Evaluation of Binding Property of Remusatia vivipara (Roxb) Mucilage in Tablet Formulation

Mayur R. Bhurat; S. D. Barhate

doi:10.5958/2231-5713.2015.00005.7

Asian Journal of Pharmacy and Technology

ISSN

2231-5713 (Online)
2231-5705 (Print)

Submit Article

Evaluation of Binding Property of Remusatia vivipara (Roxb) Mucilage in Tablet Formulation

Author(s): Mayur R. Bhurat, S. D. Barhate

Email(s): bhuratmayur@gmail.com

DOI: 10.5958/2231-5713.2015.00005.7

Address: Mayur R. Bhurat1,2*and Dr. S. D. Barhate1
1Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jammer 2J.J.T. University, Zunzunu, Rajasthan
*Corresponding Author

Published In: Volume - 5, Issue - 1, Year - 2015

View HTML

View PDF

ABSTRACT:
Remusatia vivipara is a common herbaceous belongs to the family of Araceae. Tubers of plant contain mucilage hence attempt to evaluate the tubers for suitability as tablet binder is considered and the present investigation repots the isolation of mucilage of Remusatia vivipara tubers. The DSC and FTIR thermograms of drug and mucilage indicated no chemical interaction. Phytochemical and Physiochemical characteristics of mucilage were studied which confirmed the mucilage nature. The mucilage was evaluated for its granulating and binding properties in compressed tablet using Metformin HCl as model drug. The granules prepared by mucilage with different concentration such as 1%, 3%, 5% and 10% were compared with starch paste, which was used as standard binder. The tablets had good physiochemical properties and the drug release was more than 95% within 24hr. It was observed that decreasing the concentration of mucilage increases hardness and the disintegration time. The tablet prepared using 1% and 3% shows drug release rate in sustained manner and that of standard binder 10% starch paste used for comparison. Remusatia vivipara mucilage could be used as a good binding agent at very low concentrations. This can be used for sustaining the drug release from tablets, since the prepared tablets produced a sticky film of hydration on the surface, which ultimately reduces drug release rate and hence it can be evaluated for its efficacy to sustain the drug release.

Keywords:

Cite this article:
Mayur R. Bhurat, S. D. Barhate. Evaluation of Binding Property of Remusatia vivipara (Roxb) Mucilage in Tablet Formulation. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 1, Pg 23-28. doi: 10.5958/2231-5713.2015.00005.7

Recomonded Articles:

Pharmaceutical Aids – a Review Study

Author(s): Hafsa, Asfa, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00001.0 Access: Open Access Read More

Calculation of predominant drug release mechanism using Peppas-Sahlin model, Part-I (substitution method): A linear regression approach

Author(s): Ravindra Babu Baggi, Naveen Babu Kilaru

DOI: Access: Open Access Read More

Formulation and Evaluation of Mosquito Repellent Activity of Polyherbal Formulations of Extraction of Annona squamosa, Azadirachta indica, Eucalyptus alba, Citrus aurantium and Rosa indica and their phytochemical analysis

Author(s): Praveen Kumar Uppala, J.B. Radhadevi, K. Atchuta Kumar, Bangaruthalli

DOI: 10.5958/2231-5713.2017.00016.2 Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available
DOI: 10.5958/2231–5713