Author(s):
Saylee Madkholkar, Vijay Jagtap
Email(s):
tushar.rukari@gmail.com
DOI:
10.52711/2231-5713.2022.00039 
Address:
Tushar Rukari*, Neha Pawar, Swapnali Gawas, Jaydeep Bhoite, Priyanka Jadhav,
Saylee Madkholkar, Vijay Jagtap
Yashwantrao Bhonsale College of Pharmacy, Charathe - Vazarwadi, Tal - Sawantwadi, Dist. Sindhudurg (416510). Maharashtra.
*Corresponding Author
Published In:
Volume - 12,
Issue - 3,
Year - 2022
ABSTRACT:
The COVID-19 pandemic provides an important reminder that one of the most effective ways to stop the spread of germs and stay healthy is also one of the simplest — handwashing. Numerous side effects and increased antimicrobial drugs resistance encouraged us to discover cost effective, secure formulation of herbal plants. In the present study, research work is focused on evaluating the potential of different formulation incorporated with different herbal extracts against antimicrobe. This Polyherbal formulated handwash presents the efficacious study of 3 herbs consisting Andrographis peniculata, Zingiber officinalis and Citrus limon reflecting antimicrobial activity. The aim of present work is to avoid the adverse effects of synthetic formulation. An attempt has been made to formulate this polyherbal handwash by Maceration method of extraction. Followed by formulating then testing. The antimicrobial activity of prepared handwashes was checked against skin pathogens by diffusion wall method. Different combination of ingredients with plant extracts were tested to evaluate the antimicrobial activity by proper zone of inhibition. Thus, these extracts, showed maximum activity with strains of E. coli i.e., gram negative bacteria and Staphylococcus aureus i.e., gram positive bacteria and were found more potent than marketed preparation. Different evaluation parameter i.e., physical testing, pH, foaming, viscosity etc. were carried out on the formulation of different grades. This study “result” divulges that development of Polyherbal Handwash could have great potential for superficial hygiene of hands in turn thus trigger the good health. The usefulness of polyherbal handwash consisting of Andrographis peniculata, Zingiber officinalis, Citrus limoni against most common pathogens in dermatology, suggesting possible role in treating multidrug-resistant mixed infections. This action may be attributed to the synergistic effects for its use. Thus, proved to be most effective product over Healthy Human Hygiene.
Cite this article:
Saylee Madkholkar, Vijay Jagtap. To Study In-Vitro Antimicrobial Activity of Polyherbal Handwash Formulation. Asian Journal of Pharmacy and Technology. 2022; 12(3):237-1. doi: 10.52711/2231-5713.2022.00039
Cite(Electronic):
Saylee Madkholkar, Vijay Jagtap. To Study In-Vitro Antimicrobial Activity of Polyherbal Handwash Formulation. Asian Journal of Pharmacy and Technology. 2022; 12(3):237-1. doi: 10.52711/2231-5713.2022.00039 Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-3-8
REFERENCE:
1. Mousmi D Thakur, Navin R. Sheth, Mihir K Raval, Assessment of In-vitro Anti-inflammatory activity of ginger and diclofenac sodium combination, International Journal of Pharmaceutical Sciences and Drug Research 2020; 12(5): 442-447, ISSN: 0975-248x.
2. Sameer Shafi, Giridhar Raosaheb Shendarkar; Antimicrobial activity of a polyherbal formulation containing Grimum Sanctum, Rubia Cordifolia and glycirrhiza glabra extracts against different microbial species; International Journal of Pharmaceutical Sciences and Drug Research 2021; 13(1): 36-41, ISSN:0975-248x.
3. Mohan Lal; Hand hygiene – effective way to prevent infections; International Journal of Current Research, March 2015, vol. 7, issue:3, pp 13448-13449.
4. Why does low Hand Hygiene Compliance Still Plague…? www.beckershospitalreview.com/.../why_does_low_hand_hygiene_compliance accessed 10 Aug 2020.
5. Hand Washing Reason To Save Many – SlideShare www.slideshre.nrt/doctorrao/hand_washing_reason_to_save_many accessed 10 Aug 2020.
6. Sandeep D.S et al. Formulation of Antimicrobial Polyherbal Hand wash; Research J. Pharm. and Tech. 9(7): July 2016 ISSN 0974- 3618 (Print), 0974 -360X (Online).
7. V. Rajalakshmi, Dr. L. Cathrine; Phytochemical screening and antimicrobial activity of ethanolic extract of Andrographis paniculata; Journal of Pharmacognosy and Phytochemistry 2016; 5(2) :175-177.
8. Joseph Joselin and Solomon Jeev, Andrographis paniculata: A Review of its Traditional Uses; Phytochemistry and Pharmacology: Medicinal and Aromatic Plants. Volume 3, Issue 4, 2004: 1-15. ISSN : 2167-0412.
9. Niranjan A, Tiwari SK, Lehri A., Biological activities of Kalmegh (Andrographis paniculata) and its active principles a review; International journal of Natural Products and Resources, 2010; (2): 125-135.
10. V. Santo Gracee, Antimicrobial activity of ethanolic extract of Zingiber officinale -an In vitro study; Journal of Pharmaceutical Science and Research, al J.Pharma.Sci and Res. vol 9 (9), 2017, 1417 - 1419, ISSN: 0975 – 1459.
11. Tan Bkh and Vanitha J (2004), Immunomodulatory and antibacterial effects of some Traditional Chinese Medicinal Herbs: A Review; Curr. Med. Chem., 11(11); 1423-1430.
12. Habib S. H. M., Makpol S. et al, Ginger extract (zingiber officinale) has anticancer and anti-inflammatory effects on ethionine induced hepatoma rats- clinics 63; 807-813.
13. Burt, S. A. 2004, Essential oils: Their antibacterial properties and potential applications in foods: A Review. Inter. J. Food Microbial. 94: 223-253.
14. Shahnah, S. M., S. Ali et al, New sesquiterpene derivative from fruit peel of Citrous limon (Linn) Burn. F. Sci. Pharm., 75: 165-170.
15. Maruti J. Dhanavale et al. Dept. of Microbiology, Shivaji University Kolhapur-416004 Maharashtra, India. Study antimicrobial activity of lemon (Citrus Lemon) peel extract, British Journal of Pharmacology and Toxicology 2(3): 119-122, 2011. ISSN - 2044 – 2407.