Author(s): Aarti Bhati, Sanjeev Kumar, Renu Chaudhary, Sarvesh Kumar, Alimuddin Saifi

Email(s): joinbhati.aarti@gmail.com , sanjeevsaini640@gmail.com , renuu.taliyan@gmail.com , sarveshlohan@gmail.com , asherblresearch@gmail.com

DOI: 10.52711/2231-5713.2022.00032   

Address: Aarti Bhati1, Sanjeev Kumar2, Renu Chaudhary1, Sarvesh Kumar3, Alimuddin Saifi1
1Mahaveer College of Pharmacy, Meerut, Uttar Pradesh, India.
2MIT Institute of Technology, Meerut, Uttar Pradesh, India.
3H.N.B.G.U. (A Central University) Srinagar Garhwal, Uttarakhand, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 3,     Year - 2022


ABSTRACT:
A solid lipid Microparticle reaches to the target site at controlled rate and show controlled release for better therapeutic result. This drug delivery system are prepare to obtained prolonged sustained or controlled drug delivery, to improves bioavailability, to enhance stability and to reduce toxic effects follows with target drug at specific site. The solid lipid micro particles of curcumin were prepared in a view to achieve high permeability of curcumin in brain through blood-brain-barrier. The solid lipid microspheres are prepared by hot melts microencapsulation technique was used to formulate solid lipid microspheres. Twelve formulations were prepared by varying concentration of surfactants (span 20, span 60, span 80 and Tween 80). The developed formulation were subjected to various parameter such as the particle size, % entrapment efficiency, production yield, % cumulative release, percentage yield and drug loading. Based upon highest entrapment efficiency, drug release and % cumulative release the F3 formulation was considered as the best formulation. The prepared microsphere were subjected to different evaluation parameter such as melting point, thin layer chromatography, solubility, FTIR, compatibility study and In-vitro drug release. The developed formulation shows spherical and smooth surface. The % drug release of F3 formulation was found to be 86.23% after 12 hr.


Cite this article:
Aarti Bhati, Sanjeev Kumar, Renu Chaudhary, Sarvesh Kumar, Alimuddin Saifi. Design and Evaluation of Solid Lipid Microparticles of Curcumin for the Treatment of Alzheimer’s Disease. Asian Journal of Pharmacy and Technology. 2022; 12(3):193-1. doi: 10.52711/2231-5713.2022.00032

Cite(Electronic):
Aarti Bhati, Sanjeev Kumar, Renu Chaudhary, Sarvesh Kumar, Alimuddin Saifi. Design and Evaluation of Solid Lipid Microparticles of Curcumin for the Treatment of Alzheimer’s Disease. Asian Journal of Pharmacy and Technology. 2022; 12(3):193-1. doi: 10.52711/2231-5713.2022.00032   Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-3-1


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