Author(s): S.D. Mankar, Bhagyashri S. Jadhav, Awantika N. Kale

Email(s): sdmankar655@gmail.com

DOI: 10.52711/2231-5713.2023.00037   

Address: Dr. S.D. Mankar, Bhagyashri S. Jadhav, Awantika N. Kale
Pravara Rural College of Pharmacy, Loni.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2023


ABSTRACT:
While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Despite the fact oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to make easier oral peptide delivery. As well, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonisation and agglutination, free peptides are not systemically stable without modifications. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and stability issues. Methods to increase systemic stability and site-specific delivery are also discussed.


Cite this article:
S.D. Mankar, Bhagyashri S. Jadhav, Awantika N. Kale. Basics and Recent Advances in Peptide and Protein Drug Delivery. Asian Journal of Pharmacy and Technology. 2023; 13(3):207-2. doi: 10.52711/2231-5713.2023.00037

Cite(Electronic):
S.D. Mankar, Bhagyashri S. Jadhav, Awantika N. Kale. Basics and Recent Advances in Peptide and Protein Drug Delivery. Asian Journal of Pharmacy and Technology. 2023; 13(3):207-2. doi: 10.52711/2231-5713.2023.00037   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-3-10


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