ABSTRACT:
Inflammatory diseases are still one of the most important heath-problems in the world. Most of anti-inflammatory drugs such as non–steroidal anti-inflammatory drugs (NSAIDS) have number of adverse effects hence there are a need to develop safe and new anti-inflammatory formulation with minimum side effects. Present study focused on investigating and comparing anti-inflammatory potential of hydroalcoholic extracts of Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris and their combinations. Inhibition of heat induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The combination ratio of hydroalcoholic extracts of Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris (2:5:3) showed the most significant membrane stabilizing action on HRBC membrane as compare tohydroalcoholic extracts of individual drugs and theirother combinations. The present study revealed that the proper combination of Tinospora cordifolia, Boerhavia diffusa, Tribulus terrestris gives more effective anti-inflammatory activity than any of the individual drug.
Cite this article:
Mital N. Manvar. In-Vitro Anti-inflammatory Activity of Traditionally reported Poly Herbal Combination. Asian Journal of Pharmacy and Technology. 2023; 13(1):1-3. doi: 10.52711/2231-5713.2023.00001
Cite(Electronic):
Mital N. Manvar. In-Vitro Anti-inflammatory Activity of Traditionally reported Poly Herbal Combination. Asian Journal of Pharmacy and Technology. 2023; 13(1):1-3. doi: 10.52711/2231-5713.2023.00001 Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-1-1
REFERENCES:
1. Thakur Malika C. Jade to Jadibuty: A Book of Herbal Cure and Medicine. Navbharat Sahitya Mandir, Bombay, 282.
2. Chopra RN, Nayar SL and Chopra IC. Glossary of Indian medicinal plants, Calcutta, New Delhi. 1956:32.
3. Durmowicz AG and Stenmak KR. Mechanisms of structural remodeling in chronic pulmonary, Hypertension. Pediatr Rev. 1999; 20:91-101
4. Arif T, Bhosale JD, Kumar N, Mandal TK, Bendre RS, Lavekar GS and Dabur R. Natural Products-antifungal agents derived from plants. Journal of Asian Natural Products Research. 2009;7:621-638.
5. Joshi V., Joshi RP. Some plants used in Ayurvedic& Homoeopathic Medicine. Journal of Pharmacognosy & Phytochemistry. 2013,2: 269-75.
6. The Wealth of India, Raw Materials; Publication & Information Directorate, Council of Scientific & Industrial Research: New Delhi 1982; 10: 252.
7. Conrad J, Dinchev D, Klaiber I, Mika S, Kostova I, Kraus W. A novel furostanolsaponin from Tribulusterrestris of Bulgarian origin. Fitoterapia. 2004; 75:117-122.
8. Zhu, W., Du, Y., Meng, H. et al. Chemistry Central Journal. A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestri. 2017; 11: 60.
9. Arawwawalaa LDAM, Arambewelaa LSR, Ratnasooriya WD. Alpiniacalcarata Roscoe: A potent antiinflammatory agent. Journal of Ethnopharmacology 2012; 139:889–92.
10. Sadique J, Al-Rqodah WA, Baghhath MF, El-Ginay RR. Fitoterapia (Italy) 1989; 60(6): 525-32.
11. Oyedapoo O, Famurewa AJ, Int J Pharmacol 1995; 33(1): 65-9.
12. Chou CT. The anti inflammatory effect of Tripterygiumwilfordihook on adjuvant induced paw edema in rats and inflammatory mediators release. Phytother Res 1997; 11:152-4.