Author(s):
Tanmay Jit, Saptarshi Mukherjee, Sailee Chowdhury, Gouranga Nandi, Jashabir Chakraborty, Dibyendu Shil, Saumendu Deb Roy
Email(s):
tanmayjit.mgcop@gmail.com
DOI:
10.52711/2231-5713.2024.00063 
Address:
Tanmay Jit1, Saptarshi Mukherjee2, Sailee Chowdhury3, Gouranga Nandi4, Jashabir Chakraborty5, Dibyendu Shil6, Saumendu Deb Roy7
1Assistant Professor, Department of Pharmaceutics, Mata Gujri College of Pharmacy, Mata Gujri University Kishanganj, Bihar - 855107, India.
2Assistant Professor, Divine College of Pharmacy, Near Jamapur Bazar, Pathardei, Ziradei, Bihar-841245, India.
3Professor, Department of Pharmaceutical Chemistry, BCDA College of Pharmacy and Technology, Hridaypur, Kolkata, 700127, India.
4Assistant Professor, HOD of Department of Pharmaceutical Technology University of North Bengal, Raja Rammohun, Darjeeling, 734013, India.
5Professor, Department of Pharmacology, Mata Gujri College of Pharmacy, Mata Gujri University, Kishanganj, Bihar - 855107, India.
6Professor, Department of Pharmacognosy, Mata Gujri College of Pharmacy, Mata Gujri University, Kishanganj, Bihar - 855107, India.
7Professor Principal, Department of Pharmacognosy, Mata Gujri College of Pharma
Published In:
Volume - 14,
Issue - 4,
Year - 2024
ABSTRACT:
Microspheres are free-flowing, spherical particles made of synthetic polymers or proteins with an average size between 1 and 50 microns. A controlled drug delivery system that improves a medicine's therapeutic effectiveness can help solve some of the issues. One such method is the use of microspheres as medication carriers. Drugs are delivered specifically to the target place and their concentration is maintained there without side effects. It will take centre stage in cutting-edge medication delivery. Using microspheres, medications may be directed to certain bodily locations. A drug's degree of targeting can be determined by localizing it to a particular section of the body, such as the lungs, a certain cell type, such as Kupffer cells, or even intracellular structures, such as lysosomes or cell nuclei. The microspheres' medicinal effect is determined by the speed at which the medication releases from them. The chemical makeup of the polymer and the medication, the polymer's resistance to degradation, the microspheres' surface area and porosity, and their combined interactions all influence release. Depending on the microencapsulation technique used, the interior structure of the microspheres might change. Diffusion of the drug through a polymeric excipient and diffusion of the drug contained inside the pores of the polymeric microspheres allow for controlled drug release from the microspheres.
Cite this article:
Tanmay Jit, Saptarshi Mukherjee, Sailee Chowdhury, Gouranga Nandi, Jashabir Chakraborty, Dibyendu Shil, Saumendu Deb Roy. Microsphere in Novel Drug Delivery System - A Descriptive Review. Asian Journal of Pharmacy and Technology. 2024; 14(4):399-6. doi: 10.52711/2231-5713.2024.00063
Cite(Electronic):
Tanmay Jit, Saptarshi Mukherjee, Sailee Chowdhury, Gouranga Nandi, Jashabir Chakraborty, Dibyendu Shil, Saumendu Deb Roy. Microsphere in Novel Drug Delivery System - A Descriptive Review. Asian Journal of Pharmacy and Technology. 2024; 14(4):399-6. doi: 10.52711/2231-5713.2024.00063 Available on: https://ajptonline.com/AbstractView.aspx?PID=2024-14-4-16
REFERENCES:
1. Reddy BV, Krishnaveni K. Formulation and evaluation of efavirenz microspheres. Der Pharmacia Letters. 2015; 7(6): 1-9.
2. Sarode SM, Mittal M, Magar RM, Shelke AD, Shrivastava B, Vidyasagar G. Formulation and evaluation of floating microspheres of Glipizide. J Chem Pharm Res. 2011; 3(3): 775-783.
3. Miléna Lengyel, Review Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery, Scientia. Pharmaceutica. 2019; 87- 20.
4. Badilli U, Sen T, Tarimci N. Microparticulate based topical delivery system of Clobetasol Propionate. AAPS PharmSciTech 2011; 12: 949-57.
5. Basarkar G, Shirsath G, Patil S. Development of microspheres containing Diclofenacdiethylamine as sustained release topical formulation. Bull Pharm Res. 2013; 3: 14-22.
6. Labouta H, El-Khordagui L. Polymethacrylate microparticles gel for topical drug delivery. Pharm Res. 2010; 27: 2106-18.
7. S. Y. RAI, et. al., Development and Evaluation of Microsphere based Topical Formulation using Design of Experiments, Indian Journal of Pharmaceutical Sciences. 2016; 78(2): 182-192
8. Tarun Virmani, et. al., Pharmaceutical Application of Microspheres: An Approach for The Treatment of Various Diseases, International Journal of Pharmaceutical Sciences and Research. 2017; 7: 3252-3260.
9. Divya thakur m. pharm, presentation on introduction, advantage, disadvantage, and ideal properties of microsphere, slideshare. Published on Oct 17, 2016.
10. Mukund J. Y, Kantilal B. R, Sudhakar R. N, Floating microspheres: A review, Braz. J. Pharm. 2012; 48(1): 17-30.
11. Kawatra M, Jain U, Ramana J. Recent advances in floating microspheres as gastro-retentive drug delivery system: A review, IJRAPR. 2012; 2(3): 5-23.
12. Singh C, Purohit S, Singh M, Pandey B.L. Design and evaluation of microspheres: A Review. JDDR. 2013; 2(2): 1827.
13. Ramteke K.H, Jadhav V.B, Dhole S.N. Microspheres: As carrieres used for novel drug delivery system. IOSRPHR. 2012; 2(4): 44-48.
14. Dupinder K, Seema S, Gurpreet S, Rana A.C, Biodegradable microspheres: A review. IRJP. 2012; 3(12): 23-27.
15. Saralidze K, Koole L.H, Knetsch M.L.W. Polymeric microspheres for medical applications. Materials. 2010; 3: 37-64.
16. Gogu P.K. Preparation & invivo/ invitro characterisation of Spray Dried Microspheres Formulation Encapsulating 4- Chlorocurcumin. Indian Journal of Pharmaceutical Sciences. 2010; 72: 346-352.
17. Dadhichi K.T. M.Pharm Semester, Formulation and Evaluation of Microspheres, Department of Pharmaceutical Technology Arihant College of Pharmacy Gujarat Technical University.
18. Katarpia S, Middha A, Sandhu P, Ajay B, Bhawana K. Review article on microsphere, Seth G. L. Bihani S.D. College of Technical Education, Institute of Pharmaceutical Sciences and Drug Research. 2011.
19. Singh C, Purohit S, Singh M, Pandey B.L. Design and evaluation of microspheres: A Review, JDDR. 2013; 2(2): 18- 27.
20. Sahil K, Akanksha M, Premjeet S, Bilandi A, Kapoor B. Microsphere: A review. Int. J. Res. Pharm. Chem. 2011; 1(11): 84-98.
21. Pavan K. B, Chandiran I.S, Bhavya B, Sindhuri M. Microparticulate drug delivery system: A Review. Indian Journal of Pharmaceutical Science and Research. 2011; 1(1): 19- 37.
22. Dhakar R.C, Maurya S.D, Sagar B.P.S, Bhagat S, Prajapati S.K, Jain C.P. Variables influencing the drug entrapment efficiency of microspheres: A pharmaceutical review. Der Pharmacia Lettre. 2010; 2(5): 102-116.
23. Parmar H, Bakliwal S, Gujarathi N, Rane B, Pawar S. Different methods of formulation and evaluation of mucoadhesive microsphere. International Journal of Applied Biology and Pharmaceutical Technology. 2010; 1(3): 1157-67.
24. Gogu P.K. Preparation & invivo characterization of spray dried Microspheres formulation Encapsulating 4-chlorocurcumin. Indian Journal of Pharmaceutical Sciences. 2010; 72: 346-352.
25. Li Y P, Machida T Y, Sannan T, Nagai T. Preparation of chitosan microspheres containing fluorouracil using the ‘dryin-oil’ method and its release characteristics. STP Pharm. Sci. 1991; 1: 363–368.
26. Kyotani S, Nishioka Y, Okamura M, Tanaka T, Miyazaki M, Ohnishi S, Yamamoto Y, Ito K, Ogiso T, Tanada S. A study of embolizing materials for chemo-embolization therapy of hepatocellular carcinoma antitumor effect of cis diamminedichloroplatinum (II) albumin microspheres, containing chitin and treated with chitosan on rabbits with VX2 hepatic tumors. Chem. Pharm. Bull. 1990; 40: 2814– 2816.
27. Sinha V.R, Bansal K, Kaushik R, Kumria R, Trehan A. Polycaprolactone microspheres and nanospheres. International Journal of Pharmaceutics. 2004; 278: 1–23.
28. Jameela S R, Jayakrishnan A. Glutaraldehyde crosslinked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle. Biomaterials. 1995; 16: 769–775.
29. Hassan E.E, Parish R.C, Gallo J.M. Optimized formulation of magnetic chitosan microspheres containing the anticancer agent oxantrazole. Pharm. Res. 1992; 9: 390– 397
30. Shah S, Qaqish R, Patel V, Amiji M, Evaluation of the factors influencing stomach-specific delivery of antibacterial agents for Helicobacter pylori infection. J. Pharm. Pharmacol. 1999; 51: 667–672.
31. Parul T, Varma A L M, Garud N. Preparation and characterization of aceclofenac microspheres, Asianpharmainfo. 2010.
32. Shiraishi S, Imai T, Otagiri M. Controlled release of indomethacin by chitosan–polyelectrolyte complex: optimization and in vivo/in vitro evaluation J. Control Rel. 1993; 25:217–225.
33. Murata Y, Miyamoto E, Kawashima S, Additive effect of chondroitin sulfate and chitosan on drug release from calciuminduced alginate gel beads. J. Control Rel. 1996; 38: 101–108.
34. Rahul N, B Haritha, Reddy C.K, Ashok K, Kumar K.J. Application of chitosan microspheres as drug carriers J.Pharm. Sci. & Res. 2009; 1: 1-12.
35. Lim S T, Martin G P, Berry D J, Brown M B, Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan J Control Rel. 2000; 66: 281–292
36. Berthold A, Cremer K, Kreuter J, Influence of crosslinking on the acid stability and physicochemical properties of chitosan microspheres. STP Pharm. Sci. 1996; 6: 358–364.
37. Alagusundaram M, Madhu S C C, Umashankari K, Attuluri V B, Lavanya C, Ramkanth S, Microspheres as a Novel Drug Delivery System, Chemtech. 2009; 13; 526-534,
38. Bodmeier R, Wang J, Bhagwatwar H J, Microencaps. J Pharm.Sci. 1992; 9: 99–107.
39. Yi M.K, Sun K, Mi R.P, Young J.P, Seung H.B, Hyun W.S. The present invention relates to a continuous process for preparing microspheres and microspheres prepared thereby, and in particular, a process for preparing microspheres, February 5, (2019), Patent no.10195149.
40. Paul M.W, William D.H, George G W. Glass composites for tissue augmentation, biomedical and cosmetic applications, February 12, (2019), Patent no. 10201633.
41. Franciscus gerardus henricus duijnhoven van, franciscus wilhemus maria gelissen, Microsphere comprising a polymer core, a shell and an absorber, June 30,(2008), Patent no.9050843.
42. Franciscus Wilhelmus Maria Gelissen, Franciscus Gerardus Henricus Van Duijnhoven, The present invention relates to microspheres and to their use, preferably as laser absorbing additive, and to a process for their production, October 16,(2013), Patent No. 9944778.
43. Terry L. Turner, Stuart S. Howards, Intraorgan injection of biologically active compounds contained in slow-release microcapsules or microspheres, May 1, (1989), Patent No. 5017378
44. Cassidy, J.P.; Landcert, N.M.and Quardos, E. Controlled buccal delivery of buprenorphine. J. control. Rel. 1993; 25: 21-29.
45. Dortune, B.; Ozer, L.and Vyanik, N. Development and invitro Evaluation of buccoadhesive pindodlo tablet formulation. Drug Dev. Ind. Pharm. 1998; 24(3): 281-288.
46. Guo, J.H. Bioadhesive polymer buccal patches for buprenorphine-controlled delivery: formulation in vitro adhesive and release properties. Drug Dev.Ind. Pharm. 1994; 20(3): 315- 325.
47. Nagai, T.; Machida, Y.; Suzuki Y.and Ikura, H. Method and preparation for administration to the mucosa and preparation for administration to the mucosa of the oral or nasal cavity. US patent No.4226848, 1980.
48. Chein, Y.W.and Novir, M. Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity. US patent No.5578315, 1996.
49. Fabregas, J.L.and Garcia, N. Invitro studies on buccoadhesive tablet formulations of hydro cortisone hemisuccinate. Drug Dev. Ind. Pharm., 1995; 21(14): 1689-1696.
50. Rathbone, M.J.; Purve, R.: Ghazati, F.A.and HO, P.C. In vivo techniques for studying the oral mucosa absorption characteristics of drugs in animals and humans. In Rathbone, M.J. (ed.), oral mucosal delivery systems, Marcel Dekker Inc.Newyork. 1996; 3(2): 121-156.
51. Lu, M.F.and Hui, H.W. Delivery of rennin inhibitors through mouth mucosa. Drug Dev. Ind. Pharm., 1996; 22(11): 1167-1171.
52. Yukimatsu, K.; Nozaki, Y.; Kakumoto, M.and Ohta, M. Development of a transmucosal controlled release device for systemic delivery of antianginal drugs Dev. Ind. Pharm, 1994; 20(4): 503-534.
53. Hussain, M.A; Aungst, B.J.; Kearney A. and Shefter, E. Buccal and oral bioavailability of naloxone and naltrexone in rats. Int, J. Pharm., 36, 1987,127.
54. Oh, C.K. and Ritschel, W.A. Biopharmaceutical aspects of buccal absorption of insulin rabbits I. Effects of dose, size, Ph & sorption enhancers: in vivo in vitro correlation. Pharm. Res. 1999a; 5(5): 91-100.
55. Oh, C.K. and Ritschel, W.A. Biopharmaceutical aspects of buccal absorption of insulin in rabbits II. Absorption characteristics of insulin through the buccal mucosa. Pharma. Res., 1988b; 5(5): 91- 100.
56. Kellaway, I.W. and warren, S.I. Mucoadhesive hydrogels. Proc. Intern. Symp. Control. Rel. Bioact. Mater. 18, 1991,70-73.
57. Ishida, M.: Nambu, N.and Nagai, T. Highly viscous gel ointment containing carbopol for application to the oral mucosa. Chem Pharm Bull. 1983a; 31: 4561.
58. Ishida, M.; Nambu, N. and Nagai, T. Ointment type oral mucosal dosage form of carbopol containing prednisolone for the treatment of aphtha. Chem. Pharm. Bull. 1983b; 31: 1010.
59. Hoogstrate, A.J., Verhoef, J.C.; Tuk., B.; Pijpers, A.; Vercheijden, J.H.M.; Jungiger, H.E. and Bodde, H.C. Invivo buccal delivery of fluorescein iso thiocyanate– dextran 4400 with glycodeoxy cholate as an absorption enhacer in pigs. J.Pharm.Sci., 1996b; 85(5): 457-460.
60. Burnside, B.A; Keith, A.P. and snipes, W. Micro porous hollow fibers as a peptide delivery system via the buccal activity. proceed inter symp control Rel Bioact mater. 1989; 16: 94.
61. N.K. Jain. Controlled and Novel Drug Delivery, 4 Edition, 236-237, 21.
62. N. Venkateswarlu. Biopharmaceutics and Kinetics. 2004 Edition, 53, 54.
63. Widder K.J., Sanyci A.E., Ovadia H., and Paterson P.Q. Clin. Immuno. Immuno Pathol. 1979; 14: 395.
64. Funden berg H.H., Stites D.P., Caldwel J.L.and Wells J.V. In: Basic and Clinical Immunology, 2 ed., Lange Medical, Los Altosca. 1978
65. Capron A.C., Locht C. and Fracchia G.N (1994) Vaccine.12, 667; Edelman R. vaccine 11, 1361; Drews J. (1984) Immunostimulantien, Klin. Wochenscher. 62, 254; Spier K.E. (1993) Vaccine 11, 1993, 1450.
66. Nachts S. and Martin K. In: The microsponges a novel topical programmable delivery formulation, Marcel Dekker Inc., Newyork. 1990: 299.
67. Kalyan Shweta, Sharma Parmod Kumar et al. Recent Advancement in Chitosan Best Formulation And Its Pharmaceutical Application. Pelagia Research Library. 2010; 1(3): 195-210.