Author(s): Rahul Rajge, Vishal Mahanur, Mukund Tawar

Email(s): rajgerahul88@gmail.com

DOI: Not Available

Address: Rahul Rajge, Vishal Mahanur, Mukund Tawar
Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy Amravati – 444604.
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2021


ABSTRACT:
The present work was carried out to study the probable interactions of commonly used beverages on the release characteristics of Meclizine HCl sustained release tablet dosage form. Studies were carried out to evaluate the alterations in disintegration time and in-vitro dissolution profiles of Meclizine HCl from the tablets. All the studies indicated that the time required for disintegration of Meclizine HCl tablets is more with the modified immersion media as compared with that in water. At the end of the study it was revealed that more than 82% of Meclizine HCl from tablets MF1 was released in Distilled Water and other modified dissolution media except Coffee, Aerated Cola Drink, Non-Aerated Soft Drink and hence, the tablets failed the USP acceptance criteria in water and other dissolution modified media. In Coffee, Aerated Cola Drink, Non-Aerated Soft Drink having passed the USP acceptance criteria. All the three brands of Meclizine HCl viz. MF1, MF2 and MF3 failed to comply with the USP criteria for percentage drug release within 8 h in distilled water.


Cite this article:
Rahul Rajge, Vishal Mahanur, Mukund Tawar. Effect on Drug Release profile of Meclizine Hydrochloride by using various Dissolution Media. Asian Journal of Pharmacy and Technology. 2021; 11(3):191-7.

Cite(Electronic):
Rahul Rajge, Vishal Mahanur, Mukund Tawar. Effect on Drug Release profile of Meclizine Hydrochloride by using various Dissolution Media. Asian Journal of Pharmacy and Technology. 2021; 11(3):191-7.   Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-3-1


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