Author(s): P. Nagaveni, Sirisha. S, C. Appa Rao.

Email(s): anjalisiri20@gmail.com

DOI: 10.52711/2231-5713.2021.00043   

Address: P. Nagaveni*, Sirisha. S, C. Appa Rao.
Sree Venkatsewara University, Tirupathi, Chitoor (Dis).
*Corresponding Author

Published In:   Volume - 11,      Issue - 4,     Year - 2021


ABSTRACT:
The aim of the present study involved the formulation and evaluation of mucoadhesive buccal tablets of anti-diabetic drug gliclazide, Mucoadhesive buccal tablets of Gliclazide are prepared by direct compression method In this present investigational research work the mucoadhesive buccal tablets of gliclazide is prepared separately employing 23 randomized full factorial design by using xanthan gum, carbopol-934, HPMC-E15LV, In this experimental model, target is to determine how the t90% of drug release and mucoadhesive characters can be affected by adjusting three parameters, concentration of polymers xanthan gum, HPMC-E15LV, carbopol-934, of the mucoadhesive buccal tablets. 2 3 full factorial studies were designed to determine the interaction of three independent variables at two levels (low and high level concentration) The tablets were tested for weight variation, hardness, surface pH, drug content uniformity, swelling index, mucoadhesion strength and in-vitro drug release study, Ex- vivo mucoadhesion time. From the drug release studies it was found that formulation H4 containing has good drug release when compared to other formulations.


Cite this article:
P. Nagaveni, Sirisha. S, C. Appa Rao. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Anti-Diabetic Drug using 23 Factorial Design. Asian Journal of Pharmacy and Technology. 2021; 11(4):261-6. doi: 10.52711/2231-5713.2021.00043

Cite(Electronic):
P. Nagaveni, Sirisha. S, C. Appa Rao. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Anti-Diabetic Drug using 23 Factorial Design. Asian Journal of Pharmacy and Technology. 2021; 11(4):261-6. doi: 10.52711/2231-5713.2021.00043   Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-4-1


REFERENCES:
1.    T. V. Thulasiramaraju, B. Tejeswar Kumar, A. Karthik Kumar, T. Naresh. Bucco- Adhesive Drug Delivery System: A Novel Drug Delivery Technique. Asian Journal of Research in Biological and Pharmaceutical Sciences, 2013; 1(1): 28-46.
2.    R. Jagadeeshwar Reddy, Maimuna Anjum and Mohammed Asif Hussain. A Comprehensive review on buccal drug delivery system: A review. American Journal of Advanced Drug Delivery, 2013; 1(13): 300-312.
3.    Sachin Shankar Lokhande, Sandeep S. Lahoti. Buccoadhesive Drug Delivery System: Need. A review. Asian Journal of Biomedical and Pharmaceutical Sciences, 2012; 2(14): 29-36.
4.    Vyas S P, Khar R K. Controlled drug delivery-concepts and advances. 1st edition, Vallabh Prakashan, New Delhi, 2002.
5.    Kumar S V, Rathinaraj B S, Bangale G S. Preformulation study of buccoadhesive monolayered tablets of carvedilol. International Journal Pharm Bio Sci., 2010; 1(2): 1-10.
6.    Gibson M. pharmaceutical preformulation and formulation. 10th ed. United States of America. IHS Health Group, 2004.
7.    Patel D B, Patel M M. Formulation and development of mucoadhesive tablet of diltiazem hydrochloride. Int J Pharm Bio Sci., 2010; 1(2): 1-14.
8.    United States Pharmacopeia. 26th ed. Port City Press, Baltimore, 2008; 231-32.
9.    Lachman L, Libberman HA, Kaing JL. The theory and practice of industrial pharmacy. 3rd ed. Mumbai. Varghese Publishing House, 1990; 296-302.
10.    S.S. Gite et al., Development and Evaluation of Mucoadhesive Tablets of Atenolol and its Β-Cyclodextrin Complex. Asian Journal of Biomedical and Pharmaceutical Sciences, 2014; 04: 25-32.
11.    Vaidya VM, Manvar JV, Mahjan NM, Sakarkar DM. Design and invitro evaluation of mucoadhesive buccal tablets of terbutaline sulphate. Int J PharmTech Res., 2009; 1(3): 588-97.

Recomonded Articles:

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar

DOI: 10.5958/2231-5713.2020.00046.X         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): AVS Madhu Latha, T Naga Ravikiran, J N Suresh Kumar

DOI: 10.5958/2231-5713.2019.00001.1         Access: Open Access Read More

Author(s): Kuldeep P. Waidya, S. Ramya Sri, T. Janaki

DOI: 10.5958/2231-5713.2019.00014.X         Access: Open Access Read More

Author(s): Ashish Kute, Prakash Goudanavar, Doddayya Hiremath, S.R. Reddy

DOI:         Access: Open Access Read More

Author(s): Jayesh S. Gharat, Yogita V. Dalvi

DOI: 10.5958/2231-5713.2018.00028.4         Access: Open Access Read More

Author(s): M. Kranthi Kumar Reddy, B. Narasimha Rao , K. Ravindra Reddy.

DOI:         Access: Open Access Read More

Author(s): Dasari Nirmala, Vaddi Harika, Muvvala Sudhakar

DOI: 10.52711/2231-5713.2022.00003         Access: Open Access Read More

Author(s): G. Sandhya Vani, Ch. Kiranmai, B. Hema Latha, K. Padmalatha

DOI: 10.52711/2231-5713.2023.00014         Access: Closed Access Read More

Author(s): Mali Hanmant S., Dhadde Gurunath S., Sapate Rohit B., Gidde Nikita D., Bagade Priyanka V.

DOI: 10.52711/2231-5713.2021.00037         Access: Open Access Read More

Author(s): Nikam Aaditya R., Nikum Ashwini C., Shaikh Azam Z.

DOI: 10.52711/2231-5713.2022.00044         Access: Open Access Read More

Author(s): Ashish Kumar, Dinesh Kumar Kashyap, Anjali, Kapil Kumar Verma

DOI: 10.52711/2231-5713.2024.00010         Access: Closed Access Read More

Author(s): Dinesh Kumar Kashyap, Ashish Kumar, Anjali, Kapil Kumar Verma

DOI: 10.52711/2231-5713.2024.00015         Access: Closed Access Read More

Author(s): Vaishnavi Inde, Mahesh Kadare, Vinod Matole, Doke Patil, Amar Anil, Harshada Patil, Sneha Kashid, Kajal wani

DOI: 10.52711/2231-5713.2024.00046         Access: Closed Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags