Grishma S. Trivedi, Hasumati A Raj, Vineet C. Jain
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Grishma S. Trivedi*, Hasumati A Raj, Vineet C. Jain
Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, India.
Volume - 5,
Issue - 2,
Year - 2015
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Pravastatin and Valsartan in synthetic mixture using first order derivative zero-crossing method. Pravastatin showed zero crossing point at 262.40 nm while Valsartan showed zero crossing point at 248.20 nm. The dA/d? was measured at 248.20 nm for Pravastatin and 262.80 nm for Valsartan and calibration curves were plotted as dA/d? versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 2-10µg/ml for Pravastatin at 248.20 nm. The linear correlation was obtained (r2>0.9998) in the range of 8-40µg/ml for Valsartan at 262.40 nm. The limit of determination was 0.054µg/ml and 0.024µg/ml for Pravastatin and Valsartan, respectively. The limit of quantification was 0.166µg/ml and 0.074µg/ml for Pravastatin and Valsartan, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Pravastatin and Valsartan in binary mixture.
Cite this article:
Grishma S. Trivedi, Hasumati A Raj, Vineet C. Jain. First Derivative Spectroscopic Method for Simultaneous Estimation of Pravstatin and Valsartan in Synthetic Mixture. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 2, Pg 83-90.