Author(s): Syed Sagheer Ahamed, Mohamed Khaleel, Nirmal. T. Havannavar, Syed Shariff Miyan

Email(s): hapsagheer@gmail.com , Helloprofessor4610@.COM

DOI: 10.5958/2231-5713.2019.00042.4   

Address: Syed Sagheer Ahamed*1, Mohamed Khaleel2, Nirmal. T. Havannavar3, Syed Shariff Miyan4
Department of Pharmaceutical Analysis and Quality Assurance, M.M.U College of Pharmacy, Ramanagara
*Corresponding Author

Published In:   Volume - 9,      Issue - 4,     Year - 2019


ABSTRACT:
A simple, sensitive and accurate colorimetric estimation method was developed for the assay of Nebivolol hydrochloride in pure drug and tablet dosage form. The yellowish-orange coloured chromogen so produced was measured at 392nm for Nebivolol hydrochloride. It obeyed beer’s law at the concentrations of 4-36µg/ml with coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 2.558µg/ml and Limit of quantitation (LOQ) was found to be 3.764µg/ml. Validation of the method yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness. The excipients found in the formulation did not hamper the method.


Cite this article:
Syed Sagheer Ahamed, Mohamed Khaleel, Nirmal. T. Havannavar, Syed Shariff Miyan. Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Pharm. Tech. 2019; 9(4):253-259. doi: 10.5958/2231-5713.2019.00042.4


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DOI: 10.5958/2231–5713 


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