Author(s):
N. Madhavi, B. Mythili, Ch. Sravani, T. Rama Rao
Email(s):
madhavi@cmrcp.ac.in
DOI:
10.52711/2231-5713.2024.00065
Address:
N. Madhavi1*, B. Mythili1, Ch. Sravani2, T. Rama Rao2
1Department of Pharmaceutics, CMR College of Pharmacy, Affiliated to JNTUH, Medchal, Kandlakoya, Hyderabad - 501401, Telangana, India.
2Professor and Principal, CMR College of Pharmacy, Medchal, Kandlakoya, Hyderabad, Telangana, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 4,
Year - 2024
ABSTRACT:
Adhesion is a phenomenon which is required to promote controlled release of the drug used in pronged therapies. In view of it, desmosomes are the specialized cells which connect cell to cell and thereby it forms tight junctions to promote diffusion of the drug. These desmosomal cadherins are majorly used in drug delivery to the skin, nasal delivery, buccal delivery and ophthalmic delivery where adhesion is required to provide long term therapy. The current review has been informed a mini review on the invention, morphological structure, functions and few applications of desmosomes.
Cite this article:
N. Madhavi, B. Mythili, Ch. Sravani, T. Rama Rao. Desmosomal Cadherins: Specialized Cells for Adhesion Property. Asian Journal of Pharmacy and Technology. 2024; 14(4):412-4. doi: 10.52711/2231-5713.2024.00065
Cite(Electronic):
N. Madhavi, B. Mythili, Ch. Sravani, T. Rama Rao. Desmosomal Cadherins: Specialized Cells for Adhesion Property. Asian Journal of Pharmacy and Technology. 2024; 14(4):412-4. doi: 10.52711/2231-5713.2024.00065 Available on: https://ajptonline.com/AbstractView.aspx?PID=2024-14-4-18
REFERENCES:
1. Pena juarez MC, Guadarrama-Escobar OR, Escobar-Chavez JJ. Transdermal delivery systems of biomolecules. J Pharm Innov. 2021; 17(2): 319-332.
2. Muller L, Hatzfeld M, Keil R. desmosomes as signaling hubs in the regulation of cell behavior. Front Cell Dev Biol. 2021; 9: 745670.
3. Al-Amoudi A, Frangakis AS. Structural studies on desmosomes. Biochem Soc Trans. 2008; 36(Pt 2): 181-7.
4. Delva E, Tucker DK, Kowalczyk AP. The desmosome. Cold Spring Harb Perspect Biol. 2009; 1(2): a002543.
5. Chidgey M. Desmosomes and disease: an update. HistolHistopathol. 2002; 17(4): 1179-92.
6. Morilla MJ, Romero EL. Ultradeformable phospholipid vesicles as a drug delivery system: A review. Research and reports in transdermal drug delivery. 2015; 15(4): 55-69.
7. Huber O. Structure and function of desmosomal proteins and their role in development and disease. CMLS, Cell. Mol. Life Sci. 2003; 60: 1872–1890.
8. Lee DH, Lim S, Kwak SS, Kim J. Advancements in Skin-Mediated Drug Delivery: Mechanisms, Techniques, and Applications. Adv Healthc Mater. 2023; 27: e2302375.
9. Dubald M, Bourgeois S, Andrieu V, Fessi H. Ophthalmic Drug Delivery Systems for Antibiotherapy-A Review. Pharmaceutics. 2018; 10: 10.
10. Jacob S, Nair AB, Boddu SHS, Gorain B, Sreeharsha N, Shah J. An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems. Pharmaceutics. 2021; 13: 1206.
11. Liu YQ, Zou HY, Xie JJ, Fang WK. Paradoxical Roles of Desmosomal Components in Head and Neck Cancer. Biomolecules 2021; 11: 914.
12. Nur Husna SM, Tan HT, Md Shukri N, Mohd Ashari NS, Wong KK. Nasal Epithelial Barrier Integrity and Tight Junctions Disruption in Allergic Rhinitis: Overview and Pathogenic Insights. Front Immunol. 2021; 12: 663626.