Author(s): Komal Chandrakant Jadhav, Sourabh Sukumar Hegaje, Sadhana Uttam Jadhav, Rupesh Sopanrao Vaidhya, Mayuresh Ramesh Redkar

Email(s): mayuresh.redkar253@gmail.com

DOI: 10.52711/2231-5713.2022.00050   

Address: Komal Chandrakant Jadhav1, Sourabh Sukumar Hegaje2, Sadhana Uttam Jadhav, Rupesh Sopanrao Vaidhya3, Mayuresh Ramesh Redkar4*
1Annasaheb Dange College of Pharmacy, Ashta.
2Tatyasaheb Kore College of Pharmacy, Warananagar.
3Alard College of Pharmacy, Pune.
4Assistant Professor, Department of Pharmaceutics, Yashwantrao Bhonsale College of Pharmacy, Sawantwadi.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2022


ABSTRACT:
Solid dispersion is one of the method, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersion based on the concept that the drug is dispersed in an inert water- soluble carrier at solid state. Several water-soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and HPMC, cyclodextrin, polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. In the current research work, the solid dispersion technique can be successfully used for the improvement of dissolution of piperine and sulfamethaoxazole. In this regards, solid dispersions of these drugs were prepared by using HPMC E 100 and 2-Hydroxyproplyl beta cyclodextrin as a carrier in 1:1 ratio by solvent evaporation method. The saturation solubility and in-vitro dissolution studies of prepared solid dispersions were examined against pure piperine and sulfamethaoxazole. Faster dissolution was exhibited by piperine-2 hydroxypropyl beta cyclodextrin solid dispersion containing 1:1 ratio.


Cite this article:
Komal Chandrakant Jadhav, Sourabh Sukumar Hegaje, Sadhana Uttam Jadhav, Rupesh Sopanrao Vaidhya, Mayuresh Ramesh Redkar. Formulation and Evaluation of Solid Dispersion of Poorly Soluble Drugs. Asian Journal of Pharmacy and Technology; 12(4):309-2. doi: 10.52711/2231-5713.2022.00050

Cite(Electronic):
Komal Chandrakant Jadhav, Sourabh Sukumar Hegaje, Sadhana Uttam Jadhav, Rupesh Sopanrao Vaidhya, Mayuresh Ramesh Redkar. Formulation and Evaluation of Solid Dispersion of Poorly Soluble Drugs. Asian Journal of Pharmacy and Technology; 12(4):309-2. doi: 10.52711/2231-5713.2022.00050   Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-4-5


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DOI: 10.5958/2231–5713 


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