Author(s): Sandhya Potdar, Vidyaranee Ingale, Nilesh Kulkarni, Manojkumar Munde, Shashikant Dhole

Email(s): sandhyapotdar2803@gmail.com

DOI: 10.52711/2231-5713.2022.00022   

Address: Sandhya Potdar, Vidyaranee Ingale, Nilesh Kulkarni, Manojkumar Munde, Shashikant Dhole
Department of Pharmaceutics, PES Modern College of Pharmacy (For Ladies), Moshi, Pune, Maharashtra, India. Affiliated to Savitribai Phule Pune University, Pune, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2022


ABSTRACT:
Nanosponges are the recent advances in nanotechnology. Nanosponge delivery system was originally developed for topical drug delivery. Nowadays it can also be used for oral delivery of drugs using water soluble and bio erodible polymers. Nanosponges are porous structures with a size of about a virus (average diameter below 1µm). Due to small size and porous nature; nanosponges can bind to poorly soluble drugs and improves their bioavailability. These nanosponges can circulate within body and interact with specific target site. At target site start releasing the drug in a controlled manner. Various techniques are reported for the preparation of Nanosponges as melt method, solvent diffusion method, solvent method, ultrasound assisted method and sonication etc. Nanosponges are the target specific drug delivery which has lesser side effects. Major advantage of nanosponges as it improves solubility of poorly soluble drug and exhibits higher drug loading as compared to other nanocarriers. This review gives the highlights about the formulation methods, excipients used, evaluation of nanosponges and its benefits to overcome the undesirable properties of drug into desirable.


Cite this article:
Sandhya Potdar, Vidyaranee Ingale, Nilesh Kulkarni, Manojkumar Munde, Shashikant Dhole. Insight on Development and Evaluation of Nanosponge Drug Delivery for improved Therapeutic effectiveness. Asian Journal of Pharmacy and Technology. 2022; 12(2):129-5. doi: 10.52711/2231-5713.2022.00022

Cite(Electronic):
Sandhya Potdar, Vidyaranee Ingale, Nilesh Kulkarni, Manojkumar Munde, Shashikant Dhole. Insight on Development and Evaluation of Nanosponge Drug Delivery for improved Therapeutic effectiveness. Asian Journal of Pharmacy and Technology. 2022; 12(2):129-5. doi: 10.52711/2231-5713.2022.00022   Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-2-8


REFERENCES:
1.    Jagtap SR, Bhusnure OG, Mujewar IN, Gholave SB, Panchabai VB. A Novel Trend For targeted drug delivery. Journal of drug delivery and therapeutics. 2019; 9 (3-s): 931-938. https://doi.org/10.22270/jddt.v9i3-s.2864
2.    Balwe MB. (2020). Nanosponge A Novel Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology. 12(4). 261-266. Available on: https://rjpdft.com/AbstractView.aspx?PID=2020-12-4-5
3.    Iriventi P, Gupta N.V. Development and evaluation of nanosponge loaded topical herbal gel of Wrightia tinctoria. International Journal of Applied Pharmaceutics. 2020; 12 (1). 89-95. https://doi.org/10.22159/ijap.2020v12i1.31198
4.    Abbas N, Irfan M, Hussain A, Arshad MS, Hussain SZ, Latif S, Bukhari NI. Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen. Tropical Journal of Pharmaceutical Research. 2018; 17(8). 1465-1474. DOI: 10.4314/tjpr.v17i8.2
5.    Kumar PS, Hematheerthani N, Ratna JV, Saikishore V. Design and characterization of miconazole nitrate loaded nanosponges containing vaginal drug delivery. Indo American Journal of Pharmaceutical sciences. 2016; 2(6). 1028-1037.
6.    Mane PK, Alookar NH. Development, Characterization and evaluation of nanosponge gel containing Flurbiprofen as a non-steroidal anti-inflammatory drug. Pharmaceutical Resonance. 2021; 3(2). 80-92.
7.    Raja CH. N. V, Kumar GK, Kotapati A. Fabrication and evaluation of ciprofloxacin loaded nanosponges for sustained release. International Journal of Research in Pharmaceutical and Nanosciences. 2013; 2(1). 1-9. http://www.ijrpns.com/article/Fabrication%20and%20evaluation%20OF%20ciprofloxacin%20loaded%20nanosponges%20for%20sustained%20release_pdf.pdf
8.    Reddy N, Parusha S, Ayyanna, Lavanya, Kumar U, Priyanka. Fabrication and characterization of itraconazole loaded nanosponge gel. World journal of pharmaceutical research. 2019; 8(5); 1184–1204. DOI : 10.20959/wjpr20195-14701
9.    Aldawsari HM, Badr-Eldin SM, Labib GS, El-Kamel AH. Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation. International journal of nanomedicine. 2015; 10: 893.
10.    Abass MM, Rajab NA. Preparation and characterization of etodolac as a topical nanosponges hydrogel. Iraqi Journal of Pharmaceutical Sciences. 2019; 28 (1); 64-74. https://doi.org/10.31351/vol28iss1pp64-74
11.    Silpa GS, Mathan S, Dharan SS. Formulation and Evaluation of Nanosponges Loaded Hydrogel Using Different Polymers Containing Selected Antifungal Drug. Journal of Pharmaceutical Sciences and Research. 2021; 13 (2); 101-11.
12.    Gawali CH, Junagade MS. Formulation and Evaluation of Nanosponges Loaded Hydrogel of Tizanidine Hydrochloride. World Journal of Pharmaceutical Research. 2019; 8 (8): 559-574. DOI: 10.20959/wjpr20198-15207.
13.    Mohammed Muqtader Ahmed, Farhat Fatima, Md. Khalid Anwer, Elmutasim Osman Ibnouf, Mohd Abul Kalam, Aws Alshamsan, Mohammed F. Aldawsari, Ahmed Alalaiwe, Mohammad Javed Ansari, Formulation and in vitro evaluation of topical nanosponge-based gel containing butenafine for the treatment of fungal skin infection, Saudi Pharmaceutical Journal, Volume 29, Issue 52021; 29 (5): 467-477,https://doi.org/10.1016/j.jsps.2021.04.010.
14.    Pandey J, Singh A. Formulation and Evaluation of Nanosponge Based Controlled Release Topical Gel Preparation of Ketoconazole. International Journal of Pharmacy and Pharmaceutical research. 2018; 12 (3); 367-382.
15.    Srinivas P, Reddy A. Formulation and evaluation of isoniazid loaded nanosponges for topical delivery. Pharmaceutical Nanotechnology. 2015; 3 (1); 68-76. 10.2174/2211738503666150501003906
16.    Mane PK, Alookar NH. Development, Characterization and evaluation of nanosponge gel containing Flurbiprofen as a non-steroidal anti-inflammatory drug. Pharmaceutical Resonance. 2021; 3 (2); 80-92.
17.    Dr. Srinivas P, Sreeja K. Formulation and evaluation of voriconazole loaded nanosponges for oral and topical delivery. International Journal of Drug Development and Research. 2013; 5 (1): 55-69.
18.    Ms. Shaikh AN, Pawar AY. Formulation and Evaluation Nanosponges loaded hydrogel of Luliconazole. International Journal of Scientific Development and Research. 2020; 5 (8): 215-227.
19.    Harsha G, Naseeb Basha Shaik, PK Lakshmi and Latha K. Formulation and Evaluation of Sertaconazole nitrate loaded Nanosponges for Topical application. Research Journal of Pharmacy and Technology. 2021; 14 (2). 895-902. 10.5958/0974-360X.2021.00159.1
20.    Jessy Shaji, Twinkle Haresh Vaswani. Effect of Benzydamine Hydrochloride loaded Nanosponge formulations against mouth ulcers in Albino Wistar Rats. Research Journal of Pharmacy and Technology. 2021; 14 (2). 986-990. 10.5958/0974-360X.2021.00176.1
21.    Solunke R.S, Borge U.R, Murthy K, Deshmukh M.T, Shete R.V. Formulation and evaluation of gliclazide nanosponges. International journal of applied pharmaceutics. 2019; 11 (6); 181-189. https://doi.org/10.22159/ijap.2019v11i6.35006
22.    Mendes C, Meirelles GC, Barp CG, Assreuy J, Silva MA, Ponchel G. Cyclodextrin based nanosponge of norfloxacin: Intestinal permeation enhancement and improved antibacterial activity. Carbohydrate polymers 2018; 195; 586-592. 10.1016/j.carbpol.2018.05.011.
23.    Salunke A, Upmanyu N. Formulation, development and evaluation of Budesonide oral nanosponges using DOE approach: in-vivo evidences. Advanced Pharmaceutical Bulletin. 2021; 11(2), 286-294. https://doi.org/10.34172/apb.2021.041
24.    Dubey P, Sharma HK, Shah S, Tyagi CK, Chandekar AR, Jadon RS. Formulations and evaluation of Cyclodextrin complexed Cefadroxil loaded nanosponges. International Journal of Drug Delivery 2017; 9: 84-100.
25.    Swaminathan S, Pastero L, Serpe L, Trotta F, Vavia P, Aquilano D, Trotta M, Zara G, Cavalli R. Cyclodextrin-based nanosponges encapsulating camptothecin: physicochemical characterization, stability and cytotoxicity. European journal of pharmaceutics and biopharmaceutics. 2010; 74(2):193-201. http://dx.doi.org/10.1016/j.ejpb.2009.11.003
26.    Ansari KA, Vavia PR, Trotta F, Cavalli R. Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterisation, stability, cytotoxicity and permeation study. AAPS PharmSciTech 2011; 12: 279–286. https://doi.org/10.1208/s12249-011-9584-3.
27.    Omar SM, Ibrahim F, Ismail A. Formulation and evaluation of cyclodextrin-based nanosponges of griseofulvin as pediatric oral liquid dosage form for enhancing bioavailability and masking bitter taste. Saudi Pharmaceutical Journal. 2020; 28(3). 349-361. https://doi.org/10.1016/j.jsps.2020.01.016
28.    K. Vijaya Sri, Guda Santoshini, D. Ravi sankar, K. Niharika. Formulation and Evaluation of Rutin Loaded Nanosponges. Asian Journal of Research in Pharmaceutical Sciences. 2018; 8 (1): 21-24. https://doi.org/10.5958/2231-5659.2018.00005.X
29.    Shweta S. Gedam, Ganesh D. Basarkar. Formulation, Design and In vitro Characterization of Clopidogrel Bisulphate Nanosponge Tablets for Oral Administration. Research Journal of Pharmacy and Technology. 2021; 14 (4): 2069-5. https://doi.org/10.52711/0974-360X.2021.00367
30.    Penjuri SC, Ravouru N, Damineni S, Bns S, Poreddy SR. Formulation and evaluation of lansoprazole loaded Nanosponges. Turk J Pharm Sci. 2016; 13(3): 304-310. DOI: 10.4274/tjps.2016.04.
31.    Devi AB, Sunitha J, Haritha K, Vivek R, Ravali A, Sharma JV. Formulation and development of Losartan nanosponge capsules. Asian Journal of Research in Biological and Pharmaceutical Sciences. 2020; 8 (1):24-38. https://doi.org/10.36673/AJRBPS.2020.v08.i01.A05
32.    Ghurghure SM, Surwase P. (2019). Fabrication and Evaluation of Simvastatin Nanosponges for oral delivery.Indo American Journal of Pharmaceutical Research. 2019; 6 (2): 496-503. https://doi.org/10.5281/zenodo.2659295
33.    Pandya KD, Shah NV, Gohil DY, Seth AK, Aundhia CJ, Patel SS. Development of Risedronate Sodium-loaded Nanosponges by Experimental Design: Optimization and in vitro Characterization. Indian Journal of Pharmaceutical Sciences. 2019; 81(2): 309-316. 10.36468/pharmaceutical-sciences.512
34.    Yadav RP, Sheeba F.R. Nanosponges-Overview. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13 (2): 127-3. https://doi.org/10.52711/0975-4377.2021.00023
35.    Sadashivam J, Sugumaran A, Narayanaswamy D. Nanosponges: A Potential Drug Delivery Approach. Research Journal of Pharmacy and Technology. 2020; 13 (7): 3442-3448. https://doi.org/10.5958/0974-360X.2020.00611.3
36.    Praveen K, Balamurugan K. Targeted Drug Delivery through Nanosponges and its Approach. Research Journal of Pharmacy and Technology. 2020; 13 (7): 3524-3529. https://doi.org/10.5958/0974-360X.2020.00624.1
37.    Prabhu PP, Mehta CH, Nayak UY. Nanosponges- Revolutionary Approach: A Review. Research Journal of Pharmacy and Technology. 2020; 13 (7): 3536-3544. https://doi.org/10.5958/0974-360X.2020.00626.5
38.    Jeganath NS, Khilifa Fathelrahman Khalifa Abdelmagid. A Reviewc on Nanosponges- a Promising Novel Drug delivery System. Research Journal of Pharmacy and Technology. 2021; 14 (1): 501-505.
39.    Farsana P, Sivakumar R, Haribabu Y. Hydrogel based nanosponges drug delivery for topical applications – A updated review. Research Journal of Pharmacy and Technology. 2021; 14 (1): 527-530.
40.    Upadhye SS, Balkundhi S, Ghorpade VS, Ambavade SD, Abhang SV, Mulla SI, Patil PA.Nanosponges: An Innovative Approach for Targeted Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14 (3): 1797-1804.

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