Author(s):
Rani Mishra, Kamlesh Dashora, Praveen Khirwadkar, Tanu Bhargava
Email(s):
hanumanaleauf002@gmail.com
DOI:
10.52711/2231-5713.2025.00023 
Address:
Rani Mishra, Kamlesh Dashora, Praveen Khirwadkar, Tanu Bhargava
Institute of Pharmacy, Vikram University, Ujjain (M.P.) Pin 456010.
*Corresponding Author
Published In:
Volume - 15,
Issue - 2,
Year - 2025
ABSTRACT:
The stratum Corneum which is believed to work as a barrier for drug delivery. The transdermal route is one of the most popular ways to administer medication because of its easy permeability. The novel- vesicular carrier among them which has the ability to penetrate the stratum corneum. Vesicular carrier include liposomes, Niosomes, transferosomes, ethosomes and Transethosomes. Transethosomes are more effective as compared to ethosomes and transferosomes because it contain more amount of ethanol with edge activator which increase the stratum corneum permeation. In this article reviewed detail about advantage and disadvantage, methods of preparation and evaluation of Transethosomes and various works which are done in Transethosomes in the treatment of various kinds of diseases.
Cite this article:
Rani Mishra, Kamlesh Dashora, Praveen Khirwadkar, Tanu Bhargava. Transethosomes: Utilization in Novel Drug Delivery System. Asian Journal of Pharmacy and Technology. 2025; 15(2):141-0. doi: 10.52711/2231-5713.2025.00023
Cite(Electronic):
Rani Mishra, Kamlesh Dashora, Praveen Khirwadkar, Tanu Bhargava. Transethosomes: Utilization in Novel Drug Delivery System. Asian Journal of Pharmacy and Technology. 2025; 15(2):141-0. doi: 10.52711/2231-5713.2025.00023 Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-2-7
REFERENCES:
1. Mishra KK, Kaur CD, Verma S, Sahu AK, Dash DK, Kashyap P, Mishra SP. Transethosomes and nanoethosomes: Recent approach on transdermal drug delivery system. Nanomedicine. 2019; 2:33-54.
2. Chen M, Liu X, Fahr A. Skin penetration and deposition of carboxy fluorescein and temoporfin from different lipid vesicular systems: in vitro study with finite and infinite dosage application. Int J Pharm. 2011; 408(1–2):223–234.
3. Ahad, A.; Al-Saleh, A.A.; Al-Mohizea, A.M.; Al-Jenoobi, F.I.; Raish, M.; Yassin, A.E.B.; Alam, M.A. Formulation and characterization of novel soft Nano vesicles for enhanced transdermal delivery of eprosartan mesylate. Saudi Pharm. J. 2017, 25, 1040–1046. [CrossRef] [PubMed]
4. Salem HF, Kharshoum RM, Abou-Taleb HA, AbouTaleb HA, AbouElhassan KM. Progesterone loaded nanosized transethosomes for vaginal permeation enhancement: formulation, statistical optimization, and clinical evaluation in anovulatory polycystic ovary syndrome. Journal of Liposome Research. 2019 Jun; 29(2):183-194.
5. Jessy Shaji RB. Transethosomes: a New Prospect for Enhanced Transdermal Delivery. IJPSR. 2018;9(7):2681-2685.
6. Bhana R, Verma A and Jain S: Development and characterization of ethosomes bearing losartan potassium for transdermal drug delivery. Int J Pharm Pharm Sci. 2013; 5(1): 35-40.
7. Kirjavainen M, Urtti A, Jääskeläinen I, Suhonen TM, Paronen P, et al .1996. Interaction of liposomes with human skin in vitro the influence of lipid composition and structure. Biochem composition Acta 1304(3):179-89.
8. EI Maghraby G m, Williams A C, Barry B W .2001. Skin delivery of 5- fluorouracil from ultradeformable and standard liposomes in vitro. J Pharm Pharmacol 53(8): 1069-1077. Doi.org/10.1211/0022357011776450.
9. Cevc G. 1996. Transferosomes, liposomes and other lipid suspension on the skin: permeation enhancement, vesicles penetration and Transdermal drug delivery: crit rev ther drug carrier syst 13(3-4):257-388. Doi:10.4103/2231-4040.85524.
10. Honeywell- Nguyen P L, Bouwstra J A .2003. The in vitro transport of pergolide from surfactants based elastic vesicles through human skin: a suggest mechanism of action. J control Release 86(1):145-156.
11. Trotta M, Peira E, Carlotti M E, Gallorate M. 2004. Deformable liposomes for dermal administration of methotrexate. Int J Pharm. 270(1-2):119-125.
12. Nayak D, Thathapudi NC, Ashe S, Nayak B. Bioengineered ethosomes encapsulating AgNPs and tasar silk sericin proteins for non-melanoma skin carcinoma (NMSC) as alternative therapeutics. Int J Pharm. 2021; 596:120265.
13. Kumar L, Verma S, Singh K, Prasad DN, Jain AK. Ethanol Based Vesicular Carriers in Transdermal Drug Delivery: Nanoethosomes and Transethosomes in Focus. Nano World J. 2016;2(3):41-51.
14. Jondhalekar TM, Aher SS, Saudagar RB. Transethosome: Novel vesicular carrier for enhanced transdermal drug delivery system. Res J Pharm Technol. 2017;10(6):1816-9.
15. Ibrahim NA, Darwis Y, et al., Ethosomal Nano carriers: the impact of constituents and formulation techniques on ethosomal properties, in-vivo studies, and clinical trials. Int. J. Nanomedicine. 2016; 11: 2279-2304.
16. Dianzani C, Zara GP, Maina G, Pettazzoni P, Pizzimenti S, Rossi F, Gigliotti CL, Ciamporcero ES, Daga M and Barrera G: Drug delivery nanoparticles in skin cancers. 2014.
17. Cevc G, Vierl U, Mazgareanu S. Functional characterisation of novel analgesic product based on self-regulation drug carriers. Int J pharm, 2008; 360(1-2): 18-28.
18. Bajaj KJ, Parab BS, Shidhaye SS. Nano-Transethosomes: A Novel Tool for Drug Delivery through Skin. Indian J Pharm Edu Res. 2021; 55(1): S1-S10.
19. I, Yu C, Chen R, et al. We are Intech Open, the world’ s leading publisher of Open Access books Built by scientists, for scientists TOP 1 %. Intech. 2012; I (tourism):13
20. Goindi S, Dhatt B, Kaur A. Ethosomes-based topical delivery system of antihistaminic drug for treatment of skin allergies. J Microencapsul. 2014;31(7):716-724.
21. Sravani A, Shyamala SJ. An updated review on Transethosomes. World J Pharm Res. 2019;8(13):629-37.
22. Saieshwari K, Gopinath E, Ganesh N.S, Vineeth Chandy. Transethosomes: A novel drug delivery through skin. IJARIIE. 2022;8(2):1736-1746.
23. Utreja P, Kumar L, Formulation and characterization of Transethosomes for enhanced transdermal delivery of Propranolol hydrochloride. Micro and Nano system, 2020; 12(1), (38-47).
24. Yusuf N A, Chaeruniseaa A Y, Abdassah M, Mauludin R, Glibenclamide Transethosomes patch for transdermal delivery: formulation and evaluations. Int J App Pharm. 2023; 15(5), 303-309.
25. Bin Jardan, Y.A., Ahad A, Raish M, Al-Jenoobi F I, Preparation and characterization of Transethosomes formulation for the enhanced delivery of sinapic acid. Pharmaceutics. 2023,15,2391.
26. Aprianti I, Iskandarsyah, Setiawan H, Diflunisal Transethosomes for transdermal delivery: formulation and characterization. Int J App Pharm. 2023; 15(3), 61-66.
27. Gadad A P, Patil A S, Singh Y, Dandagi P M, Development and Evaluation of flurbiprofen loaded Transethosomes to improve transdermal delivery. Indian J of Pharmaceutical Education and Research.2020;54(4);954-62.
28. Verma A, Mishra M, Formulation and characterization of Transethosomal- Loaded Nanoparticles of Irbesartan. Int J for Pharm Res Scholars. 2021;10(1),28-35.
29. Hassan A S, Hofni A, Abourehab M AS, Abdel-Rahman I AM, Ginger Extract- loaded Transethosomes for effective Transdermal permeation and Anti- Inflammation in Rat Model. Int J of Nanomedicine. 2023; 18.1259-1280.
30. Shaji J, Bajaj R, Formulation development of 5- fluorouracil Transethosomes for skin cancer therapy. Ijppr.Human, 2017:11(1); 453-464.
31. Rahangdale M, Pandey P, Development and characterization of Apremilast Transethosomal gel for Transdermal delivery. Int J of Pharm Sci and Nanotechnology, 2021:14(3); 5508-5518. DOI: 10.37285/ijpsn.2021.14.3.8.
32. Gupta V, Joshi N K, Formulation, Development and Evaluation of ketoprofen loaded Transethosomal gel. Journal of drug delivery and Therapeutics.2022; 12(1):86-90.
33. Shaji J, Garude S, Transethosomes and Ethosomes for enhanced Transdermal delivery of Ketorolac Tromethamine: A Comparative assessment. Int J curr Pharm Res. 2014;6(4):88-93.
34. Abdellatif A.A.H.; Aldosari B N; AI-Subaiyel A; Alhaddad A; Samman W A; Elerky N E; Elnaggar M G; Barakat H; Tawfeek H M. Transethosomal gel for the topical delivery of Celecoxib formulation and estimation of skin cancer progression. Pharmaceutics. 2023; 15(22).
35. Chen Z X, Li B, Liu T, Wang X, Zhu Y, Wang L, Wang X.H., Niu X, Xiao Y, Sun O. Evaluation of Paeonol – loaded Transethosomes as transdermal delivery carriers. European J of Pharm Sci.2017; 99:240-245.
36. Adib S N, Gupta I, Aqil M, Mujeeb M. Baicalin loaded Transethosomes for rheumatoid arthritis; Development, Characterization, Pharmacokinetic and Pharmacodynamics Evaluation. J of Drug Delivery Sci and Tech.2023; 81.104209.
37. Albash R, Abdelbary A A, Refai H, EI-Nabarawi M A. Use of Transethosomes for enhancing the Transdermal delivery of Olmesartan medoxomil; In vitro, ex vivo, and in vivo evaluation. Int J of Nanomedicine. 2019; 14; 1953-1968.
38. Ferrara F, Benedusi M, Cervellati F, Sguizzato M, Montesi L, Bondi A, Drechsler M, Pula W, Valacchi G, Esposito E. Dimethyl Fumarate-loaded Transethosomes: A formulative study and preliminary Ex vivo and In vivo evaluation. Int J. mol.Sci.2022;23.8756.
39. Soliman S M, Rashwan K O, Teaima M, Jasti B R, EI- Nabarawi M A, Abdel-Haleem K M, Transethosomes as breakthrough tool for controlled transdermal delivery of Dexketoprofen trometamol: design, fabrication, statistical optimization, In vitro, and Ex vivo characterization. Int J App Pharm.2022; 14(6): 51-57.
40. Ferrara F, Benedusi M, Sguizzato M, Cortesi R, Baldisserptto A, Buzzi R, Valacchi G, Esposito E. Ethosomes and transethosomes as cutaneous delivery systems for Quercetin: A preliminary study on Melanoma cells. Pharmaceutics.2022; 14:1038.
41. Abdulbaqi I M, Darwis Y, Assi R A, Khan N A K, Transethosomal gels as carrier for the Transdermal delivery of Colchicine: statistical optimization, characterization, and Ex vivo evaluation. Drug desing dev. And therapy.2018; 12:795-813.
42. Song H, Wen J, Li H, Meng Y, Zhang Y, Zhang N, Zheng W. Enhanced transdermal permeability and drug deposition of rheumatoid arthritis via sinomenine hydrochloride-loaded antioxidant surface Transethosomes. Int J of Nanomedicine. 2019; 14:3177-3188.
43. Nousheen K, Din F U, Jamshaid H, Afza R, Khan S U, Malik M, Ali Z, Batool S, Zeb A, Yousaf A M, Almari A H, Alqahtani S, Khan S, Khan G M,. Metformin HCl-loaded Transethosomal gel; Development, Characterization, and antidiabetic potential evaluation in the diabetes-induced rat model. Drug delivery.2023; 30:1.2251720.
44. Abdallah, M.H.; Elghamry, H.A.; khalifa, N.E.; Khojali, W.M.A.; Khafagy.E.-S.; Shawky, S.; EI-Horany, H.E.-S.; EI-Housiny, S. Development and optimization of Erythromycin loaded Transethosomes cinnamon oil based emulgel for antimicrobial efficiency. Gels.2023, 9,137.
45. Ahmed, T.A.; Alzahrani, M.M.; Sirwi, A.; Alhakamy, N.A. Study the antifungal and ocular permeation of ketoconazole from ophthalmic formulation containing trans-ethosomes Nanoparticles. Pharmaceutics.2021, 13,151.
46. Farooq, M.; Usman, F; Zaib, S; Shah, H.S.; Jamil, Q.A.; Akbar Sheikh, F.; Khan, A.; Rabea, S.; Hagras, S A.A.; EI- Saber Batiha, G.; Khan I. Fabrication and evaluation of Voriconazole loaded Transethosomal gel for enhanced antifungal and ant leishmanial activity. Molecules. 2022, 27, 3347.
47. Perez J V, Cortes D M M, Gomez Y G Y, Potential use of Transethosomes as a transdermal delivery system for metabolites from chenopodium murale. Material today communication.2022;10,103165.
48. Rasool M, Mazhar D, Afzal I, Zeb A, Khan S, Ali H. In vitro In vivo characterization of miconazole nitrate loaded transethosomes for the treatment of cutaneous candidiasis. Int J of Pharm.2023; 647,123563.
49. Yurtsever A G, Ekmekcioglu A, Muftuoglu M, GungorS, Erdal M S, Formulation development and evaluation of fluvastatin loaded transethosomes characterization; stability, in vitro dermal penetration, cytotoxicity and antipsoriatic activity studies, Journal of drug Del sci and tech.2024; 91,105234.
50. Song C K, Balakrishnan P, Shim C-K, Chung S-J, Chong S, Kim D-D, A Novel carrier; Transethosomes, for enhanced skin delivery of Voriconazole: characterization and In vitro / In vivo evaluation. Colloids Surfaces B: Biointerfaces .2012; 92:299-304.
51. Nasr A M, Badawi N M, Tartor Y H, Sobhy N M, Swidan S A, Development, optimization and in vitro /in vivo evaluation of Azelaic acid transethosomal gel for Antidermatophyte activity. Antibiotics.2023; 12,707.
52. Alam P, Imran M, Jahan S, Akhtar A, Hasan Z, Formulation and characterization of Hesperidin-loaded Transethosomal gel for dermal delivery to enhance antibacterial activity: comprehensive of In Vitro, Ex Vivo, and dermatokinetic analysis. Gels.2023:9,791.
53. Jessy S, Shamika S P, Formulation development tranexamic acid loaded Transethosomal patch for Melasma. Res J of Pharm Dosage forms and technology.2022; 14(1):7-6.
54. Sundar V D, Divya P, Dhanaraju M D, Design development and characterization of tramadol hydrochloride loaded Transethosomal gel formulation for effective pain management. Indian J of Pharmaceutical education and research. 2020; 54(2s): s88-s97.
55. Varghese J, Zeenath A, Vesicular Nano carriers; A Novel approach for transdermal drug delivery. World J of Pharmacy and Pharm Sci.2021; 10(6):390-406.
56. Dehanghani M Z, Mahapatra D, Joseph TM, Transethosomes; Novel technology for skin delivery of drugs. Int J Med Pharm Sci .2021; 11(08):1-5.
57. Mohammad B S, AI Gawhari F J, Transethosomes A Novel transdermal delivery system for antifungal drugs. IJDDT.2021; 11(01):238-243.
58. Ali J, Raza R, Ameen S, Arshad A, Karim F, Akram M W, Shakir L, Transethosomes; A breakthrough system for transdermal and topical drug delivery. Pakistan Biomedical Journal .2022;5(7):354-357.
59. Halesh P, Gopinath E, Chethan K, Ganesh N S, Chandy V, Transethosomes; An effective tool in bypassing barriers for topical administration of formulation. IJCRT.2023;11(05):b92-b932.
60. Vijeta B, Radha S, Transethosomes: A Novel carrier for transcutaneous drug delivery an overview. IJPSR.2023;14(8):3769-3778.
61. Pandit D, Rathore K.S., Novel and most prominent carrier system Transethosomes for topical delivery. Pharmaceutical Resonance.2021;3(2):19-27.
62. Chowdhary P, Padmakumar A, Rengan A K, Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review. Med Comm- Biomaterials and application .2023;2: e59.1-20.
63. Munir M, Zaman M, Waqar M A, Hameed H, Riaz T, A comprehensive review on Transethosomes as a novel approach for drug delivery through transdermal route. Journal of liposome Res.2023:1-16.
64. Shyam M S, Shammika P, A review of fluconazole loaded Transethosomal gel for candidiasis. World J of Pharm Res. 2021;10(10):1197-1214.
65. Vijeta B, Mishra N, Alagusundaram M, Ultra-deformable Nanotransethosomes: A Novel tool to intensify transdermal drug delivery a review. Journal of Pharm Negative Results .2023;14(03):2024-32.
66. Raj A, Dua K, Nair R S, Chandran C S, Alex A T, Transethosomes: An ultra-deformable ethanolic vesicle for enhanced transdermal drug delivery. Chemistry and physics of lipids .2023; 255,105315.