R. G. Maskare, N. H. Indurwade, R. A. Deshmukh, P. V. Kuthe, P. M. Londhe, M. T. Deshmukh
R. G. Maskare*, N. H. Indurwade, R. A. Deshmukh, P. V. Kuthe, P. M. Londhe, M. T. Deshmukh
Manoharbhai Patel Institute of Pharmacy (B. Pharm), Kudwa, Gondia, Maharashtra. 441614.
Volume - 11,
Issue - 1,
Year - 2021
The objective of our work was to maximize the therapeutic efficacy of Atrovastatin by developing oil in water (o/w) nanoemulsion to increase its poor solubility and consequently enhance the oral bioavailability. The aim of investigation was to rectify the first-pass metabolism of Atorvastatin, using preparation of nanoemulsion as a prominent delivery system. Olive oil, surfactant (tween 80, tween 40, tween 20) and co-surfctants including polyethylene glycol was selected after solubility studies. Then pseudo-ternary phase diagram with surfactant/ co- surfactant ratio of 1:1, 2:1, 3:1 and 4:1 were constructed and spontaneous emulsification method. Titration method was used to optimize the Atorvastatin loaded nanoemulsions. The prepared nanoemulsion was characterized by globule size, refractive index, partition coefficient, viscosity, drug entrapment efficiency, in vitro drug release studies. Optimised nanoemulsion obtained was composed of olive oil (8.5 %w/w), tween 80 (11.5 %w/w) and water (80 %w/w). The results obtained showed an average globule size. The Optimized formulation showed an improvement in solubility of Atorvastatin. The use of pseudo-ternary phase diagram allows obtaining an optimal nanoemulsion with perfect stability for three months and a better solubilization capacity of Atorvastatin.
Cite this article:
R. G. Maskare, N. H. Indurwade, R. A. Deshmukh, P. V. Kuthe, P. M. Londhe, M. T. Deshmukh. Nanoemulsions: Increasing Possibilities in Oral Drug Delivery. Asian J. Pharm. Tech. 2021; 11(1):53-58. doi: 10.5958/2231-5713.2021.00009.X
R. G. Maskare, N. H. Indurwade, R. A. Deshmukh, P. V. Kuthe, P. M. Londhe, M. T. Deshmukh. Nanoemulsions: Increasing Possibilities in Oral Drug Delivery. Asian J. Pharm. Tech. 2021; 11(1):53-58. doi: 10.5958/2231-5713.2021.00009.X Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-1-9
1. Shinoda K., Kunieda, H., Encyclopedia of Emulsion Technology, Marcel Dekker, New York, 1983, pp. 337-367.
2. De Villiers, M.M; Aramwit, P.; Kwon, G.S. In: Nanotechnology in drug delivery; Biotechnology: pharmaceutical aspects. AAPS Press., 2009, Vol. 60, pp. 350-365.
3. M. Kumar, A. Misra, A. K. Babbar and A. K. Mishra “Intranasal Nanoemulsion Based Brain Targeting Drug Delivery System of Risperidone,” International Journal of Pharmaceutics, Vol. 358, 1-2, 2008, pp. 285-291. doi:10.1016/ j.ijpharm.2008.03.029.
4. S. Talegaonkar, G. Mustafa, S. Akhter & Z. I. Iqbal (2010) Design and Development of Oral Oil-in-Water Nanoemulsion Formulation Bearing Atorvastatin: In Vitro Assessment, Journal of Dispersion Science and Technology, 31:5, 690-701, DOI: 10.1080/01932690903120540
5. Chhabra, G.; Chhuttani, K.; Mishra, A.; Pathak, K. Design and development of nanoemulsion drug delivery system of amlodipine besilate for improvement of oral bioavaibility. Drug. Dev. Ind. Pharm., 2011, 37, 907-916.
6. M. Kumar, A. Misra, A. K. Babbar and A. K. Mishra “Intranasal Nanoemulsion Based Brain Targeting Drug Delivery System of Risperidone,” International Journal of Pharmaceutics, Vol. 358, 1-2, 2008, pp. 285-291. doi: 10.1016/j.ijpharm.2008.03.029.
7. T. Tadros, P. Izquierdo, J. Esquena and C. Solans, “Formation and Stability of Nanoemulsions,” Advances in Colloids and Interface Science, Vol. 108-109, 2004, pp. 303-318. doi:10.1016/j.cis.2003.10.023.
8. Leuner, C.; Dressman, J. Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm Biopharm., 2000, 50, 47-60.
9. T. P. U. Ravi and T. Padma, “Nanoemulsions for Drug Delivery through Different Routes,” Research in Biotechnology, Vol. 2, No. 3, 2011, pp. 1-13.
10. Mustafa, G.; Iqbal, Z.; Bansal, T.; Talegaonkar, S. Preparation and characterization of ultrafine oil in water nano-reservoir systems for improved oral delivery of Atorvastatin. Curr. Nanosci., 2009, 5, 428-440.
11. F. L. Primo, L. Michieloto, M. A. M. Rodrigues, P. P. Macaroff, P. C. Morais, Z. G. M. Lacava, M. V. L. B. Bently and A. C. Tedesco, “Magnetic Nanoemulsions as Drug Delivery System for Foscan: Skin Permeation and Retention in Vitro Assays for Topical Application in Photodynamic Therapy (PDT) of Skin Cancer,” Journal of Magnetism and Magnetic Materials, Vol. 311, No. 1, 2007, pp. 354-357. doi:10.1016/ j.jmmm. 2006.10.1183.
12. Kim Y H, Ghanem A H, Mahmoud H, Higuchi W I Short chain alkanols as transport enhancers for lipophilic and polar ionic permeants in hairless mouse skin mechanism of action lnt. J pharm 2001;215,57-65.
13. Kawakami, K.; Yoshikawa, T.; Hayashi, T.; Nishihara, Y.; Masuda, K. Microemulsion for the enhanced absorption of poorly soluble drug and in vivo study. J. Control. Release., 2002, 81, 75-82.
14. Lawrence, M.J.; Rees, G.D. Microemulsion-based media as novel drug delivery systems. Adv. Drug. Deliv. Rev., 2000, 45, 89-121.