Author(s): Ayanam Vasavi, Miriyala Mrunalini, Ayanam Vasanthi, G. Raveendra Babu, M. Sowjanya

Email(s): vayinam@gmail.com

DOI: 10.52711/2231-5713.2022.00020   

Address: Ayanam Vasavi1*, Miriyala Mrunalini1, Ayanam Vasanthi1, G. Raveendra Babu2, M. Sowjanya3
1Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh.
2Department of Pharmaceutical Analysis, A.K.R.G. College of Pharmacy, Nallajerla, W.G. Dist., Andhra Pradesh.
3Department of Chemistry, Vijaya Teja Degree College, Addanki - 523201, Andhra Pradesh.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
As a novel drug delivery system, microspheres improve the efficacy of a drug, increase the time of action, lower the number of times in which a dosage form needs to be administered, and to increase patient compliance. Oral administration side effects such as gastric irritation are lessened through the use of microspheres. Ionotropic gelation was used to create HPMC K15M, Guar gum, and Carbopol 934 microspheres with different concentrations of Carbopol 934 polymer. Cross-linking was accomplished with the use of calcium chloride. In order to conduct a systematic evaluation of all the preparations, we performed various tests: morphology, FTIR, DSC, entrapment efficiency, size, microsphere size, and in-vitro drug release. The discrete, free-flowing, and spherical particles of prepared Stavudine microspheres were found. In compliance with standards, the mean particle size was in the range of 72.64 to 95.22 percent. In vitro drug release studies were performed in phosphate buffer solution with a pH of 6.8. As the concentration of sodium alginate and calcium chloride increased, the percentage of drug release was reduced. In the case of F9 formulation, which contained Stavudine, the decreased drug release rate was obtained via carbopol 934(1:3), sodium alginate, and calcium chloride. Conclusively, the present study shows that Stavudine microsphere preparation and formulation F9 are successful. Stavudine microspheres must be prepared in order to preserve an effective drug concentration in serum for a long time, while reducing gastrointestinal irritation.


Cite this article:
Ayanam Vasavi, Miriyala Mrunalini, Ayanam Vasanthi, G. Raveendra Babu, M. Sowjanya. Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method. Asian Journal of Pharmacy and Technology. 2022; 12(2):119-4. doi: 10.52711/2231-5713.2022.00020

Cite(Electronic):
Ayanam Vasavi, Miriyala Mrunalini, Ayanam Vasanthi, G. Raveendra Babu, M. Sowjanya. Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method. Asian Journal of Pharmacy and Technology. 2022; 12(2):119-4. doi: 10.52711/2231-5713.2022.00020   Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-2-6


REFERENCES:
1.    Nikam V, Gudoorkar V, Microspheres- A novel drug delivery system:an overview. Int J Pharma Chem Sci. 2012; 1(1):113-128.
2.    Kristmundsdottir T, Ingvarsdottir K. Ibuprofen microcapsules: the effect of production variables on microcapsule properties. Drug Development and Industrial Pharmacy. 1994;20(5):769–778.
3.    Capan Y, Jiang G, Giovagnoli S, Na K-H, DeLuca PP. Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of human growth hormone. AAPS PharmSciTech. 2003;4(2)
4.    Gohel MC, Amin AF. Formulation optimization of controlled release diclofenac sodium microspheres using factorial design. Journal of Controlled Release. 1998;51(2-3):115–122.
5.    Woo BH, Jiang G, Jo YW, DeLuca PP. Preparation and characterization of a composite PLGA and poly(acryloyl hydroxyethyl starch) microsphere system for protein delivery. Pharmaceutical Research. 2001;18(11):1600–1606.
6.    Davis SS, Illum L. Polymeric microspheres as drug carriers. Biomaterials. 1988;9(1):111–115.
7.    Ritschel WA. Biopharmaceutic and pharmacokinetic aspects in the design of controlled release peroral drug delivery systems. Drug Development and Industrial Pharmacy. 1989;15:1073–1103.
8.    Tripathi KD. Essentials of Medical Pharmacology. New Delhi, India: Jaypee Brothers’ Medical Publishers (P) Ltd; 2007.
9.    Martin AR. Antiviral Agents; Text Book of Organic Chemistry and Pharmaceutical Chemistry. New York, NY, USA: Lippincot-Reven; 1998.
10.    Lewis GA, Mathieu D, Phan-Tan-Luu R. Pharmaceutical Experimental Design. New York, NY, USA: Marcel Dekker; 1961.
11.    Singh B, Ahuja N. Book Review on Pharmaceutical experimental Design. 1999.
12.    Nelson KG, Wang LY. Determination of time course of tablet disintegration II: method using continuous functions. Journal of Pharmaceutical Sciences. 1978;67(1):86–89
13.    Singh B, Dahiya M, Saharan V, Ahuja N. Optimizing drug delivery systems using systematic ‘design of experiments.’ Part II: retrospect and prospects. Critical Reviews in Therapeutic Drug Carrier Systems. 2005;22(3):215–293.
14.    Singh B, Mehta G, Kumar R, Bhatia A, Ahuja N, Katare OP. Design, development and optimization of nimesulide-loaded liposomal systems for topical application. Current Drug Delivery. 2005;2(2):143–153.
15.    Aberturas MR, Molpeceres J, Guzmán M, García F. Development of a new cyclosporine formulation based on poly(caprolactone) microspheres. Journal of Microencapsulation. 2002;19(1):61–72.
16.    Kim CK, Kim MJ, Oh KH. Preparation and evaluation of sustained release microspheres of terbutaline sulfate. International Journal of Pharmaceutics. 1994;106(3):213–219.

Recomonded Articles:

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Phatak Atul A., Chaudhari Praveen D.

DOI:         Access: Open Access Read More

Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

DOI: 10.5958/2231-5713.2018.00001.6         Access: Open Access Read More

Author(s): Vanitha Kondi, Ramesh Alluri

DOI:         Access: Open Access Read More

Author(s): Chinmaya Keshari Sahoo, K. Satyanarayana, D. Venkata Ramana, Kanhu Charan Panda

DOI: 10.5958/2231-5713.2017.00034.4         Access: Open Access Read More

Author(s): Madan Singh, Prashant Soni, Neeraj Upmanyu , Yogesh Shivhare

DOI:         Access: Open Access Read More

Author(s): Girishchandra R. Mandake, Shital S. Shinde, Omkar A. Patil, Manojkumar M. Nitalikar

DOI: 10.5958/2231-5713.2018.00040.5         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): Himansu Bhusan Samal, Itishree Jogamaya Das, Ch. Niranjan Patra, P. N. Murthy

DOI: 10.5958/2231-5713.2015.00036.7         Access: Open Access Read More

Author(s): Girishchandra R., Mandake, Shital S. Shinde, Vishal Y. Belaskar, Asha M. Jagtap, Ganesh B. Vambhurkar, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00033.8         Access: Open Access Read More

Author(s): Chinmaya Keshari Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar, D. Venkata Ramana, K.Satyanarayana

DOI: 10.5958/2231-5713.2018.00003.X         Access: Open Access Read More

Author(s): Sarfaraz Md., Arshad Ahmed Khan K., Doddayya H., Reddy S.R. , Udupi R.H.

DOI:         Access: Open Access Read More

Author(s): S. Kumara Swamy, G. Arun, Bethi Srinivas, Agaiah Goud B

DOI: 10.5958/2231-5713.2016.00014.3         Access: Open Access Read More

Author(s): Sunil Kumar, Anil Kumar, Vaibhav Gupta, Kuldeep Malodia, Pankaj Rakha

DOI:         Access: Open Access Read More

Author(s): Godbole Ajeet Madhukar, Patel Bhautik V, Somnache Sandesh Narayan, Prajapati Ashish R, Yadav Pradeep

DOI: 10.5958/2231-5713.2017.00004.6         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags