Author(s): Pratiksha Sonawale, Amol Patil, Asmit Kamble, Mangesh Bhutkar

Email(s): amp1216@rediffmail.com

DOI: Not Available

Address: Pratiksha Sonawale1*, Amol Patil2, Asmit Kamble2, Mangesh Bhutkar2
1Gauri Shankar Institute of Pharmaceutical Education and Research Limb, Satara
2Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa, Dist- Satara
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2016


ABSTRACT:
Approximately more than 50%of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. The bioavailability of these drugs (BCS class II) is rate-limited by its dissolution, so that even a small increase in dissolution rate sometimes results in a large increase in bioavailability. The rate and extent of absorption of class II compounds is highly dependent on the performance of the formulated product. Self-microemulsifying drug delivery systems (SMEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Conventional SMEDDS, however, are mostly prepared in a liquid form, which can produce some disadvantages. Accordingly, solid SMEDDS (S-SMEDDS), prepared by solidification of liquid/semisolid self-emulsifying (SE) ingredients into powders, have gained popularity. This article presents an account on types of self-emulsifying formulations with emphasis on formulation of solid dosage forms, characterization and in- vitro analysis.


Cite this article:
Pratiksha Sonawale, Amol Patil, Asmit Kamble, Mangesh Bhutkar. Solubility Enhancement of Lipophilic Drugs - Solid Self Micro-Emulsifying Drug Delivery System. Asian J. Pharm. Tech. 2016; 6 (3): 155-158.


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DOI: 10.5958/2231–5713 


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