Author(s):
D Nirmala, K Sai Bhavani, M Sudhakar
Email(s):
dasarinirmala1980@gmail.com
DOI:
10.52711/2231-5713.2023.00033 
Address:
D Nirmala1*,K Sai Bhavani1, M Sudhakar2
1,2Department of Pharmaceutics, Malla Reddy College of Pharmacy Affiliated to Osmania University. Telangana, India.
3Associate Professor, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad 500100.
*Corresponding Author
Published In:
Volume - 13,
Issue - 3,
Year - 2023
ABSTRACT:
Present study was aimed to formulation and evaluation of Simvastatin nanoparticles. Simvastatin nanoparticles were prepared by High pressure homogenization method by using lipid (Glyceryl Monostearate), polymer (Chitosan, Sodium Alginate) and surfactant (Tween 80) in the formulation. The prepared nanoparticles were evaluated for particle size, zetapotential, entrapment efficiency, drug excipients compatability studies by FTIR, scanning electron microscopy and invitro release studies. Among all the formulations, The formulation F8 showed particle size 97.47nm, PDI as 0.333, zeta potential -30.60mV and % Entrapment efficiency 85.69%, FTIR studies shown that drug was compatable with excipients, Scanning electron microscopy results shown that particles in the formulation shows moderately spherical in shape and drug release maximum 97.28%. So, formulations F8 showed better sustain the drug release for 12hrs period of time as compared to other prepared formulations, hence drug release kinetics was applied for F8 formulation. Drug release kinetic studies it showed that optimized formulation F8 showed zero order with non-fickian mechanism.
Cite this article:
D Nirmala, K Sai Bhavani, M Sudhakar. Formulation and Evaluation of Simvastatin Nanoparticles. Asian Journal of Pharmacy and Technology. 2023; 13(3):183-8. doi: 10.52711/2231-5713.2023.00033
Cite(Electronic):
D Nirmala, K Sai Bhavani, M Sudhakar. Formulation and Evaluation of Simvastatin Nanoparticles. Asian Journal of Pharmacy and Technology. 2023; 13(3):183-8. doi: 10.52711/2231-5713.2023.00033 Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-3-6
REFERENCES:
1. Shiva kumar yellanki, Sai manoj A and Mangilal T (2021) Preparation and in vitro evaluation of metoprolol-loaded bovine serum albumin nanoparticle. Asian journal Pharm Clin Res, 14(1), 213-217
2. Monowar Hussaini et al. (2020) Formulation and Evaluation of Ethambutol Polymeric Nanoparticles. Int J App Pharm, 12(4), 207-217.
3. Alam Zeba et al. (2019) Simvastatin- loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model. International Journal of Pharmaceutics, 560, 136–143.
4. Vipan kumar kamboj and Prabhajar kumar verma (2018) Preparation and characterization of metformin loaded steric acid coupled F127 Nanoparticles. Asian J Phar Clin Res, 11(8), .212-2
5. Surendranath Betala1 et al. (2018) Formulation and evaluation of polymeric nanoparticles of an anti-hypertensive drug labetalol. Journal of Drug Delivery and Therapeutics, 8(6-s), 187-191.
6. Jin Sun a, d et al. (2017) The studies of PLGA nanoparticles loading atorvastatin calcium for oral administration in vitro and in vivo. asian journal of pharmaceutical sciences, 12, 285-291
7. N. Selvasudha et al. (2017) Optimization of formulation parameters and characterization of simvastatin loaded chitosan nanoparticles. Int.Jou.Adv.Res, 5(2), 2386-2400.
8. Shanmuganathan Seetharaman1 et al. (2016) Preparation and Evaluation of Cefixime Nanoparticles Prepared Using Fenugreek Seed Mucilage and Chitosan as Natural Polymers. IJPCR, 8(3)
9. K. Masilamanib et al. (2015) Development and Evaluation of Chitosan Based Polymeric Nanoparticles of an Antiulcer Drug Lansoprazole. Journal of Applied Pharmaceutical Science, 5 (04), 020-025
10. Vijaya Bhaskar N et al. (2015) Formulation and characterisation of Simvastatin nanoparticles loaded transdermal patch. Journal of Chemical and Pharmaceutical Research, 7(7), 1084-1093
11. P.Swathi et al. (2014) Formulation of ibuprofen loaded ethyl cellulose nanoparticles by nanoprecipitation technique. Asian.Jou.Pharm.Clin.Res, 7(3), 44-48
12. Tiruwa R (2015) A review on nanoparticles preparation and evaluation parameter. Indian Journal of Pharmaceutical and Biological Research. 4(2).27-31.
13. Pal SL, Jana U and manna Pk (2011) Nanoparticles: An overview of preparation and characterization. Journal of Applied Pharmaceutical Science. 1(6), 228-259.
14. Khosla G, Goswami L and kothiyal P (2012) Nanoparticles: A Novelistic Approach for CNS disorders. Journal of Advanced Pharmaceutical Sciences, 2(2), 220-259.
15. Lam P-L et al. (2017) Recent advances in green nanoparticulate systems for drug delivery: efficient delivery and safety concern. Nanomedicine. 12, 357–85.
16. Jahangirian H et al. (2017) A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine. Int J Nanomed. 12, 2957.
17. Siddiqui AA, Iram F, Siddiqui S and Sahu K (2014) Role of natural products in drug discovery process. Int J Drug Dev Res. 6(2), 172–204