Author(s): D Nirmala, K Sai Bhavani, M Sudhakar

Email(s): dasarinirmala1980@gmail.com

DOI: 10.52711/2231-5713.2023.00033   

Address: D Nirmala1*,K Sai Bhavani1, M Sudhakar2
1,2Department of Pharmaceutics, Malla Reddy College of Pharmacy Affiliated to Osmania University. Telangana, India.
3Associate Professor, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad 500100.
*Corresponding Author

Published In:   Volume - 13,      Issue - 3,     Year - 2023


ABSTRACT:
Present study was aimed to formulation and evaluation of Simvastatin nanoparticles. Simvastatin nanoparticles were prepared by High pressure homogenization method by using lipid (Glyceryl Monostearate), polymer (Chitosan, Sodium Alginate) and surfactant (Tween 80) in the formulation. The prepared nanoparticles were evaluated for particle size, zetapotential, entrapment efficiency, drug excipients compatability studies by FTIR, scanning electron microscopy and invitro release studies. Among all the formulations, The formulation F8 showed particle size 97.47nm, PDI as 0.333, zeta potential -30.60mV and % Entrapment efficiency 85.69%, FTIR studies shown that drug was compatable with excipients, Scanning electron microscopy results shown that particles in the formulation shows moderately spherical in shape and drug release maximum 97.28%. So, formulations F8 showed better sustain the drug release for 12hrs period of time as compared to other prepared formulations, hence drug release kinetics was applied for F8 formulation. Drug release kinetic studies it showed that optimized formulation F8 showed zero order with non-fickian mechanism.


Cite this article:
D Nirmala, K Sai Bhavani, M Sudhakar. Formulation and Evaluation of Simvastatin Nanoparticles. Asian Journal of Pharmacy and Technology. 2023; 13(3):183-8. doi: 10.52711/2231-5713.2023.00033

Cite(Electronic):
D Nirmala, K Sai Bhavani, M Sudhakar. Formulation and Evaluation of Simvastatin Nanoparticles. Asian Journal of Pharmacy and Technology. 2023; 13(3):183-8. doi: 10.52711/2231-5713.2023.00033   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-3-6


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