Author(s):
Y. Sirisha, Dontharaboina Sneha, Ramya Sri S
Email(s):
ysirisha776@gmail.com
DOI:
10.52711/2231-5713.2023.00017
Address:
Y. Sirisha1*, Dontharaboina Sneha1, Ramya Sri S2
1Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad 501301, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad – 500 007, Telangana, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 2,
Year - 2023
ABSTRACT:
In the present work, Microspheres of Sumatriptan Succinate using PLGA, Ethyl cellulose and HPMC K4M as polymers were formulated to deliver Sumatriptan Succinate via oral route. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Sumatriptan Succinate microspheres. In this work an effort was made to formulate microsphere of Sumatriptan Succinate by using different polymers. Prepared formulations are evaluated for bulk density, tapped density, precent mucoadhesion, Percent compressibility, hausners ration, percentage yield, size and interaction study by Differential scanning calorimeter and in vitro drug release. Formulation which passed all the evaluation parameters was considered as best formulation of Sumatriptan Succinate. The present study conclusively that Sumatriptan Succinate microsphere could be prepared successfully and formulation F5 was shows satisfactory result.
Cite this article:
Y. Sirisha, Dontharaboina Sneha, Ramya Sri S. Formulation and Evaluation of Sumatriptan Succinate Microspheres by Using Different Polymers. Asian Journal of Pharmacy and Technology. 2023; 13(2):91-4. doi: 10.52711/2231-5713.2023.00017
Cite(Electronic):
Y. Sirisha, Dontharaboina Sneha, Ramya Sri S. Formulation and Evaluation of Sumatriptan Succinate Microspheres by Using Different Polymers. Asian Journal of Pharmacy and Technology. 2023; 13(2):91-4. doi: 10.52711/2231-5713.2023.00017 Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-2-3
REFERENCES:
1. Saleem MA, Sudhir S. Pange, Shaikh Ahnaf Umair and Vishal Kumar Singh. Development and Evaluation of Mucoadhesive Buccal Tablets of Sumatriptan Succinate using Natural Gums. Research J. Pharm. and Tech. 4(7): July 2011; 1140-1146.
2. A. Elphine Prabahar, R. Kalaichelvi, B. Thangabalan, R. Karthikeyan, Ch. Prabhakar and P. Vijayaraj Kumar. Validated Spectroscopic Method for Estimation of Sumatriptan succinate in Pure and from Tablet Formulation. Research J. Pharm. and Tech.2 (3): July-Sept. 2009,;Page 495-497.
3. Y. Krishna Reddy, Juveria Tasleem. Formulation and Evaluation of Bioadhesive Buccal Drug Delivery of Sumatriptan Succinate Tablets. Asian J. Pharm. Res. 2020; 10(2):105-109. doi: 10.5958/2231-5691.2020.00020.9
4. Buridi Kalyana Ramu and K. Raghubabu. Extractive Visible Spectrophotometric Assay for Sumatriptan Succinate Estimation Based on Ion-Association Complex Formation. Research J. Pharm. and Tech. 4(8): Aug. 2011; 1212-1215.
5. Chetan M Patel, Manan A Patel, Nikhil P Patel, PH Prajapati and CN Patel. Poly Lactic Glycolic Acid (PLGA) As Biodegradable Polymer. Research J. Pharm. and Tech. 3(2): 2010; Page 353-360.
6. B. Meenashi Vanathi, N. Sivagurunathan, K. Narayanan, J. Venkata Rao, N. Udupa. Evaluation of Immuno-Stimulatory Property of PLGA/PBAE Microparticles. Research J. Pharm. and Tech. 7(12): Dec. 2014; 1365-1367.
7. S. Ramya Sri. Formulation and Evaluation of Nizatidine Microspheres. Research J. Science and Tech. 2019; 11(1):14-26. doi: 10.5958/2349-2988.2019.00003.2
8. Rahul Rajge, Saad Khan. Formulation and Characterization of Mucoadhesive Microspheres of Oxazolidines Class Drug for the Treatment of Loosen Enteritis. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(1):1-7. doi: 10.52711/2231-5659.2022.00001
9. Gyanesh Sahu, Harish Sharma, Chanchal Deep Kaur. A Novel Approach of Magnetic Modulated Microspheres. Asian J. Pharm. Res. 3(4): Oct. - Dec.2013; Page 220-224.
10. Batra D., Kakar S., Singh R., Nautiyal U., Magnetic microspheres as a targeted drug delivery system: An overview, Jddr. 2012;1(3):1-17.
11. Dutta P., Sruti J., Patra Ch. N., Rao M. E. B., Floating microspheres: Recent trends in the development of gastrorententive floating drug delivery system, Int. J. Pharm. Sci. Nanotech. 2011;4(1):1296-1306.
12. Mukund J. Y., Kantilal B. R., Sudhakar R. N., Floating microspheres: A review, Braz. J. Pharm. Sci. 2012;48(1):17-30.
13. Kawatra M., Jain U., Ramana J., Recent advances in floating microspheres as gastro-retentive drug delivery system: A review, IJRAPR. 2012;2(3):5-23.
14. Ramteke K.H., Jadhav V.B., Dhole S.N., Microspheres: As carrieres used for novel drug delivery system, IOSRPHR. 2012;2(4):44-48.
15. Dupinder K., Seema S., Gurpreet S., Rana A.C., Biodegradable microspheres: A review, IRJP.2012; 3(12):23-27.
16. Sara Sadique, Ramya Sri S. Preparation and evaluation of fast dissolving oral film of Losartan Potassium. Research Journal of Pharmaceutical Dosage Forms and Technology. 2020., 12(1), 1-4.
17. Ramya Sri Sura., Formulation and Evaluation of Nizatidine Microspheres, Research Journal of Science and Technology., 2019 March., 11 (1), 14-26.
18. Ramya Sri Sura, CVS Subrahmanyam, Shyam Sunder Rachamalla. Design And Evaluation Of Liquisolid Compacts Of nebivolol Hydrochloride (2022). Design and Evaluation of liquisolid compacts of nebivolol hydrochloride. International Journal of Applied Pharmaceutics., 14(2), 293-307.
19. Ramya Sri Sura, Subrahmanyam CVS, Shyam Sunder Rachamalla. Development and evaluation of self micro emulsifying drug delivery system (SMEDDS) for nebivolol hydrochloride (2021). Int. J. Life Sci. Pharma Res. 11(6), P83-97. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.6.P83-97