ABSTRACT:
Cefuroxime axetil is the oral prodrug formulation of the injectable antibiotic cefuroxime sodium. Cefuroxime is a second generation cephalosporin antibiotic with a broad spectrum activity and a poor absorption profile from gastrointestinal tract. It led to the synthesis of the 1-acetoxyethyl ester of cefuroxime (cefuroxime axetil). Bactericidal activity in vivo is resultant of its binding to essential target proteins, termed the penicillin-binding proteins. Cefuroxime axetil is generally well tolerated. Stevens-Johnson syndrome, toxic epidermal necrolysis, headaches, hypersensitivity reactions and pseudomembranous colitis have also been observed occasionally during cefuroxime axetil treatment. It is not the drug of choice for any infection, particularly those encountered in the field of obstetrics and gynecology. It is safe to use in pregnancy and has a low adverse effect profile.
Cite this article:
Shivani Sharma, Dinesh Kaushik. Cefuroxime Axetil: An oral Prodrug of Cefuroxime Sodium. Asian Journal of Pharmacy and Technology. 2023; 13(4):281-4. doi: 10.52711/2231-5713.2023.00050
Cite(Electronic):
Shivani Sharma, Dinesh Kaushik. Cefuroxime Axetil: An oral Prodrug of Cefuroxime Sodium. Asian Journal of Pharmacy and Technology. 2023; 13(4):281-4. doi: 10.52711/2231-5713.2023.00050 Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-4-8
REFERENCE:
1. Somani J.K. Bhushan, I. Sen, H. Bioavailabe Oral Dosage Form Of Cefuroxime Axetil. US Pat. 6323193 B1, 2001.
2. Woo J.S. Chang H.C. Non-Crystalline Cefuroxime Axetil Solid Dispersant, Process For Preparing Same And Composition For Oral Administration There of. US Pat. 6107290, 2000.
3. Ketan T.S. Anuradha K.G. Jignasa K.S. Drug Solubility: Importance And Enhancement Techniques. ISRN Pharm. V. 2012, N.195727, P.1-10, 2012.
4. Desai K.G.H. Park H.J. Solubility Studies Of Vadecoxib In The Presence Of Carrier, Co-Solvent And Surfactant. Drug Dev. Res. 2004; 62(1): 41-48.
5. Harding MS Williams PO Ayrton J: Pharmacology Of Cefuroxime As The 1-Acetoxyethyl Ester In Volunteers. Antimicrob Agents Chemother. 1984; 25:78-82.
6. Mandell GL. Petri WA: Antimicrobial Agents: Penicillin, Cephalosporins, And Other 3-1actam Antibiotics. In Hardman Jg, Limbird Le (Eds): Goodman And Gilman’s The Pharmacological Basis Of Therapeutics. 9th Edition, New York: Mcgraw-Hill, Pp 1074-1076, 1996.
7. Kees F. Lukassck U. Naber Kg. Grobccker H: Comparative Investigations On The Bioavailability Of Cefuroxime Axetil. Arzneim Forsch. 1991; 41:843-846.
8. Ginsburg CM. Mccracken GH. Petruska M. Olson K: Pharmacokinetics And Bactericidal Activity Of Cefuroxime Axetil. Antimicrob Agents Chemother. 1985; 28:504-507.
9. Finn A. Straughn A. Meyer M. Chubb J: Effect Of Dose And Food On The Bioavailability Of Cefuroxime Axetil. Biopharm Drug Dispos. 1987; 8:519-526.
10. Mackay J. Mackie AE. Palmer JL. Et Al.: Investigations Into The Mechanism For The Improved Oral Systemic Bioavailability Of Cefuroxime From Cefuroxime Axetil When Taken After Food. Br J Clin Pharm. 1992; 33: 226-227.
11. Foord RD: Cefuroxime: Human Pharmacokinetics. Antimicrob Agents Chemother. 1976; 9:741-747.
12. Perry CM. Brogden RN: Cefuroxime Axetilma Review Of Its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Efficacy. Drugs. 1996; 52:125-158.
13. Konishi K. Suzuki H. Hayashi M. Saruta T: Pharmacokinetics of Cefuroxime Axetil In Patients With Normal And Impaired Renal Function. J Antimicrob Chemother. 1993; 31: 413-420.
14. Glaxo Wellcome. Inc.: Cefuroxime Axetil. Package Insert. Research Triangle Park, NC: Glaxo Wellcome, Inc., 1995.
15. Neu HC. Fu KP. Cefuroxime. A [3-1actamase Resistance Cephalosporin With A Broad Spectrum Of Gram Positive And Negative Activity. Antimicrob Agents Chemother. 1978; 13: 657-664.
16. Bradley JS. Kaplan SL. Klugman KP. Leggiadro RJ. Consensus: Management Of Infections In Children Caused By Streptococcus Pneumoniae With Decreased Susceptibility To Penicillin. Pediatr Infect Dis J. 1995; 14:1037- 1041.
17. Sweet RL. Gibbs RS. Antimicrobial Agents. In: Infectious Diseases of Female Genital Tract. 3rd Ed. Baltimore: Williams & Wilkins, Pp 680-683, 1995. 9266665260
18. Sirot J. Chanal C, Petit A, Et Al. Klebsiella Pneumoniae And Other Enterobacteriaceae Producing Novel Plasmidmediated 3-1actamases Markedly Active Against 3rd Generation Cephalosporins: Epidemiological Studies. Rev Infect Dis. 1988; 10:850-859.
19. Briggs GG. Freeman R. Yaffe SJ (Eds): Cefuroxime (Monograph). In: Drugs In Pregnancy And Lactation. 4th Ed. Baltimore: Williams & Wilkins, Pp 147-148, 1994.
20. Centers For Disease Control And Prevention: 1993 Sexually Transmitted Disease Treatment Guidelines. Mmwr 43(Rr-14):57-59, 1993.
21. Gottlieb A. Mills J: Cefuroxime Axetil For Treatment Of Uncomplicated Gonorrhea. Antimicrob Agents Chemother. 1986; 30:333-334.
22. Reichman RC. Nolte FS. Wolinsky SM. Et Al.: Single Dose Cefuroxime Axetil In The Treatment Of Uncomplicated Gonorrhea: A Controlled Trial. Sex Transm Dis. 1985; 12: 184-187.
23. Baddour LM. Gibbs RS. Mertz G. Et Al.: Clinical Comparison Of Single-Oral-Dose Cefuroxime Axetil And Amoxicillin With Probenecid For Uncomplicated Gonococcal Infections In Women. Antimicrob Agents Chemother. 1989; 33: 801-804.
24. Fong IW. Linton W. Simbul M. Hinton Na: Comparative Clinical Efficacy Of Single Oral Doses Of Cefuroxime Axetil And Amoxicillin In Uncomplicated Gonococcal Infections. Antimicrob Agents Chemother. 1986; 30:321-322.
25. Iravani A. Richard GA: Single-Dose Cefuroxime Axetil Versus Multiple-Dose Cefaclor In The Treatment Of Acute Urinary Tract Infections. Antimicrob Agents Chemother. 1989; 33:1212-1216.
26. Naber KG. Koch EMW: Cefuroxime Axetil Versus Ofloxacin For Short-Term Therapy Of Acute Uncomplicated Lower Urinary Tract Infections In Women. Infection. 1993; 21: 34-39.
27. Cooper J. Raeburn A. Brumfitt W. Hamilton-Miller Jmt: Comparative Efficacy And Tolerability Of Cephradine And Cefuroxime Axetil In The Treatment Of Acute Dysuria And/Or Frequency In General Practice. Br J Clin Pract. 1992; 46:24-27.