Author(s): Mahendra Prajapati, Shradha Shende, Vivek Jain, Akhil Gupta, Manoj Kumar Goyal

Email(s): rahuljadhav600@gmail.com

DOI: 10.52711/2231-5713.2021.00044   

Address: Mahendra Prajapati1*, Shradha Shende1, Vivek Jain1, Akhil Gupta2, Manoj Kumar Goyal2
1NRI Institute of Pharmacy, Bhopal (M.P.)
2Jai Institute of Pharmaceutical Sciences and Research, Gwalior (M.P.)
*Corresponding Author

Published In:   Volume - 11,      Issue - 4,     Year - 2021


ABSTRACT:
The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 and F-15 were selected for further studies. Though F-16, F-17, F-18, F-19 and F-20 formulations are also stable, but rejected due to high concentration of surfactant can cause skin irritation, skin burning and/or other complications. Characterization of selected voriconazole microemulsion formulations were evaluated under various parameters like Droplet size, Zeta potential, Poly Dispersity Index (PDI) and (%) Drug content all results showed.


Cite this article:
Mahendra Prajapati, Shradha Shende, Vivek Jain, Akhil Gupta, Manoj Kumar Goyal. Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel. Asian Journal of Pharmacy and Technology. 2021; 11(4):267-2. doi: 10.52711/2231-5713.2021.00044

Cite(Electronic):
Mahendra Prajapati, Shradha Shende, Vivek Jain, Akhil Gupta, Manoj Kumar Goyal. Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel. Asian Journal of Pharmacy and Technology. 2021; 11(4):267-2. doi: 10.52711/2231-5713.2021.00044   Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-4-2


REFERENCE:
1.    Anna Kogan, Nissim Garti (2006). “Microemulsions as transdermal drug delivery vehicles” Advances in Colloid and Interface Science Volumes 123–126, 16 November, Pages 369-385.
2.    Kumar. K. Senthil et al. (2011). Microemulsions as Carrier for Novel Drug Delivery: A Review. International Journal of Pharmaceutical Sciences Review and Research; 10: 37-45.
3.    Patel R. Mrunali (2007). Microemulsions: As Novel Drug Delivery Vehicle; 5.
4.    Madhav. S and Gupta. D. (2011). A review on microemulsion based system. International Journal of Pharmaceutical Sciences and Research; 2 (8): 1888.
5.    Vyas S P (2009). Theory and practice in novel drug delivery system. CBS Publishers New Delhi.; p115.
6.    Prince L. M. (1976). A theory of aqueous emulsions I. Negative interfacial tension at the oil/water interface. Journal of Colloid and Interface Science; 23: 165- 173.
7.    Carter SJ (2000). Disperse system In: Cooper and Gunn’s Tutorial Pharmacy. 6thed. New Delhi: CBS Publishers and Distributors; 68-72.
8.    Todd RH, Daniel SK. (2008). Hydrogels in drug delivery: progress and challenges. Polymer; 49: 1993-3007.
9.    Ahmed EM. (2013). Hydrogel: Hydrogel: Preparation, characterization, and applications, J Adv Res .07.006.
10.    Rangasamy et al (2013)., International Current Pharmaceutical Journal, September, 2(10): 165-169

Recomonded Articles:

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): G. Baskar, J. Chandhuru, K. Sheraz Fahad, A.S. Praveen

DOI:         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): K. Vanitha. M. Venkataswamy, Sanam Niharika, Alluri Ramesh

DOI: 10.5958/2231-5713.2018.00011.9         Access: Open Access Read More

Author(s): Pratiksha Sonawale, Amol Patil, Asmit Kamble, Mangesh Bhutkar

DOI:         Access: Open Access Read More

Author(s): Kaviyarasi K., Kanimozhi K., Madhanraj P, Panneerselvam A., Ambikapathy V.

DOI:         Access: Open Access Read More

Author(s): D. M. Shinkar, A. N. Patil , R. B. Saudagar

DOI: 10.5958/2231-5713.2017.00011.3         Access: Open Access Read More

Author(s): R.B. Saudagar, S. Samuel

DOI: 10.5958/2231-5713.2016.00019.2         Access: Open Access Read More

Author(s): Agnes Nuniek Winantari1, Dwi Setyawan, Siswandono, Sundani Nurono Soewandhi

DOI: 10.5958/2231-5713.2017.00006.X         Access: Open Access Read More

Author(s): K. Hemalatha, D. Niranjan Raj, M. Fousia Begam, Sharanya. V.K., K. Girija

DOI: 10.5958/2231-5713.2017.00019.8         Access: Open Access Read More

Author(s): Raut Indrayani D, Gharge Manisha, Dandwde Sonli, Mohite S.K., Magdum C.S.

DOI: 10.5958/2231-5713.2017.00008.3         Access: Open Access Read More

Author(s): Nitin A. Gaikwad, Abhishek S. Pujari , Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane

DOI: 10.5958/2231-5713.2019.00017.5         Access: Open Access Read More

Author(s): Poonam M. Lalwani, S.D. Barhate, M.M. Bari

DOI: 10.5958/2231-5713.2018.00021.1         Access: Open Access Read More

Author(s): Shashikant Chandrakar, Amit Roy, Ananta Choudhury, Suman Saha, Sanjib Bahadur, Pushpa Prasad

DOI:         Access: Open Access Read More

Author(s): Kanchan R. Pagar, Sarika V. Khandbahale

DOI: 10.5958/2231-5713.2019.00023.0         Access: Open Access Read More

Author(s): Manohar D. Kengar, Amit A. Jadhav, Suraj B. Kumbhar, Rahul P. Jadhav

DOI: 10.5958/2231-5713.2019.00020.5         Access: Open Access Read More

Author(s): Ashish Kute, Prakash Goudanavar, Doddayya Hiremath, S.R. Reddy

DOI:         Access: Open Access Read More

Author(s): Sujata S. Sawant, Sangram S. Patil, Hemant S. Kandle, Manohar D. Kengar, Ganesh B. Vambhurkar, Mangesh A. Bhutkar

DOI: 10.5958/2231-5713.2019.00029.1         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags