Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System.

Nirav Patel; Jinal Patel; Moin Modasiya

Asian Journal of Pharmacy and Technology

ISSN

2231-5713 (Online)
2231-5705 (Print)

Submit Article

Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System.

Author(s): Nirav Patel, Jinal Patel, Moin Modasiya

Email(s): jinal1010@yahoo.com

DOI: Not Available

Address: Nirav Patel1, Jinal Patel*2, Moin Modasiya2.
1Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka.
2A.P.M.C. College of Pharmaceutical Education and Research, Motipura, Himatnagar-383001, Gujarat.
*Corresponding Author

Published In: Volume - 2, Issue - 2, Year - 2012

View HTML

View PDF

ABSTRACT:
The purpose of this investigation was to prepare a gastro retentive drug delivery system of Glipizide. Floating tablets of Glipizide were prepared employing different polymers like HPMC K100M, sodium alginate, Carbopol 940, and PVP K30 by effervescent technique. Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy, swelling study, dissolution studies and stability studies. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 16-24 hours. Stability studies were performed on the promising formulations at 40±2º C with 75±2 RH for 3 months.

Keywords:

Cite this article:
Nirav Patel, Jinal Patel, Moin Modasiya. Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System. Asian J. Pharm. Tech. 2(2): April-June 2012; Page 67-73.

Cite(Electronic):
Nirav Patel, Jinal Patel, Moin Modasiya. Formulation and In Vitro Evaluation of Glipizide as Floating Drug Delivery System. Asian J. Pharm. Tech. 2(2): April-June 2012; Page 67-73. Available on: https://ajptonline.com/AbstractView.aspx?PID=2012-2-2-10

Recomonded Articles:

Physico-chemical Properties of Solid Drugs: A Review

Author(s): Manohar D. Kengar, Rohit S. Howal, Dattatray B. Aundhakar, Amit V. Nikam, Priyajit S. Hasabe

DOI: 10.5958/2231-5713.2019.00010.2 Access: Open Access Read More

Calculation of predominant drug release mechanism using Peppas-Sahlin model, Part-I (substitution method): A linear regression approach

Author(s): Ravindra Babu Baggi, Naveen Babu Kilaru

DOI: Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available
DOI: 10.5958/2231–5713