Author(s):
Ashwini Natha Waghmode, Amruta Anil Mali, Dipali N. Hagir
Email(s):
dipalihagir5@gmail.com
DOI:
10.52711/2231-5713.2026.00007 
Address:
Ashwini Natha Waghmode1, Amruta Anil Mali2, Dipali N. Hagir3
1,2Student, Navsahyadri Instituent of Pharmacy, Pune, Maharashtra, India.
3Guide, Navsahyadri Instituent of Pharmacy, Pune, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2026
ABSTRACT:
Glycerophospholipids and plant-based components combine to generate lipid-compatible compounds in phytosomes, which are innovative delivery mechanisms. "Phyto" means plant-derived, and "some" means a structure that resembles a cell. Using this novel method, phospholipids can combine with water-soluble phytoconstituents or standardised herbal extracts to form molecular complexes that improve absorption and bioavailability. By adding polyphenols to these phospholipid-based systems, the problems caused by their poor oral absorption are resolved. Phytosomes enhance gastrointestinal absorption and raise plasma concentrations of active substances by encasing hydrophilic herbal components in a lipophilic layer. The review underscores the growing function of phytosomes in augmenting the medicinal efficacy of herbal treatments and their diverse pharmaceutical formulations, including gels, pills, creams, and suspensions.
Cite this article:
Ashwini Natha Waghmode, Amruta Anil Mali, Dipali N. Hagir. Phytosome: A Novel Drug Delivery System. Asian Journal of Pharmacy and Technology. 2026; 16(1):39-4. doi: 10.52711/2231-5713.2026.00007
Cite(Electronic):
Ashwini Natha Waghmode, Amruta Anil Mali, Dipali N. Hagir. Phytosome: A Novel Drug Delivery System. Asian Journal of Pharmacy and Technology. 2026; 16(1):39-4. doi: 10.52711/2231-5713.2026.00007 Available on: https://ajptonline.com/AbstractView.aspx?PID=2026-16-1-7
REFERENCES:
1. Kumar A, Kumar B, Singh SK, Kaur B, Singh S. A Review on Phytosomes: Novel Approach for Herbal Phytochemicals. Asian J Pharm Clin Res. 2017; 10(10):41–7.
2. Rawat S, Motwani S. Phytosomal Drug Delivery System. Int J Res Dev Pharm Life Sci. 2012; 1(3):143–50.
3. Sriya KC, Sai D, Sankar PR. Phytosomes: A Novel Approach for Herbal Phytochemicals for Enhancing Bioavailability. Int J Pharm Sci Rev Res. 2020; 60(2):21–6.
4. Pahwa R, Chetna, Saroha K, Bhardwaj BY, Kumar M, Singh I. Insights into various approaches of phytosomes for enhanced therapeutic potential of bioactives. Res J Pharm Technol. 2022; 15(9):4277–82. doi:10.52711/0974-360X.2022.00718.
5. Choubey A. Phytosome - A Novel Approach for Herbal Drug Delivery. Int J Pharm Sci Res. 2011; 2(4):807–15.
6. Khanzode NMB, Kajale NAD, Channawar NMA, Gawande NSR. Review on Phytosomes: A Novel Drug Delivery System. GSC Biol Pharm Sci. 2020; 13(1):203–11.
7. Kattyar SL, Patil PS, Patil SV, Kadam SS. Phytosomes and Recent Research on Phytosomal Drugs. Asian J Pharm Anal. 2022; 12(1):61–9.
8. Gaikwad AR, Ahire KD, Gosavi AA, Salunkhe KS, Khalkar A. Phytosome as a Novel Drug Delivery System for Bioavailability Enhancement. J Drug Deliv Ther. 2021; 11(3):138–52.
9. Elhaj Eltahir AKA, Ahad HA, Haranath C, Meharajunnisa B, Dheeraj S, Sai BN. Novel Phytosomes as Drug Delivery Systems and its Past Decade Trials. Res J Pharm Dosage Forms Technol. 2023; 15(1):51-54. doi:10.52711/0975-4377.2023.00009.
10. Gaurav V, Paliwal S, Singh A, Pandey S, Siddhiqui MA. Phytosomes: Preparation, Evaluation and Application. Int J Res Eng Sci. 2021; 9(2):35–9.
11. Danish I. Phytosome: Recent Investigation for a New Drug Delivery System. Int J Newgen Res Pharm Healthc. 2024; 2(1):163–75.
12. Singh RP, Parpani S, Narke R, Chavan R. Phytosome: Recent Advance Research for Novel Drug Delivery System. Asian J Pharm Res Dev. 2014; 2(3):15–29.
13. Gaurav V, Paliwal S, Singh A, Pandey S, Aqil M. Phytosomes: Preparation, Evaluation and Application. Int J Res Eng Sci. 2021; 9(2):35–9.
14. Upase AU, Bhusnure OG, Gholve SB, Giram PS, Wattamwar PB. A Review on Phytosome Loaded with Novel Herbal Drug. J Drug Deliv Ther. 2019; 9(3-s):765–9.
15. Poudyal A, Subba B, Bhattarai A, Regmi D, Tiwari B, Pradhan A, et al. A Comprehensive Review on Phytosomes. Int J Life Sci Pharm Res. 2022; 12(5):143–61.
16. Bhandari N, Disha D, Gupta R. Review on Phytosomes: A Novel Approach for Herbal System. YMER. 2023; 22(1):1799–806.
17. Patel J, Patel R, Khambholja K, Patel N. An Overview of Phytosomes as Herbal Drug Delivery System. Asian J Pharm Sci. 2015; 10(4):363–71.
18. Nimbalkar CK, Hatware K. Phytosomes - Novel Drug Delivery System. Indian J Drugs. 2017; 5(1):16–36.
19. Joshi G, Tiwari A, Upadhyay P. Development and Characterization of Herbosomes Complex. Indo Am J Pharm Res. 2020; 10(6):736–45.
20. Das MK, Kalita B. Phytosome: An Overview. J Pharm Sci Innov. 2013; 2(3):7–11.
21. Karole S, Gautam GK, Gupta S. Evaluation of Phytosomes for Hepatoprotective Activity. Pharma Innov J. 2019; 8(2):22–6.
22. Saritha M, Ramya A, Sonia A, Monika S, Sowmya K. Phytosomes: A Novel approach for improving the efficacy of Herbal Extracts. Research Journal of Pharmacy and Technology. 2023 Dec; 16(12):6028–6031. doi:10.52711/0974-360X.2023.00978.
23. Jadhav AI, Wadhave AA, Arsul VA, Sawarkar HS. Herbal Drug Delivery System - Phytosomes. Int J Pharm Anal. 2014; 2(5):478–86.
24. Kumar S, Baldi A, Sharma DK. Phytosomes: A Modernistic Herbal Drug Delivery. J Dev Drugs. 2020; 9(2):195.
25. Kattyar SL, Patil PS, Patil SV, Kadam SS. Phytosomes and recent research on phytosomal drugs. Asian J Pharm Anal. 2022; 12(1):61–69. doi:10.52711/2231-5675.2022.00012.
26. Chen RP, Chavda VP, Patel AB, Chen ZS. Phytosomes in Transdermal Delivery. Front Pharmacol. 2022; 13:850862.
27. Amith KB, Habbu P, Thimmasetty CK, Lakshman HC, Hullatti P, Kumar RS. Herbal Medicine and Phytosomes. Syst Rev Pharm. 2017; 8(1):5–7.
28. Vaishnavi A, Arvapalli S, Rishika PS, Jabeen S, Karunakar B, Sharma JVC. A Review on Phytosomes: Promising Approach for Drug Delivery. Int J Pharm Res Appl. 2021; 1(1):289–96.
29. Das MK, Kalita B. Phytosome: an overview. J Pharm Sci Innov. 2013; 2(3):7–11.
30. Amith KB, Habbu P, Thimmasetty CK, Lakshman HC, Hullatti P, Kumar RS. Phytosomes as Novel Drug Delivery System for Herbal Medicine – A Review. Syst Rev Pharm. 2017; 8(1):5–7.
31. Chen RP, Chavda VP, Patel AB, Chen ZS. Phytochemical Delivery Through Transferosome (Phytosome): An Advanced Transdermal Drug Delivery for Complementary Medicines. Front Pharmacol. 2022; 13:850862.
32. Kaur G, Kaur P, Madaan P, Verma R, Chandel P. Recent Trends and Future Prospects of Phytosomes: A Concise Review. Int J Pharm Sci Res. 2021; 12(9):457–63.
33. Djekic L, Krajisnik D, Micic Z. Polyphenolics-Phospholipid Complex: Phytosome Technology for Herbal Drug Delivery. Crit Rev Ther Drug Carrier Syst. 2015; 32(2):159–93.
34. Singh RP, Wadhwa G, Sharma PK. Advanced Herbal Drug Delivery Systems: An Overview. Int J Pharm Pharm Sci. 2019; 11(6):1–6.
35. Goyal M, Bhaduka N, Nagar M, Dube A. Review on Herbal Drug Delivery System Based on Phytosomes. Int J Curr Pharm Res. 2020; 12(4):10–15.
36. Gupta M, Chauhan DN, Sharma V, Chauhan NS. Phytosomes and Herbal Phytoconstituents: A Review. Asian J Pharm Res Dev. 2021; 9(2):20–8.
37. Waghmode AN, Shinde VM, Patil RH. Review on Characterization of Phytosomes and Herbal Drug Delivery System. Int J Drug Dev Res. 2020; 12(2):180–7.
38. Tiwari R, Agrawal S, Jaiswal S. Preparation and Evaluation of Phytosomes of Punica granatum. Int J Pharm Sci Res. 2021; 12(5):253–9.
39. Kakarla B, Krishna S, Elumalai A, Eswaraiah MC. Phytosomes - An overview on scientific rebellion in phytomedicine. Res J Topical Cosmet Sci. 2012; 3(2):56–59
40. Chavan SB, Yadav AV. Design, Development and Characterization of Phytosomes for Improved Bioavailability of Rutin. Int J Drug Dev Res. 2018; 10(2):37–44.
41. Selvaraju K, Arulkumaran KSG, Karthick K, Vengadesh Prabhu K, Padma Preetha J, Arrivukkarasu R. Phytosomes – An Advanced Herbal Technology. Res J Pharmacogn Phytochem. 2011; 3(5):191–4.
42. Sheikh S, Ali SA. Characterization and Evaluation of Phytosomes: A Review. J Pharmacogn Phytochem. 2020; 9(3):3423–9.
43. Bhise S, Waghmode A. Novel Carrier System: Phytosomes. Asian J Pharm Res. 2019; 9(1):1–9.
44. Mehta M, Nayak M. Spectroscopic Evaluation in Phytosome Complexes. Int J Pharm Pharm Sci. 2022; 14(1):112–7.
45. Vyas M, Patel N. Evaluation of Antioxidant and Hepatoprotective Properties of Phytosome Formulation. Res J Pharm Biol Chem Sci. 2020; 11(3):455–60.
46. Pawar HA, Chaudhari SY. Analytical Methods for Herbal Formulations. J Drug Deliv Ther. 2018; 8(6):402–7.
47. Patel CJ, Tyagi S, Patel P, Yadav A. Phytosomes: A Current Trend for Enhancement of Bioavailability of Polar Phytoconstituents. Res J Pharm Dosage Form Tech. 2014; 6(1):44–49.
48. Shah P, Patel B. Surface Tension Studies in Phytosomes. Asian J Pharm Clin Res. 2021; 14(4):95–101.
49. Rayate Y, Shewale S, Patil A, Nitalikar M, Mohite S. Phytosomes–A novel approach in herbal drug delivery system. Asian J Res Pharm Sci. 2018; 8(3):151-154. doi:10.5958/2231-5659.2018.00027.9.
50. Gajbhiye RK, Waghmode AN. FTIR and Compatibility Studies in Phytosome Formulation. Int J Pharm Biol Sci. 2020; 10(2):74–80.
51. Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK. Enhanced therapeutic benefit of silymarin–phospholipid complex. Iran J Pharm Res. 2005; 4(3):132–138.
52. Semalty A, Semalty M, Rawat MS. Development and evaluation of phytosomes of curcumin. J Pharm Res. 2010; 3(4):788–793.
53. Yanyu X, Yunmei S, Zhipeng C, Qineng P. The preparation of green tea phytosomes and their antioxidant effects. Int J Pharm. 2006; 307(1):77–82.
54. Bombardelli E, Morazzoni P. Phytosome in Ginkgo biloba extract. Fitoterapia. 1991; 62(1):1–6.
55. Bhattacharya S. Phytosomes: emerging strategy in delivery of herbal drugs and nutraceuticals. Pharm Times. 2009; 41(3):9–12.
56. Jain S, Bhargava V, Jain A, Jatav N, Prasad P. Phytosome: a revolution in herbal drug delivery. Int J Pharm Sci Rev Res. 2010; 4(3):69–74.
57. Das S, Das MK. Evaluation of Boswellia serrata extract loaded phytosomes for arthritis. J Appl Pharm Sci. 2012; 2(11):30–35.
58. Sharma DK. Therapeutic Benefits and Applications of Phytosomes. J Dev Drugs. 2020; 9(1):105–11.
59. Sawarkar HS, Jadhav AI. Phytosomes for Improved Bioavailability of Herbal Extracts. Int J Pharm Anal. 2014; 2(3):98–103.
60. Salunkhe KS, Ahire KD. Protein and Peptide Delivery Using Phytosomes. J Pharm Sci Res. 2019; 11(5):2101–5.
61. Khan Z, Khatik R. Phytosomes in Cosmetic Formulations. J Cosmet Dermatol Sci Appl. 2022; 12(2):85–91.
62. Patel MJ, Shah RR. Hepatoprotective Effects of Herbal Phytosomes. Asian J Pharm Clin Res. 2021; 14(2):101–7.
63. Chen R, Chavda VP. Cosmeceutical Applications of Phytosomes. Front Pharmacol. 2022; 13:950113.
64. Tiwari R, Jaiswal S. Toxicological Evaluation of Phytosomes. Int J Curr Pharm Res. 2020; 12(6):25–30.
65. Goyal M, Gupta R. Future Perspectives of Phytosomes. J Pharm Sci Res. 2021; 13(4):180–5.
66. Chavda VP, Patel AB. Phytosomes: Bridging Traditional and Modern Herbal Drug Delivery. Front Pharmacol. 2022; 13:880701.
67. Kattyar SL, Patil PS, Patil SV, Kadam SS. Phytosomes and Recent research on Phytosomal Drugs. Asian J Pharm Anal. 2022; 12(1):61-69. doi:10.52711/2231-5675.2022.00012
68. Selvaraju K, Arulkumaran KSG, Karthick K, Vengadesh Prabhu K, Padma Preetha J, Arrivukkarasu R. Phytosomes – An advanced herbal technology. Res J Pharmacogn Phytochem. 2011; 3(5):191–4.