Author(s): Inder Kumar, Ishwar Singh, Kapil Kumar Verma, Sunny Dhiman, Priyankul Palia

Email(s): inder.93kumar@gmail.com

DOI: 10.52711/2231-5713.2023.00019   

Address: Inder Kumar1*, Ishwar Singh2, Kapil Kumar Verma1, Sunny Dhiman2, Priyankul Palia2
1Minerva College of Pharmacy, Indora, Distt. Kangra, HP, India.
2School of Pharmacy, Abhilashi University, Mandi, HP, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2023


ABSTRACT:
Vaginitis is a very common gynaecological problem in women of all age groups. Fluconazole chemically known as 2-(2, 4-diflurophenyl)-1, 3-bis (1H-1, 2, 4-triazole-1-yl)-2-propanol. Is a synthetic triazole derivative antifungal agent that is effective against a wide range of systemic and superficial fungal Infections. The mucoadhesive vaginal tablets were prepared by the direct compression method. FTIR had employed to study drug excipient incompatibility. The mucoadhesive vaginal tablet was evaluated for % swelling index, Muco-adhesive strength, drug content, % drug release, and Invitro Dissolution release. It was observed that more than 85% drug was released within 480 min in direct compression method formulations (FLZ1-FLZ9). Formulation FLZ3 that containing 6% of eudragit revealed maximum drug release profile up to 89.20±0.343% within 480 min, whereas formulation FLZ5 showed 87.20±0.765% drug release. The best formulation was compared with the marketed formulations for in-vitro drug release and showed almost similar drug release. Stability study shows no changes. This study may prove potential vaginal formulation of Fluconazole against bacterial vaginosis.


Cite this article:
Inder Kumar, Ishwar Singh, Kapil Kumar Verma, Sunny Dhiman, Priyankul Palia. Therapeutic Potential of Naturally Modified Mucoadhesive Fluconazole Tablets against Vaginal Infection. Asian Journal of Pharmacy and Technology. 2023; 13(2):101-4. doi: 10.52711/2231-5713.2023.00019

Cite(Electronic):
Inder Kumar, Ishwar Singh, Kapil Kumar Verma, Sunny Dhiman, Priyankul Palia. Therapeutic Potential of Naturally Modified Mucoadhesive Fluconazole Tablets against Vaginal Infection. Asian Journal of Pharmacy and Technology. 2023; 13(2):101-4. doi: 10.52711/2231-5713.2023.00019   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-2-5


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