Toxicokinetics (TK) is ‘the generation of pharmacokinetic data, either as an integral component in the conduct of non-clinical toxicity studies or in specially designed supportive studies, to assess systemic exposure. Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals. Toxicokinetics, toxicodynamics and toxicogenomics (TK/TD/TG) methods are the potential tools in human health risk assessment.
Cite this article:
Merlin. N. J, Alfiya. A. R, Shaiju S Dharan. Toxicokinetics-A Review. Asian J. Pharm. Tech. 2018; 8 (3):182-185. doi: 10.5958/2231-5713.2018.00029.6