Author(s): Neha Kumari, Ruchika Sharma


DOI: 10.5958/2231-5713.2020.00027.6   

Address: Neha Kumari*, Ruchika Sharma
Sri Sai College of Pharmacy, Badhani, Pathankot-145001.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2020

In many formulations, we start moving towards the Ayurvedic powders and other excipients, although it is good because the chances of adulteration can be decrease and patient compliance can be increased. And Immediate Release Tablets are those tablets which are designed to disintegrate and release their medication with no special rate controlling features, such as special coatings and other techniques. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer, has quick onset of action is economical and lead to better patient compliance. In this research work on immediate release tablet Carvedilol and natural superdisintegrants (fenugreek seed mucilage) were prepared by wet granulation method. When work is started, Preformulation studies show us that powder blend is not having floating nature. Formulation was optimized and prepare under minimum possible disintegrating time. Tablets then further evaluated for FT-IR, solubility, hardness, weight variation, friability, wetting time, In vitro process, and for this we design nine formulations. In first three there is a Crospovidone, another three contain natural superdisintegrant (fenugreek seed mucilage), and for last three contain SSG. All were gone through pre and post compression method. All the prepared formulations show significant result obtained by Pharmacopoeia quality control test. On the basis of disintegration test observations F3 and F6 formulation were found to be best among all batches.

Cite this article:
Neha Kumari, Ruchika Sharma. An Immediate Release tablet of Carvedilol with Natural Superdisintegrants Fenugreek seed Mucilage and synthetic Superdisintegrants. Asian J. Pharm. Tech. 2020; 10(3):156-164. doi: 10.5958/2231-5713.2020.00027.6

Neha Kumari, Ruchika Sharma. An Immediate Release tablet of Carvedilol with Natural Superdisintegrants Fenugreek seed Mucilage and synthetic Superdisintegrants. Asian J. Pharm. Tech. 2020; 10(3):156-164. doi: 10.5958/2231-5713.2020.00027.6   Available on:

1. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Philadelphia: Lea and Febiger; 1976.
2. Zisaki A, Miskovic L, Hatzimanikatis V. Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches. Current pharmaceutical design. 2015 Feb 1; 21(6):806-22.
3. Abdelbary G, Prinderre P, Eouani C, Joachim J, Reynier JP, Piccerelle PH. The preparation of orally disintegrating tablets using a hydrophilic waxy binder. International journal of pharmaceutics. 2004 Jul 8; 278(2):423-33.
4. Ghosh T, Ghosh A, Prasad D. A review on new generation orodispersible tablets and its future prospective. Int j pharm pharm sci. 2011 Jan;3(1):1-7.
5. Bhowmik D, Chiranjib B, Krishnakanth P, Chandira RM. Fast dissolving tablet: an overview. Journal of chemical and pharmaceutical research. 2009; 1(1):163-77.
6. Tablet FD. An Overview. Journal of Chemical and Pharmaceutical Research. 2009; 1(1):163-77.
7. Liang AC, Chen LL. Fast-dissolving intraoral drug delivery systems. Expert opinion on therapeutic patents. 2001 Jun 1; 11(6):981-6.
8. Pradeep HK. Design and in vitro evaluation of mouth dissolving tablets of venlafaxine hydrochloride (Doctoral dissertation, RGUHS).
9. Kuno Y, Kojima M, Ando S, Nakagami H. Evaluation of rapidly disintegrating tablets manufactured by phase transition of sugar alcohols. Journal of controlled release. 2005 Jun 20; 105(1-2):16-22.
10. Barnett HJ, Taylor DW, Eliasziw M, Fox AJ, Ferguson GG, Haynes RB, Rankin RN, Clagett GP, Hachinski VC, Sackett DL, Thorpe KE. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. New England Journal of Medicine. 1998 Nov 12; 339(20):1415-25. 
11. Manivannan R. Oral disintegrating tablets: A future compaction. Drug Invention Today. 2009 Nov 1; 1(1):61-5.
12. Velmurugan S, Vinushitha S. Oral disintegrating tablets: An overview. International Journal of Chemical and Pharmaceutical Sciences. 2010 Dec;1(2):1-2.
13. Khokhar P, Shukla V. Formulation and evaluation of fast dissolving tablets of diclofenac sodium using PVP. International Journal of Pharma Research and Review. 2014 Jul; 7:12-9.
14. Aarti J, Sonali J, Ganesh D. Orodispersible Tablets: A Comprehensive Review. Research Journal of Pharmacy and Technology. 2014 Mar 1;7(3):8.
15. Sahoo S, Mishra B, Biswal PK, Panda O, Mahapatra SK, Jana GK. Fast Dissolving Tablet: As a potential drug delivery system. Drug invention today. 2010 Feb 1; 2(2):130-3.
16. Reddy LH, Ghosh B. Fast dissolving drug delivery systems: A review of the literature. Indian journal of pharmaceutical sciences. 2002; 64(4):331.
17. Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2004; 21(6).
18. Zhao N, Augsburger LL. Functionality comparison of 3 classes of superdisintegrants in promoting aspirin tablet disintegration and dissolution. AAPS pharmscitech. 2005 Dec 1; 6(4): E634-40.
19. Perissutti B, Rubessa F, Moneghini M, Voinovich D. Formulation design of carbamazepine fast-release tablets prepared by melt granulation technique. International journal of pharmaceutics. 2003 Apr 30; 256(1-2):53-63.
20. Bokshi B, Malakar A. Formulation and evaluation of Allylestrenol immediate release tablets. IJPSR. 2012 Jun 1; 3(6):1679-83.
21. Yeole CN, Darekar SS, Amit Gupta GS. Formulation and evaluation of immediate release tablet of Paroxetine hydrochloride. Journal of pharmacy research. 2010 Aug; 3(8):1736-8.
22. Hu RF, Zhu JB, Peng DY, Tang JH, Zhou A. Optimization of formulation of Fufang Danshen immediate release tablet by colligation score. Zhongguo Zhong yao za zhi Zhongguo zhongyao zazhi China journal of Chinese materia medica. 2006 Mar; 31(5):380-2.
23. Chandira RM, Thakor Pranavkumar P, Kumudhavalli MV. Formulation evaluation and development of sustained release tablets of indapamide and immediate release blend of ramipril in capsules.
24. Bagde SB, Bakde BV, Channawar MA, Chandewar AV. Formulation and evaluation of bi layer tablet of metoprolol succinate and Ramipril. Int J Pharm Pharm Res. 2011; 6:1416-28.
25. Sekar V, Chellan VR. Immediate release tablets of telmisartan using superdisintegrant-formulation, evaluation and stability studies. Chemical and Pharmaceutical Bulletin. 2008 Apr 1; 56(4):575-7.
26. Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, Shusterman NH. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. New England Journal of Medicine. 1996 May 23; 334(21):1349-55.
27. Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, Lubsen J, Lutiger B, Metra M, Remme WJ, Torp-Pedersen C. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET): randomised controlled trial. The Lancet. 2003 Jul 5; 362(9377):7-13.
28. Capricorn Investigators. Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. The Lancet. 2001 May 5; 357(9266):1385-90.

Recomonded Articles:

Author(s): Hafsa, Asfa, Nuha Rasheed, Abdul Saleem Mohammad

DOI: 10.5958/2231-5713.2017.00001.0         Access: Open Access Read More

Author(s): Manohar D. Kengar, Rohit S. Howal, Dattatray B. Aundhakar, Amit V. Nikam, Priyajit S. Hasabe

DOI: 10.5958/2231-5713.2019.00010.2         Access: Open Access Read More

Author(s): Ruchika Sharma, M. S. Ashawat, C. P. S Verma, Neha Kumari

DOI: 10.5958/2231-5713.2020.00039.2         Access: Open Access Read More

Author(s): Yogita. Chowdhary

DOI: 10.5958/2231-5713.2018.00002.8         Access: Open Access Read More

Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

DOI: 10.5958/2231-5713.2018.00001.6         Access: Open Access Read More

Author(s): Abhishek S. Pujari, Nitin A. Gaikwad, Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane

DOI: 10.5958/2231-5713.2018.00019.3         Access: Open Access Read More

Author(s): Anju govind, Manjunath B Menden, Ravikumar, Simila1, Mercy, Narayana Swamy VB

DOI: 10.5958/2231-5713.2016.00013.1         Access: Open Access Read More

Author(s): Pawar P.B., M.P. Wagh, S.N. Bhandare

DOI:         Access: Open Access Read More

Author(s): Himanshu Deshmkh, Chandrashekhara S., Nagesh C., Amol Murade, Shridhar Usgaunkar.

DOI:         Access: Open Access Read More

Author(s): K. Vanitha. M. Venkataswamy, Sanam Niharika, Alluri Ramesh

DOI: 10.5958/2231-5713.2018.00011.9         Access: Open Access Read More

Author(s): Yogita Rayate, Shrinivas Mohite, Shital Shewale, Aishwarya Patil

DOI: 10.5958/2231-5713.2019.00005.9         Access: Open Access Read More

Author(s): Sampada V. Kadam, Nilima U. Rane, Chandrakant S. Magdum

DOI: 10.5958/2231-5713.2019.00011.4         Access: Open Access Read More

Author(s): Neha Srivastava, Seema Thakur, Anchal Bajaj, Nikita Sahi

DOI:         Access: Open Access Read More

Author(s): S. Kumara Swamy, G. Arun, Bethi Srinivas, Agaiah Goud B

DOI: 10.5958/2231-5713.2016.00014.3         Access: Open Access Read More

Author(s): Rohan Patil, Neha Patil, Aniket Patil , S. J. Shid, V.N. Dange, C.S. Magdum, S.K. Mohite

DOI: 10.5958/2231-5713.2016.00026.X         Access: Open Access Read More

Author(s): Rajeshree Panigrahi, K.A. Chowdary, Gitanjali Mishra, Manas Bhowmik, Saiprasanna Behera

DOI:         Access: Open Access Read More

Author(s): Sapana Ahirrao, Bhagyashree D. Gangode, Sanjay Kshirsagar

DOI: 10.5958/2231-5713.2017.00030.7         Access: Open Access Read More

Author(s): Sarfaraz Md., Arshad Ahmed Khan K., Doddayya H., Reddy S.R. , Udupi R.H.

DOI:         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 

Recent Articles