pradeep

DOI: 10.5958/2231-5713.2017.00004.6         Access: Open Access Read More

Author(s): K. V. M. Krishna, V. Jagannadha Patro

DOI: 10.52711/2231-5713.2023.00005         Access: Closed Access Read More

Author(s): AVS Madhu Latha, T Naga Ravikiran, J N Suresh Kumar

DOI: 10.5958/2231-5713.2019.00001.1         Access: Open Access Read More

Author(s): Ankita R. Koshti, Sachin B. Jadhav, M. M. Bari, Dr. S. D. Barhate

DOI: 10.5958/2231-5713.2019.00036.9         Access: Open Access Read More

Author(s): Sachin B. Jadhav, Ankita R. Koshti, M. M. Bari, S. D. Barhate

DOI: 10.5958/2231-5713.2019.00037.0         Access: Open Access Read More

Author(s): Pooja Shetty, Ravi Kumar, Yamunappa, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/2231-5713.2016.00001.5         Access: Open Access Read More

Author(s): B. Ranga Nayakulu, Nakka Ravi Kumar, Ch. Kiran Kumar, P. Raja Abhilash

DOI: 10.5958/2231-5713.2016.00012.X         Access: Open Access Read More

Author(s): Subhashis Debnath, Gampa Vijay Kumar, S.V. Satyanarayana

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags