Author(s):
Srushti S. Gode, Aniket S. Gudur, Neha S. Ghosalkar, Mukul S. Malpure
Email(s):
srushtigode2525@gmail.com
DOI:
10.52711/2231-5713.2025.00011
Address:
Srushti S. Gode1*, Aniket S. Gudur2, Neha S. Ghosalkar2, Mukul S. Malpure2
1Department of Pharmaceutics, St. Wilfred’s Institute of Pharmacy, Panvel - 410206,Maharashtra, India.
2St. Wilfred’s Institute of Pharmacy, Shedung, Panvel Tal - Panvel, Dist. Raigad (410206), Maharashtra, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 1,
Year - 2025
ABSTRACT:
The trend of seeking natural alternatives has triggered the invention of new products known as nutraceuticals which are health-beneficial and have an added value to basic nutrition. Multiple medicinal herbal formulations have brought their synergistic effect to the forefront and enhanced single medicinal therapy's therapeutic potential. This study is concerned with forming and characterizing polyherbal granules as a carrier system for nutraceuticals. The polyherbal granules were prepared using extracts from several plants with antioxidant, anti-inflammatory, and immunomodulatory properties. The granules were designed and prepared to facilitate oral administration, controlled release, and increased bioavailability of the active ingredients. This included identification of the appropriate herbs, extraction of their bioactive components using suitable solvents, and standardization of the preparation of the granules with regard to granulation, drying, and sieving processes. Various physical parameters such as particle size, flow ability, and compressibility were assessed in addition to the kinetics of in vitro release studies of the nutraceuticals incorporated into the granules. The granule formulation was evaluated for its stability under different storage parameters to provide assurance on its effectiveness for a longer period. The preparation of the polyherbal nutraceutical granule has shown good and favourable results within the time period of the study regarding the components used.
Cite this article:
Srushti S. Gode, Aniket S. Gudur, Neha S. Ghosalkar, Mukul S. Malpure. A Broad and Holistic Review of Nutraceutical Granules using Polyherbal. Asian Journal of Pharmacy and Technology. 2025; 15(1):66-2. doi: 10.52711/2231-5713.2025.00011
Cite(Electronic):
Srushti S. Gode, Aniket S. Gudur, Neha S. Ghosalkar, Mukul S. Malpure. A Broad and Holistic Review of Nutraceutical Granules using Polyherbal. Asian Journal of Pharmacy and Technology. 2025; 15(1):66-2. doi: 10.52711/2231-5713.2025.00011 Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-1-11
REFERENCE:
1. Chaudhari, Shilpa P., Priyatama V. Powar, and Mahesh N. Pratapwar. Nutraceuticals: A review. World J. Pharm. Pharm. Sci. 2017; 6(8): 681-739.
2. Vadaga, Anil Kumar, et al. Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms. Intelligent Pharmacy. 2024.
3. Wang, Bo, et al. A critical review on granulation of pharmaceuticals and excipients: Principle, analysis and typical applications. Powder Technology. 2022; 401: 117329.
4. Puri, Vivek, et al. A comprehensive review on nutraceuticals: therapy support and formulation challenges. Nutrients. 2022; 14(21): 4637.
5. AlAli, Mudhi, et al. Nutraceuticals: Transformation of conventional foods into health promoters/disease preventers and safety considerations. Molecules. 2021; 26(9): 2540.
6. Agrawal, Rajesh, and Yadav Naveen. Pharmaceutical processing–A review on wet granulation technology. International Journal of Pharmaceutical Frontier Research. 2011; 1(1): 65-83.
7. Suryawanshi, Amol P., Dattatraya M. Shinkar, and R. B. Saudagar. Granulation techniques. Asian Journal of Research in Pharmaceutical Science. 2015; 5(4): 203-215.
8. Shahidulla, S. M., H. Amtul, and S. A. Azeer. Granulation techniques: an overview. World Journal of Pharmacy and Pharmaceutical Sciences. 2019; 8(5): 525-546.
9. Chen, Ping, et al. A review on key aspects of wet granulation process for continuous pharmaceutical manufacturing of solid dosage oral formulations. Arabian Journal of Chemistry. 2022; 15(2): 103598.
10. Jannat, Esratun, et al. Granulation techniques and its updated modules. The Pharma Innovation. 2016; 5(10): 134.
11. Chew, Yik Ling, et al. A Review on the Development of Granulation Technology in the Past Two Decades. Journal of Pharmaceutical Negative Results. 2022: 93-95.
12. Parikh, Dilip M. Handbook of Pharmaceutical Granulation Technology. Drugs and the Pharmaceutical Sciences. 2005; 81.
13. Hammer K. Steam Granulation Apparatus and Method. Google Patents; 1984.
14. Royce A, Suryawanshi J, Shah U, Vishnupad K. Alternative granulation technique: melt granulation. Drug Development and Industrial Pharmacy. 1996; 22 (9-10): 917-24.
15. Ullah I, Corrao R, Wiley G, Lipper R. Moisture activated dry granulation: A general process. Pharm Technol. 1987; 11: 48-54.
16. Allamneni Y, Allamneni N, Kumar G, Kalekar A, Chary P, Potturi P, et al. Foam granulation technology as an innovation in granulation of pharmaceutical drugs: An overview. International Journal of Pharmaceutical Frontier Research. 2012; 2(2): 68-79.
17. Nsel HC, Popovich NG, Allen LV Jr. Pharmaceutical Dosage Forms and Drug Delivery Systems. B. I. Waverly Pvt. Ltd., New Delhi, 1999; 6: 469-71.