Author(s): Manasi Mehetar, Suvir Darekar

Email(s): manasimehetar98@gmail.com

DOI: 10.52711/2231-5713.2023.00027   

Address: Manasi Mehetar*, Suvir Darekar
Department of Pharmaceutics, Indira College of Pharmacy, Niramay, New, Old Mumbai Rd, Tathawade, Pune, Maharashtra 411033, (M.S.) India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2023


ABSTRACT:
Microneedles (MNs) are one of the efficient and a unique technique of a drug delivery. MNs are a transdermal drug delivery system which is painless, less invasive with a high drug bioavailability. Over the several years, various research around the world have reported superb featuresof MNs in distinct areas of health care. In relation to the wise use of MNs, in this review we deal in depth with the types of MNs, present fabrication methods, and applications of MNs in drug delivery. Recent advancements in 3D printing and digital technology are contributing to the betterment of MNs fabrication technology. Transdermal drug delivery has the advantage of bypassing the first-pass effect as well as allows the sustained release of the drug. MNs are a transdermal drug delivery system that is painless, less invasive, and easy to self-administer, with a high drug bioavailability. The present review coversseveral fabricating materials and fabrication methods which are used for MN preparation. This review also covers the distinctive applications of MNs, which holds great potential in health care industry.


Cite this article:
Manasi Mehetar, Suvir Darekar. Microneedles: A Pharmaceutical Review. Asian Journal of Pharmacy and Technology. 2023; 13(2):146-4. doi: 10.52711/2231-5713.2023.00027

Cite(Electronic):
Manasi Mehetar, Suvir Darekar. Microneedles: A Pharmaceutical Review. Asian Journal of Pharmacy and Technology. 2023; 13(2):146-4. doi: 10.52711/2231-5713.2023.00027   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-2-13


REFERENCES:
1.    Waghule T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, Dua K. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & Pharmacotherapy. 2019 Jan 1; 109:1249-58.
2.    Thakur Singh RR, Tekko I, McAvoy K, McMillan H, Jones D, Donnelly RF. Minimally invasive microneedles for ocular drug delivery. Expert Opinion on Drug Delivery. 2017 Apr 3; 14(4):525-37.
3.    Coulman S, Allender C, Birchall J. Microneedles and other physical methods for overcoming the stratum corneum barrier for cutaneous gene therapy. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2006; 23(3).
4.    He X, Sun J, Zhuang J, Xu H, Liu Y, Wu D. Microneedle system for transdermal drug and vaccine delivery: devices, safety, and prospects. Dose-Response. 2019 Oct 14; 17(4):1559325819878585.
5.    Jung JH, Jin SG. Microneedle for transdermal drug delivery: current trends and fabrication. Journal of Pharmaceutical Investigation. 2021 Sep; 51(5):503-17.
6.    Tucak A, Sirbubalo M, Hindija L, Rahić O, Hadžiabdić J, Muhamedagić K, Čekić A, Vranić E. Microneedles: Characteristics, materials, production methods and commercial development. Micromachines. 2020 Nov; 11(11):961.
7.    Yang J, Liu X, Fu Y, Song Y. Recent advances of microneedles for biomedical applications: drug delivery and beyond. Acta Pharmaceutica Sinica B. 2019 May 1; 9(3):469-83.
8.    Avcil M, Çelik A. Microneedles in Drug Delivery: Progress and Challenges. Micromachines. 2021 Nov; 12(11):1321.
9.    Damiri F, Kommineni N, Ebhodaghe SO, Bulusu R, Jyothi VG, Sayed AA, Awaji AA, Germoush MO, Al-Malky HS, Nasrullah MZ, Rahman MH. Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges. Pharmaceuticals. 2022 Feb 3; 15(2):190.
10.    Ventrelli L, MarsilioStrambini L, Barillaro G. Microneedles for transdermal biosensing: current picture and future direction. Advanced Healthcare Materials. 2015 Dec; 4(17):2606-40.
11.    Guillot AJ, Cordeiro AS, Donnelly RF, Montesinos MC, Garrigues TM, Melero A. Microneedle-based delivery: an overview of current applications and trends. Pharmaceutics. 2020 Jun; 12(6):569.  
12.    Dugam S, Tade R, Dhole R, Nangare S. Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives. Future Journal of Pharmaceutical Sciences. 2021 Dec; 7(1):1-26.
13.    Hong X, Wei L, Wu F, Wu Z, Chen L, Liu Z, Yuan W. Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine. Drug Design, Development and Therapy. 2013; 7:945.
14.    Menon I, Bagwe P, Gomes KB, Bajaj L, Gala R, Uddin MN, D’souza MJ, Zughaier SM. Microneedles: a new generation vaccine delivery system. Micromachines. 2021 Apr; 12(4):435.
15.    Kirkby M, Hutton AR, Donnelly RF. Microneedle mediated transdermal delivery of protein, peptide and antibody based therapeutics: current status and future considerations. Pharmaceutical Research. 2020 Jun; 37(6):1-8.
16.    Alimardani V, Abolmaali SS, Tamaddon AM, Ashfaq M. Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy. Drug Delivery and Translational Research. 2021 Jun; 11(3):788-816.
17.    Duarah S, Sharma M, Wen J. Recent advances in microneedle-based drug delivery: Special emphasis on its use in paediatric population. European Journal of Pharmaceutics and Biopharmaceutics. 2019 Mar 1; 136:48-69.
18.    Donnelly RF, Morrow DI, Singh TR, Migalska K, McCarron PA, O'Mahony C, Woolfson AD. Processing difficulties and instability of carbohydrate microneedle arrays. Drug Development and Industrial Pharmacy. 2009 Oct 1; 35(10):1242-54.
19.    Sharma S, Hatware K, Bhadane P, Sindhikar S, Mishra DK. Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies. Materials Science and Engineering: C. 2019 Oct 1; 103:109717.
20.    Trommer H, Neubert RH. Overcoming the stratum corneum: the modulation of skin penetration. Skin Pharmacology and Physiology. 2006; 19(2):106-21.
21.    Rad ZF, Prewett PD, Davies GJ. An overview of microneedle applications, materials, and fabrication methods. Beilstein Journal of Nanotechnology. 2021 Sep 13; 12(1):1034-46.
22.    Hoang MT, Ita KB, Bair DA. Solid microneedles for transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride. Pharmaceutics. 2015 Dec; 7(4):379-96.
23.    Baek SH, Shin JH, Kim YC. Drug-coated microneedles for rapid and painless local anesthesia. Biomedical Microdevices. 2017 Mar; 19(1):1-1.
24.     Sullivan SP, Koutsonanos DG, del Pilar Martin M, Lee JW, Zarnitsyn V, Choi SO, Murthy N, Compans RW, Skountzou I, Prausnitz MR. Dissolving polymer microneedle patches for influenza vaccination. Nature Medicine. 2010 Aug; 16(8):915-20.
25.    Daugimont L, Baron N, Vandermeulen G, Pavselj N, Miklavcic D, Jullien MC, Cabodevila G, Mir LM, Préat V. Hollow microneedle arrays for intradermal drug delivery and DNA electroporation. The Journal of Membrane Biology. 2010 Jul; 236(1):117-25.
26.    Lee K, Jung H. Drawing lithography for microneedles: a review of fundamentals and biomedical applications. Biomaterials. 2012 Oct 1; 33(30):7309-26.
27.    Cordeiro AS, Tekko IA, Jomaa MH, Vora L, McAlister E, Volpe-Zanutto F, Nethery M, Baine PT, Mitchell N, McNeill DW, Donnelly RF. Two-photon polymerisation 3D printing of microneedle array templates with versatile designs: application in the development of polymeric drug delivery systems. Pharmaceutical Research. 2020 Sep; 37(9):1-5.  
28.    Ruggiero F, Vecchione R, Bhowmick S, Coppola G, Coppola S, Esposito E, Lettera V, Ferraro P, Netti PA. Electro-drawn polymer microneedle arrays with controlled shape and dimension. Sensors and Actuators B: Chemical. 2018 Feb 1; 255:1553-60.
29.    Tarbox TN, Watts AB, Cui Z, Williams RO. An update on coating/manufacturing techniques of microneedles. Drug Delivery and Translational Research. 2018 Dec; 8(6):1828-43.
30.    Choi CK, Lee KJ, Youn YN, Jang EH, Kim W, Min BK, Ryu W. Spatially discrete thermal drawing of biodegradable microneedles for vascular drug delivery. European Journal of Pharmaceutics and Biopharmaceutics. 2013 Feb 1; 83(2):224-33.
31.    Chen Z, Ren L, Li J, Yao L, Chen Y, Liu B, Jiang L. Rapid fabrication of microneedles using magnetorheological drawing lithography. Actabiomaterialia. 2018 Jan 1; 65:283-91.
32.    Ren L, Jiang Q, Chen Z, Chen K, Xu S, Gao J, Jiang L. Flexible microneedle array electrode using magnetorheological drawing lithography for bio-signal monitoring. Sensors and Actuators A: Physical. 2017 Dec 1; 268:38-45.
33.    Kim JD, Kim M, Yang H, Lee K, Jung H. Droplet-born air blowing: Novel dissolving microneedle fabrication. Journal of Controlled Release. 2013 Sep 28; 170(3):430-6.
34.    Ita K. Dissolving microneedles for transdermal drug delivery: Advances and challenges. Biomedicine & Pharmacotherapy. 2017 Sep 1; 93:1116-27.
35.    Kim JD, Bae JH, Kim HK, Jeong DH. Droplet-born Air Blowing (DAB) technology for the industrialization of dissolving microneedle. InProceedings of the World Congress on Recent Advances in Nanotechnology, Prague, Czech Republic 2016 Apr (pp. 1-2).
36.    Lutton RE, Moore J, Larrañeta E, Ligett S, Woolfson AD, Donnelly RF. Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation. Drug Delivery and Translational Research. 2015 Aug; 5(4):313-31.
37.    McCrudden MT, Alkilani AZ, McCrudden CM, McAlister E, McCarthy HO, Woolfson AD, Donnelly RF. Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs. Journal of Controlled Release. 2014 Apr 28; 180:71-80.
38.    Davis SP, Landis BJ, Adams ZH, Allen MG, Prausnitz MR. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. Journal of Biomechanics. 2004 Aug 1; 37(8):1155-63.
39.    Park YL, Elayaperumal S, Daniel B, Ryu SC, Shin M, Savall J, Black RJ, Moslehi B, Cutkosky MR. Real-time estimation of 3-D needle shape and deflection for MRI-guided interventions. IEEE/ASME Transactions On Mechatronics. 2010 Oct 21; 15(6):906-15.
40.    Kong XQ, Zhou P, Wu CW. Numerical simulation of microneedles' insertion into skin. Computer Methods in Biomechanics and Biomedical Engineering. 2011 Sep 1; 14(9):827-35.
41.    Badran MM, Kuntsche J, Fahr A. Skin penetration enhancement by a microneedle device (Dermaroller®) in vitro: Dependency on needle size and applied formulation. European Journal of Pharmaceutical Sciences. 2009 Mar 2; 36(4-5):511-23.
42.    Paleco R, Vučen SR, Crean AM, Moore A, Scalia S. Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles. International Journal of Pharmaceutics. 2014 Sep 10; 472(1-2):206-13.
43.    Teo MA, Shearwood C, Ng KC, Lu J, Moochhala S. In vitro and in vivo characterization of MEMS microneedles. Biomedical Microdevices. 2005 Mar; 7(1):47-52.
44.    Economidou SN, Douroumis D. 3D printing as a transformative tool for microneedle systems: Recent advances, manufacturing considerations and market potential. Advanced Drug Delivery Reviews. 2021 Jun 1; 173:60-9.
45.    Kim YC, Edelhauser HF, Prausnitz MR. Targeted delivery of antiglaucoma drugs to the supraciliary space using microneedles. Investigative Ophthalmology & Visual Science. 2014 Nov 1; 55(11):7387-97.
46.    Panda A, Matadh VA, Suresh S, Shivakumar HN, Murthy SN. Non-dermal applications of microneedle drug delivery systems. Drug Delivery and Translational Research. 2021 Feb 24:1-2.
47.    Xie L, Zeng H, Sun J, Qian W. Engineering microneedles for therapy and diagnosis: a survey. Micromachines. 2020 Mar; 11(3):271.
48.    Babity S, Roohnikan M, Brambilla D. Advances in the design of transdermal microneedles for diagnostic and monitoring applications. Small. 2018 Dec; 14(49):1803186.
49.    Singh V, Kesharwani P. Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer. Journal of Controlled Release. 2021 Oct 10; 338:394-409.
50.    Alimardani V, Abolmaali SS, Tamaddon AM, Ashfaq M. Recent advances on microneedle arrays-mediated technology in cancer diagnosis and therapy. Drug Delivery and Translational Research. 2021 Jun; 11(3):788-816.
51.    Shin CI, Jeong SD, Rejinold NS, Kim YC. Microneedles for vaccine delivery: challenges and future perspectives. Therapeutic Delivery. 2017 Jun; 8(6):447-60.
52.    Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Advanced Drug Delivery Reviews. 2012 Nov 1; 64(14):1547-68.
53.    Schoellhammer CM, Langer R, Traverso G. Of microneedles and ultrasound: Physical modes of gastrointestinal macromolecule delivery. Tissue Barriers. 2016 Apr 2; 4(2):e1150235.
54.    Traverso G, Schoellhammer CM, Schroeder A, Maa R, Lauwers GY, Polat BE, Anderson DG, Blankschtein D, Langer R. Microneedles for drug delivery via the gastrointestinal tract. Journal of Pharmaceutical Sciences. 2015 Feb; 104(2):362-7.
55.    Kim M, Yang H, Kim H, Jung H, Jung H. Novel cosmetic patches for wrinkle improvement: Retinylretinoate‐and ascorbic acid‐loaded dissolving microneedles. International Journal of Cosmetic Science. 2014 Jun; 36(3):207-12.
56.    Bhatnagar S, Dave K, Venuganti VV. Microneedles in the clinic. Journal of Controlled Release. 2017 Aug 28; 260:164-82.
57.    Park Y, Park J, Chu GS, Kim KS, Sung JH, Kim B. Transdermal delivery of cosmetic ingredients using dissolving polymer microneedle arrays. Biotechnology and Bioprocess Engineering. 2015 Jun; 20(3):543-9.
58.    Park Y, Kim KS, Chung M, Sung JH, Kim B. Fabrication and characterization of dissolving microneedle arrays for improving skin permeability of cosmetic ingredients. Journal of Industrial and Engineering Chemistry. 2016 Jul 25; 39:121-6.
59.    Sneha Mali, Sanket Rathod, Niraj Kale, NamdeoShinde. Overview of Nutraceuticals. Asian Journal of Pharmaceutical Research. 2022; 12(1):61-0.
60.    Popat S. Kumbhar, Tejaswini P. Jadhav, Swapnil S. Chopade, Tejas T. Gavade, Rushikesh C. Sorate, Tejaswini U. Shinde, Pratik P. Maske, John I. Disouza, Arehalli S. Manjappa. Microneedles: An Advanced approach for Transdermal Delivery of Biologics. Asian J. Pharm. Res. 2021; 11(1):46-54.
61.    S. More, T. Ghadge, S. Dhole. Microneedle: an Advanced Technique in Transdermal Drug Delivery System. Asian J. Res. Pharm. Sci. 2013; Vol. 3: Issue 3, Pg 141-148.
62.    Sanket Rathod, Sneha Mali, NamdeoShinde, NageshAloorkar. Cosmeceuticals and Beauty Care Products: Current trends with future prospects. Research J. Topical and Cosmetic Sci. 2020; 11(1):45-51.
63.    Ch. Nagadev, M. DurgaSrinivasa Rao, P. Venkatesh, D. Hepcykalarani, R. Prema. A Review on Transdermal Drug Delivery Systems. Asian J. Res. Pharm. Sci. 2020; 10(2):109-114.
64.    Sanket Rathod, KetakiShinde, NamdeoShinde, NageshAloorkar. Cosmeceuticals and Nanotechnology in Beauty Care Products. Research Journal of Topical and Cosmetic Sciences. 2021; 12(2):93-1.
65.    Rajashri R. Kulkarni, Dipti G. Phadtare. The Microneedle Patches: An Innovative Approach. Asian J. Pharm. Tech. 2015; Vol. 5(4): 195-200.

Recomonded Articles:

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Kanchan R. Pagar, Sarika V. Khandbahale

DOI: 10.5958/2231-5713.2019.00023.0         Access: Open Access Read More

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): Sanjay Kshirsagar, Manisha Choudhari, Reshmi Sathyan, Shruti Dhore

DOI: 10.5958/2231-5713.2019.00024.2         Access: Open Access Read More

Author(s): Girishchandra R., Mandake, Shital S. Shinde, Vishal Y. Belaskar, Asha M. Jagtap, Ganesh B. Vambhurkar, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00033.8         Access: Open Access Read More

Author(s): Vishwas R. Potphode, Amol S. Deshmukh, Vijay R. Mahajan

DOI:         Access: Open Access Read More

Author(s): Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar

DOI: 10.5958/2231-5713.2020.00046.X         Access: Open Access Read More

Author(s): Vanitha Kondi, Ramesh Alluri

DOI:         Access: Open Access Read More

Author(s): Jangam Payal R, Thombre Nilima A, Gaikwad Pallavi N

DOI: 10.5958/2231-5713.2017.00027.7         Access: Open Access Read More

Author(s): K. V. M. Krishna, V. Jagannadha Patro

DOI: 10.52711/2231-5713.2023.00005         Access: Closed Access Read More

Author(s): Neha Srivastava, Seema Thakur, Anchal Bajaj, Nikita Sahi

DOI:         Access: Open Access Read More

Author(s): S. Kumara Swamy, G. Arun, Bethi Srinivas, Agaiah Goud B

DOI: 10.5958/2231-5713.2016.00014.3         Access: Open Access Read More

Author(s): AVS Madhu Latha, T Naga Ravikiran, J N Suresh Kumar

DOI: 10.5958/2231-5713.2019.00001.1         Access: Open Access Read More

Author(s): Nitin A. Gaikwad, Abhishek S. Pujari , Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane

DOI: 10.5958/2231-5713.2019.00017.5         Access: Open Access Read More

Author(s): Dhiraj A. Khairnar, Avinash B. Darekar, Ravindra B. Saudagar

DOI: 10.5958/2231-5713.2016.00018.0         Access: Open Access Read More

Author(s): R.B. Saudagar, S. Samuel

DOI: 10.5958/2231-5713.2016.00019.2         Access: Open Access Read More

Author(s): Mayuri M. Shitole, Shailesh S. Dugam, Neha D. Desai, Rahul S. Tade, Sopan N. Nangare

DOI: 10.5958/2231-5713.2020.00032.X         Access: Open Access Read More

Author(s): Tushar N. Sonawane, Pradip D. Dhangar, Sagar D. Patil, Azam Z. Shaikh

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags