Author(s):
Dasari Nirmala, Vaddi Harika, Muvvala Sudhakar
Email(s):
Email ID Not Available
DOI:
10.52711/2231-5713.2022.00003
Address:
Dasari Nirmala, Vaddi Harika, Muvvala Sudhakar
Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University.
*Corresponding Author
Published In:
Volume - 12,
Issue - 1,
Year - 2022
ABSTRACT:
The aim of present study was to formulation and evaluation of Mucoadhesive buccal tablets of Resperidone. Mucoadhesive buccal tablets of Resperidone were prepared by direct compression method using polymers such as Karaya gum, tamarind gum, carbopol, and Sodium carboxy methyl cellulose. The Buccal tablets were evaluated for various physical, drug content uniformity, in-vitro drug release and drug- excipient interactions (FT-IR). FT-IR spectroscopic studies indicated that there were no drug-excipient interactions. The formulation F9 (containing 30mg of Carbopol) were found to be best formulation, which showed maximum drug release within 8 h. These formulations have showed good bioadhesion strength (18 gm).
Cite this article:
Dasari Nirmala, Vaddi Harika, Muvvala Sudhakar. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Resperidone. Asian Journal of Pharmacy and Technology. 2022; 12(1):13-9. doi: 10.52711/2231-5713.2022.00003
Cite(Electronic):
Dasari Nirmala, Vaddi Harika, Muvvala Sudhakar. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Resperidone. Asian Journal of Pharmacy and Technology. 2022; 12(1):13-9. doi: 10.52711/2231-5713.2022.00003 Available on: https://ajptonline.com/AbstractView.aspx?PID=2022-12-1-3
REFERENSES:
1. Shojaei HA. Buccal mucosa as a route for systemic drug delivery: A Review. J Pharml Sci.1998; 1(1): 15-30.
2. Mamatha Y et al. Buccal Drug delivery a Technical Approach, Journal of Drug Delivery Therapeutics. 2012; 2(2): 26-33.
3. Mamatha y et al. Buccal Drug delivery a Technical Approach. Journal of Drug Delivery Therapeutics. 2012; 2(2): 26-33.
4. Chinna Reddy P et al. A Review on Bioadhesive Buccal Drug Deliverysystems: Current Status of Formulation and Evaluation Methods. DARU. 2011; 19(6): 385-403.
5. Jayanna BK, Devaraj TD, Roopa KP, Nagendrappa G, Kumar HR, Gowda N. Spectrophotometric estimation of risperidone in tablets. Indian J Pharm Sci. 2014; 76(5): 452-455.
6. Thimmasetty J et al. Design and In vivo Evaluation of Carvedilol Buccal Mucoadhesive patch. Pak. J. Pharmsci. 2008; 21(3): 241-248.
7. A Semalty et al. Formulation and Evaluation of Muco adhesive Buccal Films of Enalapril maleate. Indian Journal of Pharmaceutical Sciences. 2010; 72(5): 571-575.
8. Milind et al. Formulation and Evaluation of Mucoadhesive Buccal Tablets Of Propranolol Prepared Using Natural Polymer. IJPSR. 2018; 9(7): 2905-2913.
9. Burak Celik et.al. Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation. Drug Des Devel Ther. 2017; (11), 3355-3365.
10. Ikinci G, Capan Y, Senel S and Dalkara T. In vitro / in vivo studies on buccal bioadhesive tablet formulation of carbamazepine. Pharmazie. 2000; 55(10): 762 – 765.
11. Ceschel GC, Maffei P, Lombardi BS and Ronchi C. Design and evaluation of buccal adhesive hydrocortisone acetate (HCA) tablets. Drug Deliv. 2001; 8(3): 161 - 171.
12. Varshosaz J and Dehghan Z. Development and characterization of buccoadhesive nifedipine tablets. Eur J Pharm Biopharm. 2002; 54(2): 135 – 141
13. Raghuraman S, Velrajan G, Jeyabalan B and Johnson BD. Design and evaluation of propranolol hydrochloride buccal films. Indian Journal of Pharmaceutical Sciences. 2002; 64(1): 32-35