Author(s): Saluja Parmeet K, Jain Neelam, Jain Neetesh. Kumar

Email(s): parisalujakwd@gmail.com

DOI: 10.52711/2231-5713.2023.00006   

Address: Saluja Parmeet K1, Jain Neelam2, Jain Neetesh. Kumar3
1Research Scholar, Faculty of Pharmacy, Oriental University, Indore - 453555, MP. India.
2Department of Pharmaceutics, Faculty of Pharmacy, Oriental University, Indore - 453555, MP. India.
3Department of Pharmacology, Faculty of Pharmacy, Oriental University, Indore - 453555, MP. India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2023


ABSTRACT:
Nabumetone was used as a model drug in this study to construct and assess floating tablets. By adjusting the drug to polymer ratio to 1:1, 1:1.5, and 1:2, naproxen sodium floating tablets were made utilising the wet granulation method. As generating agents, sodium bicarbonate and citric acid are utilised. With isopropyl alcohol acting as the solvent, lactose is employed as diluents and PVP K30 as a granulating agent. The formulation of the granules was assessed for flow properties, and the tablets were made and assessed for physical characteristics, invitro buoyancy testing, and drug content. All of the formulations displayed values that were within the permitted range, demonstrating the high calibre of the manufactured tablets. A decrease in the density of the tablet below 1 and the emergence of buoyancy were noticed as a result of the gas created being confined and protected within the gel formed by the polymers. As the polymer to drug ratio increases, it was seen that the floating lag time in the formulations F1 to F6 decreased while the total floating duration increased. Drug release from the formulations made in a 1:1 ratio occurred at a higher rate and to a greater extent (i.e. F1, F4, and F7). The produced tablets underwent evaluations for uniformity, hardness, friability, drug content, in vitro buoyancy experiments, and dissolving investigations. In addition, the invitro release data were fitted to various kinetic models.


Cite this article:
Saluja Parmeet K, Jain Neelam, Jain Neetesh. Kumar. Formulation and Evaluation of Floating Tablet of Nabumetone. Asian Journal of Pharmacy and Technology. 2023; 13(1):29-3. doi: 10.52711/2231-5713.2023.00006

Cite(Electronic):
Saluja Parmeet K, Jain Neelam, Jain Neetesh. Kumar. Formulation and Evaluation of Floating Tablet of Nabumetone. Asian Journal of Pharmacy and Technology. 2023; 13(1):29-3. doi: 10.52711/2231-5713.2023.00006   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-1-6


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