A Principal Component Analysis-Based method for testing Deviation from Ideal Zero Order Release: An Orthodox Approach

Ravindra Babu Baggi

doi:10.5958/2231-5713.2019.00004.7

Asian Journal of Pharmacy and Technology

ISSN

2231-5713 (Online)
2231-5705 (Print)

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A Principal Component Analysis-Based method for testing Deviation from Ideal Zero Order Release: An Orthodox Approach

Author(s): Ravindra Babu Baggi

Email(s): baggi.ravi39@gmail.com

DOI: 10.5958/2231-5713.2019.00004.7

Address: Ravindra Babu Baggi
Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Hyderabad-502 313.
*Corresponding Author

Published In: Volume - 9, Issue - 1, Year - 2019

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ABSTRACT:
The objective of this study was to develop Nicorandil floating tablets by melt granulation technique using almond gum as swellable plus retarding polymer and cetosteryl alcohol as waxy plus retarding polymer. Zero order of drug release is confirmed as drug release from the matrix tablets as it contain higher square of correlation coefficient (R2) than first order kinetics. Further, the drug release data (test) is checked for its deviation from an ideal release profile. The release profiles of the test formulation are slightly deviate the ideal zero order release profile.

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Cite this article:
Ravindra Babu Baggi. A Principal Component Analysis-Based method for testing Deviation from Ideal Zero Order Release: An Orthodox Approach. Asian J. Pharm. Tech. 2019; 9(1):15-22. doi: 10.5958/2231-5713.2019.00004.7

Cite(Electronic):
Ravindra Babu Baggi. A Principal Component Analysis-Based method for testing Deviation from Ideal Zero Order Release: An Orthodox Approach. Asian J. Pharm. Tech. 2019; 9(1):15-22. doi: 10.5958/2231-5713.2019.00004.7 Available on: https://ajptonline.com/AbstractView.aspx?PID=2019-9-1-4

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DOI: 10.5958/2231–5713