Author(s):
Nidhi, Brijesh Kumar Duvey, Ravinder Kaur, Saloni Sharma, Anurag Bhargava
Email(s):
nidhirohillarajput2000@gmail.com , brijesh.duvey@gmail.com
DOI:
10.52711/2231-5713.2025.00024 
Address:
Nidhi, Brijesh Kumar Duvey*, Ravinder Kaur, Saloni Sharma, Anurag Bhargava
Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana.
*Corresponding Author
Published In:
Volume - 15,
Issue - 2,
Year - 2025
ABSTRACT:
Trichosanthes tricuspidata Lour, commonly known as the Three-Lobed Snake Gourd, is a medicinal plant from the Cucurbitaceae family, native to Southeast Asia. Renowned for its bioactive compounds, it has extensive applications in traditional medicine, treating ailments such as fever, inflammation, and cancer. Key bioactive compounds include triterpenoids, saponins, flavonoids, alkaloids, polysaccharides, and lectins, contributing to its anti-inflammatory, antitumor, antipyretic, antioxidant, antidiabetic, and antimicrobial properties. Despite its medicinal potential, awareness outside its native regions is limited. Modern research is increasingly validating its traditional uses, although further clinical trials are needed to fully understand its therapeutic benefits and safety profile. Objective: To evaluate the bioactive compounds, traditional uses, pharmacological activities, and therapeutic potential of Trichosanthes tricuspidata Lour (Three-Lobed Snake Gourd), with a focus on its anti-inflammatory, antioxidant, anti-cancer, anti-diabetic, anti-microbial, anti-helminthic, and gastroprotective activities, in order to provide scientific validation for its use in modern medicine and promote sustainable harvesting practices for its conservation.
Cite this article:
Nidhi, Brijesh Kumar Duvey, Ravinder Kaur, Saloni Sharma, Anurag Bhargava. Phytochemistry and Therapeutic Potential of Trichosanthes tricuspidata Lour: A Comprehensive Review. Asian Journal of Pharmacy and Technology. 2025; 15(2):151-6. doi: 10.52711/2231-5713.2025.00024
Cite(Electronic):
Nidhi, Brijesh Kumar Duvey, Ravinder Kaur, Saloni Sharma, Anurag Bhargava. Phytochemistry and Therapeutic Potential of Trichosanthes tricuspidata Lour: A Comprehensive Review. Asian Journal of Pharmacy and Technology. 2025; 15(2):151-6. doi: 10.52711/2231-5713.2025.00024 Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-2-8
REFERENCES:
1. Verma N, Garg P. Bioactive compounds and medicinal properties of Trichosanthes tricuspidata Lour. Int J Pharm Sci Res. 2014;5(12):5451-60. doi:10.13040/IJPSR.0975-8232.5(12).5451-60.
2. Pandey MM, Rastogi S, Rawat AKS. Indian traditional Ayurvedic system of medicine and nutritional supplementation. Evid Based Complement Alternat Med. 2013; 2013:376327. doi:10.1155/2013/376327.
3. Vartak VD, Gadgil M. Studies on sacred groves along the Western Ghats from Maharashtra and Goa: Role of beliefs and folklore. In: Glimpses of Indian Ethnobotany. 1981. p. 272-8.
4. Arawwawala LDAM, Thabrew I, Arambewela LSR, Fernando N, Guruge LD. Antibacterial activity of Trichosanthes cucumerina Linn. extracts. Int J Pharm Biol Arch. 2011;2(2):808–12.
5. Li MX, Yeung HW, Pan LP, Chan SI. Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro. Nucleic Acids Res. 1991;19(22):639–312.
6. Saboo SS, Thorat P, Tapadiya GG, Khadabadi S. Distribution and ancient recent medical uses of Trichosanthes species. Int J Phytopharm. 2012.
7. Bhandari S, Dobhal U, Sajwan M, Bisht NS. Trichosanthes tricuspidata Lour: A medicinally important plant. Trees Life J. 2008;3(5):14.
8. Duyfjes BEE, Pruesapan K. The genus Trichosanthes L. (Cucurbitaceae) in Thailand. Thai For Bull (Bot). 2004; 32:76-109.
9. Warrier PK, Nambiar VPK, Ramankutty C. Indian medicinal plants: A compendium of 500 species. J Pharm Pharmacol. 1994;46(11):1935. doi:10.1111/j.2042-7158. 1994.tb05722. x.
10. Li W, et al. Phytochemical compounds and bioactivities of Trichosanthes kirilowii and Trichosanthes rosthornii. Evid Based Complement Alternat Med. 2016; 2016:7534527. doi:10.1155/2016/7534527.
11. Patel M, Mahobia NK. A review on pharmacological properties of Trichosanthes species. Int J Pharm Sci Res. 2014;5(5):1610-26.
12. Pandey A, Tripathi S. Concept of standardization, extraction, and prephytochemical screening strategies for herbal drug. J Pharmacogn Phytochem. 2014;2(5):115-9.
13. Khwairakpam AD, et al. Pharmacological profile and traditional uses of Trichosanthes dioica Roxb. J Ethnopharmacol. 2018; 215:52-67.
14. Yang BY, et al. Immunomodulatory and antitumor activity of polysaccharides from Chinese medicinal herbs. Chin J Nat Med. 2014;12(4):237-44.
15. Liu B, et al. Lectins: A class of proteins with remarkable biochemical and clinical potential. Crit Rev Biotechnol. 2015;35(4):354-67.
16. Jain SK. Dictionary of Indian Folk Medicine and Ethnobotany. Deep Publications; 1991.
17. Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Bishen Singh Mahendra Pal Singh; 1993.Chopra, R. N., Nayar, S. L., & Chopra, I. C. (1956). Glossary of Indian Medicinal Plants. CSIR.
18. Bhattacharya SK, Satyan KS. Experimental methods for evaluation of psychotropic agents in rodents: I--Anti-anxiety agents. Indian J Exp Biol. 1997;35(6):565-75.
19. Ahmad N, et al. Anti-inflammatory activity of natural products: A review. Phytother Res. 2016;30(7):1102-11.
20. Tripathy PK, Kumar S, Ofoeze MA, Gouda S, Singh NR, Jena PK. Validation of traditional therapeutic claims through phytochemical screening and antibacterial assessment: A study on Mahakaal (Trichosanthes tricuspidata Lour L.) from Similipal Biosphere Reserve Forest, Odisha, India. Algerian J Nat Prod. 2022;2(3):859-79.
21. Devi AG, Prasad TB, Shyma M, Raghavendra MP. Traditional herbal remedies used for management of reproductive disorders in Wayanad District, Kerala. Int J Res Pharm Chem. 2014;4(2):333-41.
22. Tripathy PK, Jena SPK. Nutritional and medicinal values of selected wild cucurbits available in Similipal biosphere reserve forest, Odisha. Int J Pharm Sci Res. 2014;5(10):5430-7.
23. Bankar MV, Bhosle NP. Ethnobotanical survey of medicinal plants in Ajanta region (MS) India. J Pharm Biol Sci. 2017;12(6):596-604.
24. Patil US, Kutemate OG. Ethno-medicinal plants used by the Korku tribes from southern Melghat, Buldana district, Maharashtra, India in the treatment of hepatic disorders. Int J Curr Res. 2017;9(10):5908-14.
25. Juyal P, Ghildiyal JC. Medicinal phyto-diversity of Bhabar Tract of Garhwal Himalaya. J Med Plants Stud. 2013;1(6):4357.
26. Ahuja A, Jeong D, Kim MY, Cho JY. Trichosanthes tricuspidata Lour Lour. Methanol extract exhibits anti-inflammatory activity by targeting Syk, Src, and IRAK1 kinase activity. Evid Based Complement Alternat Med. 2019; 2019:1-9.
27. Weng IT, Lin YA, Chen GY, Chiang HM, Liu YJ, Chen CJ, Lan YH. (-)-β-Homoarginine anhydride, a new antioxidant and tyrosinase inhibitor, and further active components from Trichosanthes truncata. Nat Prod Res. 2020;34(16):2262-8.
28. Zhang R, Hu X, Zhang B, Wang Z, Hao C, Xin J. Whitening activity of constituents isolated from the Trichosanthes pulp. Evid Based Complement Alternat Med. 2020; 2020:1-8.
29. S S Saboo K Priyanka Thorat G G Tapadiya Evaluation of phytochemical and anticancer potential of chloroform extract of Trichosanthes tricuspidata Lour Lour roots (Cucurbitaceae) using in- vitro modelsInt J Pharm Pharm Sci2013542038
30. Kulandaivel S, Bajpai P, Sivakumar T. Antihyperglycemic activity of Trichosanthes tricuspidata Lour root extract. Bangladesh J Pharmacol. 2013;8(3):305-10.
31. B K Dubey Evaluation of phytochemical constituents and anthelmintic activity of aerial part of Trichosanthes tricuspidata Lour LourInt J Pharm Phytopharmacol Res2013321046
32. Barre JT, Bowden BF, Coll JC, De Jesus J, Victoria E, Janairo GC. A bioactive triterpene from Lantana camara. Phytochemistry. 1997;45(2):321-4.
33. Smilin Bell Aseervatham G, Sivasudha T, Suganya M, Rameshkumar A, Jeyadevi R. Trichosanthes tricuspidata Lour modulates oxidative toxicity in brain hippocampus against pilocarpine induced status epilepticus in mice. Neurochem Res. 2013; 38:1715-25.
34. Barre JT, Bowden BF, Coll JC, De Jesus J, Victoria E, Janairo GC, Ragasa CY. A bioactive triterpene from Lantana camara. Phytochemistry. 1997;45(2):321-4.
35. Smilin Bell Aseervatham G, Sivasudha T, Suganya M, Rameshkumar A, Jeyadevi R. Trichosanthes tricuspidata Lour modulates oxidative toxicity in brain hippocampus against pilocarpine induced status epilepticus in mice. Neurochem Res. 2013; 38:1715-25.
36. Gupta A, Pandey AK. Antibacterial lead compounds and their targets for drug development. In: Pandey AK, editor. Phytochemicals as Lead Compounds for New Drug Discovery. Vol. 393. Elsevier; 2020. p. 275-92.
37. Ríos JL, Escandell JM, Recio MC. New insights into the bioactivity of cucurbitacins. Stud Nat Prod Chem. 2005; 32:429-69.
38. Kaushik U, Aeri V, Mir SR. Cucurbitacins—an insight into medicinal leads from nature. Pharmacogn Rev. 2015;9(17):12-8.
39. Chen X, Bao J, Guo J, Ding Q, Lu J, Huang M, Wang Y. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer. Anti-Cancer Drugs. 2012;23(8):777-87.
40. Bartalis J, Halaweish FT. In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines. Bioorg Med Chem. 2011;19(8):2757-66.
41. Duangmano S, Sae-Lim P, Suksamrarn A, Domann FE, Patmasiriwat P. Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation. BMC Complement Altern Med. 2012;12(1):1-12.
42. Duncan KL, Duncan MD, Alley MC, Sausville EA. Cucurbitacin E-induced disruption of the actin and vimentin cytoskeletons in prostate carcinoma cells. Biochem Pharmacol. 1996;52(10):1553-60.
43. Ku JM, Kim SR, Hong SH, Choi HS, Seo HS, Shin YC, Ko SG. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Mol Cell Biochem. 2015; 409:33-43.
44. Kim SR, Seo HS, Choi HS, Cho SG, Kim YK, Hong EH, et al. Trichosanthes kirilowii ethanol extract and cucurbitacin D inhibit cell growth and induce apoptosis through inhibition of STAT3 activity in breast cancer cells. Evid Based Complement Alternat Med. 2013; 2013:1-9.
45. Nakanishi T, Song Y, He C, Wang D, Morita K, Tsukada J, et al. Autophagy is associated with cucurbitacin D-induced apoptosis in human T-cell leukemia cells. Med Oncol. 2016; 33:1-8.
46. Ku JM, Hong SH, Kim HI, Lim YS, Lee SJ, Kim M, et al. Cucurbitacin D exhibits its anti-cancer effect in human breast cancer cells by inhibiting Stat3 and Akt signaling. Eur J Inflamm. 2018;16.
47. Fang EF, Zhang CZ, Zhang L, Wong JH, Chan YS, Pan WL, et al. Trichosanthin inhibits breast cancer cell proliferation in both cell lines and nude mice by promoting apoptosis. Evid Based Complement Alternat Med. 2012;7(9):1-10.