Antioxidant and Hepatoprotective properties of Terminalia arjuna Bark on Isoniazid Induced Toxicity in Albino rats

P. Doorika; T. Ananthi

Asian Journal of Pharmacy and Technology

ISSN

2231-5713 (Online)
2231-5705 (Print)

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Antioxidant and Hepatoprotective properties of Terminalia arjuna Bark on Isoniazid Induced Toxicity in Albino rats

Author(s): P. Doorika, T. Ananthi

Email(s): elangani576@ gmail.com

DOI: Not Available

Address: P. Doorika and T. Ananthi*
P.G. Department of Biochemistry, S.T.E.T Women’s College, Mannargudi – 614 601.
*Corresponding Author

Published In: Volume - 2, Issue - 1, Year - 2012

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ABSTRACT:
The aqueous extract of Terminalia arjuna bark was investigated for its hepatoprotective effect against isoniazid induced acute liver damage on albino rats. Isoniazid (100mg/kg) significantly elevated the serum levels of biochemical markers like SGPT, SGOT, ALP, ACP, Bilirubin, Protein and depleted antioxidant enzymes GSH and SOD upon administration of Isoniazid (100mg/kg) to albino rats. This indicated that there the aqeous extract of bark of Terminalia arjuna at 200mg/kg dose significantly reduced the elevated levels of biochemical markers mentioned above. Test extract treatment also increased the level of SOD and GSH. These results suggest that aqueous extract of Terminalia arjuna may have the potential therapeutic value in the treatment of Isoniazid induced hepatic damage and some liver diseases. Hepatoprotective activity of the study plant may be attributed to the anti-oxidant principles in it.

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Cite this article:
P. Doorika , T. Ananthi. Antioxidant and Hepatoprotective properties of Terminalia arjuna Bark on Isoniazid Induced Toxicity in Albino rats. Asian J. Pharm. Tech. 2(1): Jan.-Mar. 2012; Page 15-18.

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DOI: 10.5958/2231–5713