Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form

Syed Sagheer Ahamed; Mohamed Khaleel; Nirmal. T. Havannavar; Syed Shariff Miyan

doi:10.5958/2231-5713.2019.00042.4

Asian Journal of Pharmacy and Technology

ISSN

2231-5713 (Online)
2231-5705 (Print)

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Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form

Author(s): Syed Sagheer Ahamed, Mohamed Khaleel, Nirmal. T. Havannavar, Syed Shariff Miyan

Email(s): hapsagheer@gmail.com , Helloprofessor4610@.COM

DOI: 10.5958/2231-5713.2019.00042.4

Address: Syed Sagheer Ahamed*1, Mohamed Khaleel2, Nirmal. T. Havannavar3, Syed Shariff Miyan4
Department of Pharmaceutical Analysis and Quality Assurance, M.M.U College of Pharmacy, Ramanagara
*Corresponding Author

Published In: Volume - 9, Issue - 4, Year - 2019

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ABSTRACT:
A simple, sensitive and accurate colorimetric estimation method was developed for the assay of Nebivolol hydrochloride in pure drug and tablet dosage form. The yellowish-orange coloured chromogen so produced was measured at 392nm for Nebivolol hydrochloride. It obeyed beer’s law at the concentrations of 4-36µg/ml with coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 2.558µg/ml and Limit of quantitation (LOQ) was found to be 3.764µg/ml. Validation of the method yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness. The excipients found in the formulation did not hamper the method.

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Cite this article:
Syed Sagheer Ahamed, Mohamed Khaleel, Nirmal. T. Havannavar, Syed Shariff Miyan. Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Pharm. Tech. 2019; 9(4):253-259. doi: 10.5958/2231-5713.2019.00042.4

Cite(Electronic):
Syed Sagheer Ahamed, Mohamed Khaleel, Nirmal. T. Havannavar, Syed Shariff Miyan. Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Pharm. Tech. 2019; 9(4):253-259. doi: 10.5958/2231-5713.2019.00042.4 Available on: https://ajptonline.com/AbstractView.aspx?PID=2019-9-4-4

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DOI: 10.5958/2231–5713