Author(s): Swapnil Suryawanshi, Jyoti Sonawane, Siddiqua Shaikh, Habeeba Shaikh


DOI: 10.5958/2231-5713.2021.00005.2   

Address: Swapnil Suryawanshi*, Jyoti Sonawane, Siddiqua Shaikh, Habeeba Shaikh
1Deparment of Pharmaceutics, SND College of Pharmacy, Babulgoan, Yeola, Maharashtra 423401.
2Department of Quality Assurance, SND College of Pharmacy, Babulgoan, Yeola, Maharashtra 423401.
3Department of Medicinal Chemistry, SND College of Pharmacy, Babulgoan, Yeola, Maharashtra 423401.
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2021

Objective: Preparation of solid dispersion of drug with different water-soluble polymers/carriers or without the addition of sodium lauryl sulphate (SLS) as surfactant Methods and Materials: The Solvent evaporation method was used for the preparation of solid dispersion. Solid dispersion was prepared in five different drugs:carrier ratios (1:1, 1:2, 1:3, 1:4 and 1:5). The different material used for formatting the piroxicam was Poiroxicam solid dispersion, microcrystalline cellulose, sodium starch glycolate, hroxyl propyl methyl cellulose, magnesium stearate, talc. The dissolution profile is done by using 0.1 N HCl (pH 1.2) (volume 900ml, temperature 37±0.05ºC). 5ml of sample at each sampling interval was withdrawn. After each sampling, sample withdrawn was replaced by same dissolution media kept in the control flask. The sample withdrawn was then immediately filtered and analyzed for sample content by UV spectrophotometer at 358nm after suitable dilutions. Stability study was done by for one month tablet samplewas analyzed for drug content & dissolution. Results and Discussion: solubility and dissolution of piroxicam could be significantly improved by solid dispersion technique. Fast dissolving tablets of piroxicam containing solid dispersion having less disintegration time, wetting time and greater drug release with required mechanical strength were prepared successfully.

Cite this article:
Swapnil Suryawanshi, Jyoti Sonawane, Siddiqua Shaikh, Habeeba Shaikh. Design Preparation and Formulation of Piroxicam Solid Dispersion. doi: 10.5958/2231-5713.2021.00005.2

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