Author(s): P. M. Kale

Email(s): Email ID Not Available

DOI: 10.52711/2231-5713.2024.00029   

Address: P. M. Kale*
Sr. Lecturer, Shree Ambabai Talim Sanstha’s Diploma in Pharmacy College, Miraj.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2024


ABSTRACT:
In the present study, inclusion complexes of Efavirenz were developed with HPß-cyclodextrin (HPß-CD). The complexes were prepared by kneading method. Inclusion complexes of with HPß-CD in aqueous solution were evaluated for phase solubility. The phase solubility diagram with the complexing agent was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex. The apparent complexation constant obtained was 820M1¯. The drug was compatible with the polymers used. It was confirmed by fourier-transform infrared spectra. The study indicated the presence of intermolecular hydrogen bonds between and complexing agent, resulting in the formation of amorphous form. Dissolution profiles were markedly increased in inclusion complexes, compared with the drug alone and physical mixture. Moreover, the inclusion complex prepared by kneading method was shown better aqueous solubility and dissolution profile than complex prepared by physical mixture.


Cite this article:
P. M. Kale. Solubility Enhancement of Efavirenz by Microwave Technology. Asian Journal of Pharmacy and Technology. 2024; 14(2):163-2. doi: 10.52711/2231-5713.2024.00029

Cite(Electronic):
P. M. Kale. Solubility Enhancement of Efavirenz by Microwave Technology. Asian Journal of Pharmacy and Technology. 2024; 14(2):163-2. doi: 10.52711/2231-5713.2024.00029   Available on: https://ajptonline.com/AbstractView.aspx?PID=2024-14-2-13


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