Author(s): Rutuja T Jadhav, Yashvardhan P Bhosale

Email(s): rutujatjadhav21@gmail.com

DOI: 10.5958/2231-5713.2021.00001.5   

Address: Rutuja T Jadhav1*, Yashvardhan P Bhosale2
1Dept of Pharmaceutical Chemistry, SND College of Pharmacy, Bhabhulgaon, Yeola.
2Dept of Quality Assurance, Mahatma Gandhi Vidyamandir’s Pharmacy College, Nashik
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2021


ABSTRACT:
Isoniazid is an organic compound. It is a first line drug used in prevention and treatment of tuberculosis also Isoniazid has an anti-depressant effect. Isonicotin hydrazine is also known as isoniazid. A process was developed for the preparation of isoniazid from citric acid via citrazinic acid 2, 6-dichloroisonicotinic acid, isonicotinic acid and ethyl isonicotinate. Yields and procedures in all steps were improved (1).


Cite this article:
Rutuja T Jadhav, Yashvardhan P Bhosale. Synthesis of Isoniazid from Citric Acid. Asian J. Pharm. Tech. 2021; 11(1):1-4. doi: 10.5958/2231-5713.2021.00001.5

Cite(Electronic):
Rutuja T Jadhav, Yashvardhan P Bhosale. Synthesis of Isoniazid from Citric Acid. Asian J. Pharm. Tech. 2021; 11(1):1-4. doi: 10.5958/2231-5713.2021.00001.5   Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-1-1


REFERENCES:

1.      Baizer MM, Dub M, Gister S, Steinberg NG. Synthesis of Isoniazid from Citric Acid. J Am Pharm Assoc (Scientific Ed) [Internet]. 1956;45(7): 478–80.

2.      Counihan HE, Abrahamson ML, O’connor MH, Dickenson J. Isoniazid in pulmonary tuberculosis. J Ir Med Assoc. 1953 Jan;32(187): 18–20.

3.      Isoniazid in pulmonary tuberculosis. Br Med J. 1952 Oct;2(4787): 764–5.

4.      Pansy FE, Koerber WL, Stander H, Donovick R. The inactivation of isoniazid by Dubos medium. Am Rev Tuberc. 1953 Aug;68(2): 284–5.

5.      van Hest R, Baars H, Kik S, van Gerven P, Trompenaars M-C, Kalisvaart N, et al. Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment. Clin Infect Dis an Off Publ Infect Dis Soc Am. 2004 Aug;39(4): 488–96.

6.      Tripathi A, Nadaf YF, Bilehal D, Nayak S, Gaonkar SL. A review on synthesis of isoniazid derivatives and their biological properties. Int J Pharm Res. 2019;11(1): 21–36.

7.      Gupta A, Kaul A, Tsolaki AG, Kishore U, Bhakta S. Mycobacterium tuberculosis: immune evasion, latency and reactivation. Immunobiology. 2012 Mar;217(3): 363–74.

8.      “The United States Pharmacopeia,” 15th rev., Mack Publishing Co., Easton, Pa., 1955, p. 367.

9.      Mayer and Nally, Monatsh., 33,400 (1912)

10.   Behrmann and Hofmann, Ber., 17, 2681(1884)

11.   U. S. pat. 2,728,773, Dec 27, 1955, M. M. Baiser to the New York Quinine and Chemical Works, Inc.

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DOI: 10.5958/2231–5713 


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