Author(s):
Purvi Yadav, Neha Thakur, Anju Mishra, Geetanjali Sahu, Anish Chandy
Email(s):
anishpharma@gmail.com
DOI:
10.52711/2231-5713.2026.00004 
Address:
Purvi Yadav1, Neha Thakur1, Anju Mishra2, Geetanjali Sahu2, Anish Chandy3
1Students, School of Pharmacy, Chouksey Engineering College, Bilaspur (CG) India.
2Assistant Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur (CG), India.
3Associate Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur (CG), India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2026
ABSTRACT:
Objective: The primary goal is to prepare appropriate transdermal patches of the antidiabetic medication glimepiride using varying ratios of polymers (hydroxyl propyl methyl cellulose K-100) in accordance with patient needs (patient compliance) and for superior drug release compared to alternative formulations. These formulations use ethanol and chloroform (1:1) as a solvent system and 0.2 ml of glycerol as a plasticizer. The in-vitro skin penetration experiments were conducted using a Franz diffusion cell and phosphate buffer pH 7.4. Method: A magnetic stirrer was used to prepare the transdermal patches utilizing the solvent casting process. Results: Beer's law was adhered to. between 2 and 12 µg/ml in phosphate buffer at a pH of 7.4. Linear regression equation of pure drug was established as Y=0.058x + 0.1331 and the R 2 value 0.999. Zero order release kinetics implies that the drug release of formulation GTP7 is better than that of the other formulation. Conclusion: Formulation GTP7presented a statistically insignificant change of the percent drug content and permeation profile after 90 days of studies.
Cite this article:
Purvi Yadav, Neha Thakur, Anju Mishra, Geetanjali Sahu, Anish Chandy. Formulation and Evalutaion of Ethosomal Transdermal Patch of Antidiabetic Drug. Asian Journal of Pharmacy and Technology. 2026; 16(1):19-4. doi: 10.52711/2231-5713.2026.00004
Cite(Electronic):
Purvi Yadav, Neha Thakur, Anju Mishra, Geetanjali Sahu, Anish Chandy. Formulation and Evalutaion of Ethosomal Transdermal Patch of Antidiabetic Drug. Asian Journal of Pharmacy and Technology. 2026; 16(1):19-4. doi: 10.52711/2231-5713.2026.00004 Available on: https://ajptonline.com/AbstractView.aspx?PID=2026-16-1-4
REFERENCES:
1. Nagarathna R, Madhava M, Patil SS, Singh A, Perumal K, Ningombam G, Nagendra AH. Cost of management of diabetes mellitus: a pan India study. Annals of Neurosciences. 2020 Jul; 27(3-4): 190-2.
2. Standl E, Khunti K, Hansen TB, Schnell O. The global epidemics of diabetes in the 21st century: Current situation and perspectives. European Journal of Preventive Cardiology. 2019 Dec; 26(2_suppl):7-14.
3. Chauhan L, Vashisht S. Formulation and evaluation of novel herbal antidiabetic transdermal patch. Inno Pharm Pharmacother. 2018; 6(4).
4. Ahad A, Al-Saleh AA, Akhtar N, Al-Mohizea AM, Al-Jenoobi FI. Transdermal delivery of antidiabetic drugs: formulation and delivery strategies. Drug Discovery Today. 2015 Oct 1; 20(10):1217-27.
5. Kinani AA, Taghi HS. Formulation and characterization of orodispersible tablet of glimepiride. Journal of Advanced Pharmaceutical Technology & Research. 2022 Oct 1; 13(4):252-60.
6. Induri M, Raju M B, Prasad Y R, Reddy K P. Development and validation of a spectrophotometric method for quantification and dissolution studies of glimepiride in tablets. Journal of Chemistry. 2012; 9(2):993-8.
7. Shabnam H, Singh DJ, DN P, Anchal P, Sahil K. Formulation and Characterization of Transdermal Patch of Candesartan Celexitil. Journal of Drug Delivery & Therapeutics. 2019 May 2; 9.
8. Singh A, Bali A. Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride. Journal of Analytical Science and Technology. 2016 Nov 28; 7(1):25.
9. Jain S, Gupta S, Sahu N. Formulation and evaluation of TDDS of Indian medicinal plant. Int J Drug Discov Herb Res. 2021; 11:1003-10.
10. Torlak C, Güleli M, Kızılok Ş, Kartop RA, Çalışkan C, KurşunBaysak F. Comparison of permeability of topical Cream drug through polymer synthetic membranes of different structures using Franz Cell diffusion test. Journal of Dispersion Science and Technology. 2024 Aug 9:1-9.