Author(s): Jafar Ikbal Abedin, Fr. Sheeba

Email(s): jafarabedin8@gmail.com

DOI: 10.52711/2231-5713.2023.00023   

Address: Jafar Ikbal Abedin*, Fr. Sheeba
Department of Pharmaceutics, Mallige College of Pharmacy, Bangalore - 560090, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2023


ABSTRACT:
Oral modified or controlled dosage forms have always been validated to be a more effective opportunity than conventional or immediate release dosage forms. Controlled or modified drug transport systems provide several benefits of delivering a drug to the body in a specific way to reduce its undesirable side effects and maximize its profit. It also improves the therapeutic efficacy of the drug, decreases toxicity, and with better patient compliance and convenience. In the beyond few decades, microspheres have promised targeted or controlled delivery of drugs in the body which proved to be higher than the conventional drug delivery. It also used to deliver drugs, vaccines, antibiotics, and hormones in a controlled way. Interpenetrating polymer networks have gained a lot of interest in drug delivery systems due to their ease of modification during their synthesis and development state, which evolved novel physicochemical and mechanical properties within the formulation. Interpenetrating polymer network (IPN) systems use novel polymers which are synthesized through the interlacing of two independent polymers in a cross-linked form. The polymers used to formulate an IPN system are independently cross-linked or cross-linked to each other. The present review aims to summarize the IPNmicrospheres systems in terms of their merits, classification, mechanism, method of formulation, evaluation and recent advances in the research field of IPN microspheres.


Cite this article:
Jafar Ikbal Abedin, Fr. Sheeba. Ipnmicrospheres for Controlled Drug Delivery: An Overeview. Asian Journal of Pharmacy and Technology. 2023; 13(2):123-9. doi: 10.52711/2231-5713.2023.00023

Cite(Electronic):
Jafar Ikbal Abedin, Fr. Sheeba. Ipnmicrospheres for Controlled Drug Delivery: An Overeview. Asian Journal of Pharmacy and Technology. 2023; 13(2):123-9. doi: 10.52711/2231-5713.2023.00023   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-2-9


REFERENCE:
1.    Reddy S, Krishna KVM and Srikanth S: A review on microsphere for novel drug delivery system.Int. J. res. Pharm. Chem. 2013;3(4):763-7.
2.    EWLi, S.P, Kowalski C.R, Feld K.M, Grim W.M. Recent Advances in MicroencapsulationTechnology and Equipment, Drug Dev Ind. Pharm 1988;14:353-76.
3.    Mathew T, Devi S, Prasanth V, and Vinod B: NSAIDs as microspheres. Internet J. Pharmacol.2008;6(1):233-9.
4.    Gupta N, Srivastava AK. Interpenetrating polymer networks: A review on synthesis and properties. Polym Int 1994;35:109-18.
5.    Lohani A, Singh G, Bhattacharya SS, Verma A. Interpenetrating polymer networks as innovative drug delivery systems. J Drug Deliver 2014; pp.1-11.
6.    L. H. Sperling and R. Hu, “Interpenetrating polymer networks,”in Polymer Blends Handbook, L.A. Utracki, Ed., pp. 417–447, Springer, Dordrecht, The Netherlands, 2003.
7.    Banerjee S, Ray S and Maiti S. Interpenetrating polymer network (IPN): a novel biomaterial. Int JAppl Pharmac. 2010;2:28-34.
8.    Shivashankar M, Mandal BK. A review on interpenetrating polymer network. Int J Pharm PharmSci 2012;4(5):1-7.
9.    Kim SC, Sperling LH. Interpenetrating Networks (IPNs)around the world‐science and engineering. John Wiley andSons. Chichester, UK, 1997.
10.    Patri M, Reddy CV, Narasimhan C, Samui AB. Sequential interpenetrating polymer networkbased on styrene butadiene rubber and polyalkyl methacrylates. J Appl Polym Sci 2007;103:1120-6.
11.    Tang D, Zhang X, Liu L, Qiang L. Simultaneous and gradient IPN of polyurethane/vinyl ester resin: Morphology and mechanical properties. J Nanomater 2009;25:1-6.
12.    Karabanova LV, Mikhalovsky SV, Lloyd AW, Boiteux G, Sergeeva LM, Novikova TI, et al. Gradient semi-interpenetrating polymer networks based on polyurethane and poly (vinyl pyrrolidone). J Mater Chem 2005;15:499-507.
13.    Sperling LH, Chiu TW, Hartman CP, Thomas DA. Latex Interpenetrating polymer networks. Int J Polym Mater 1972;1:331-41.
14.    Lipatov YS, Karabanova LV. Gradient interpenetrating polymer networks. J Mater Sci 1995;30:1095-104.
15.    Ohlsson B, Hassander H, Törnell B. Blends and thermoplastic interpenetrating polymer networks of polypropylene and polystyrene-block-poly (ethylene-stat-butylene)-block-polystyrene triblock copolymer. 1: Morphology and structure-related properties. Polym Eng Sci 1996;36:501-10.
16.    Dragan ES. Design and applications of interpenetrating polymer network hydrogels. A review. Chem Eng J 2014;243:572-90.
17.    Wu X, He G, Gu S, Hu Z, Yao P. Novel interpenetrating polymer network sulfonated poly (phthalazinone ether sulfone ketone)/ polyacrylic acid proton exchange membranes for fuel cell. J Membr Sci 2007; 295: 80-7.
18.    Shidhaye S, Surve C, Dhone A, Budhkar T. Interpenetrating polymer network: An overview. Int J Res Rev Pharmacy Appl Sci; 2(4): 637-50.
19.    Singh P, Kumar SKS, Keerthi TS, Mani TT, Getyala A. Interpenetrating polymer network (IPN) microparticles and advancement in novel drug delivery system: a review. Pharm Sci Monitor 2012;3(1):
20.    Bhattacharya SS, Shukla S, Banerjee S, Chowdhury P, Chakraborty P, Ghosh A. Tailored IPN hydrogel bead of sodium carboxymethyl cellulose and sodium carboxymethyl xanthan gum for controlled delivery of diclofenac sodium. Polym Plast Technol Eng 2013;52:795-805.
21.    Kulkarni RV, Baraskar VV, Alange VV, Naikawadi AA, Sa B. Controlled release of an antihypertensive drug through interpenetrating polymer network hydrogel tablets of tamarind seed polysaccharide and sodium alginate. J Macromol Sci Part B 2013;52:1636-50.
22.    Su X, Chen B. Tough, resilient and pH-sensitive interpenetrating polyacrylamide/ alginate/ montmorillonite nanocomposite hydrogels. Carbohydr Polym 2018;197:497-507.
23.    Nita LE, Chiriac AP, Rusu AG, Bercea M, Diaconu A, Tudorachi N, et al. Interpenetrating polymer network systems based on poly(dimethylaminoethyl methacrylate) and a copolymer containing pendant spiroacetal moieties. Mater Sci Eng C Mater Biol Appl 2018;87:22-31.
24.    J. D. Kosmala, D. B. Henthorn, and L. Brannon-Peppas, “Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials,” Biomaterials, vol. 21, no. 20, pp. 2019– 2023, 2000.
25.    K. Landfester, “Synthesis of colloidal particles in miniemulsions,” Annual Review of Materials Research, vol. 36,pp. 231–279,2006.
26.    Ms. J.D. Walde, Mr. H. S. Kanhere.  Formulation and Evaluation of Interpenetrating polymer network Microspheres containing ritonavir.  Int J Pharm Res Sch. 2020;9(1):1-17.
27.    Ebru Kondolot Solak. Preparation and Characterization of IPN Microspheres for Controlled Delivery of Naproxen. J. Biomater. Nanobiotechnol 2011;2:445-53.
28.    Kassem AA, Marzouk MA, El-Adawy SA, Dawaba AM. Formulation, in-vitro and in-vivo evaluation of semi-interpenetrating polymer network (Semi-IPN) microspheres of ketorolac tromethamine. J Life Med 2013;1(3):48-54
29.    Bhattacharya SS, Mazahir F, Banerjee S, Verma A, Ghosh A. Preparation and in vitro evaluation of xanthan gum facilitated superabsorbent polymeric microspheres. Carbohydr Polymers 2013;1:64-72.
30.    Jain N, Banik A, Gupta A. Novel interpenetrating polymer network microspheres of lepidium sativum and poly (vinyl alcohol) for the controlled release of simvastatin. Int J Pharm Sci 2013; 5(1): 125-30.
31.    Ramakrishna P, Rao KM, Sekharnath KV, et al. Synthesis and characterization of Interpenetrating polymer network microspheres of acryl amide grafted carboxy methylcellulose and sodium alginate for controlled release of triprolidine hydrochloride monohydrate. J Appl Pharm Sci 2013;3(3):101-8.
32.    Bhardwaj V, Kumar S. Design and characterization of novel interpenetrating polymer network mucoadhesive microspheres of locust bean gum and pva for controlled release of metformin HCl. Int Pharm Sci 2012;2(2):115-21.
33.    Banerjee S, Siddiqui L, Bhattacharya SS, et al. Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application. Int J Biological Macromol 2012;50(1):198-206.
34.    YerriSwamy B, Prasad CV, Reedy CLN, Mallikarjuna B, Rao KC, Subha MCS. Interpenetrating polymer network microspheres of hydroxyl propyl methyl cellulose/poly (vinyl alcohol) for control release of ciprofloxacin hydrochloride. Cellulose 2011;18:349-57.
35.    Angadi SC, Manjeshwar LS, Aminabhavi TM. Stearic acid-coated chitosan-based interpenetrating polymer network microspheres: controlled release characteristics. Ind Engin Chem Res 2011; 50(8):4504-14.
36.    Solak EK. Preparation and characterization of ipn microspheres for controlled delivery of naproxen. J Biomater Nano Biotechnol 2011;2:445-53.
37.    Sekhar EC, Rao KSV, Raju RR. Chitosan/guar-gum-g-acrylamide semi IPN microspheres for controlled release studies of 5- Fluorouracil. J Appl Pharm Sci 2011;01(08):199-204.
38.    Banerjee S, Chaurasia G, Pal DK, Ghosh AK, Ghosh A, Kaity S. Investigation on cross-linking density for development of novel interpenetrating polymer network (IPN) based formulation. J Sci Ind Res 2010;69:777-84.
39.    Mundargi RC, Shelke NB, Babu VR, Patel P, Rangaswamy V, Aminabhavi TM. Novel thermo-responsive semi-interpenetrating network microspheres of gellan gum-poly (N-isopropylacrylamide) for controlled release of atenolol. J Appl Polymer Sci 2010;116(3):1832-41.
40.    Angadi SC, Manjeshwar LS, Aminabhavi TM. Interpenetrating polymer network blend microspheres of chitosan and hydroxyl ethyl cellulose for controlled release of isoniazid. Int J Biological Macromol 2010;47:171-9.
41.    Rokhade AP, Shelke NB, Patil SA, Aminabhavi TM. Novel interpenetrating polymer network microspheres of chitosan and methylcellulose for controlled release of theophylline. Carbohyd Polym 2007;69(4):678-87.
42.    Rokhade AP, Patil SA, Aminabhavi TM. Synthesis and characterization of semi-interpenetrating microspheres of acrylamide grafted dextran and chitosan for controlled release of acyclovir. Carbohyd Polym 2007;67:605-13.
43.    Lee PI: Initial concentration distribution as a mechanism for regulating drug release from diffusion controlled and surface erosion-controlled matrix systems. J Control Release 1986;4:1–7.
44.    Xichen Zhang, Urs P. Wyss, David Pichora, Brian Amsden and Mattheus F.A. Goosen: Controlled release of albumin from biodegradable poly(DL-lactide) cylinders. J Control Release 1993;25(1-2):61-69.
45.    Kurkuri MD, Aminabhavi TM. Poly (vinyl alcohol) and poly (acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. J Control Release 2004;96:9-20.
46.    Ekici S, Saraydin D. Interpenetrating polymeric network hydrogels forpotential gastrointestinal drug release. Polym Int 2007;56:1371-7.
47.    Kumar JR, Haritha N, Umadevi SK. Formulation and evaluation of HPMC/sodium alginate/carbopol based pioglitazone beads. Res J Pharm Biol Chem Sci 2012;18:815-23.
48.    Kaity S, Isaac J, Ghosh A. Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. Carbohydr Polym 2013;94:456-67.
49.    Banerjee S, Siddiqui L, Bhattacharya SS, Kaity S, Ghosh A, Chattopadhyay P, et al. Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application. Int J Biol Macromol 2012;50:198-206.
50.    Gil ES, Hudson SM. Effect of silk fibroin interpenetrating networks on swelling/deswelling kinetics and rheological properties of poly (N-isopropylacrylamide) hydrogels. Biomacromolecules 2007;8:258-64.
51.    Eldin MM, Omer AM, Wassel MA, Tamer TM. Novel smart pH sensitive chitosan grafted alginate hydrogel microcapsules for oral protein delivery: I. Preparation and characterization. Int J Pharm Sci 2015;7:320-6.
52.    Giri TK, Choudhary C, Alexander A, Ajazuddin, Badwaik H, Tripathy M, et al. Sustained release of diltiazem hydrochloride from cross-linked biodegradable IPN hydrogel beads of pectin and modified xanthan gum. Indian J Pharm Sci 2013;75:619-27.
53.    Vancaeyzeele C, Fichet O, Boileau S, Teyssié D. Polyisobutene poly(methylmethacrylate) interpenetrating polymer networks: Synthesis and characterization. Polymer 2006;47:2046-60.
54.    Chakraborty P, Parcha V, Chakraborty DD, Ghosh A. Comparative study on the predictability of statistical models (RSM and ANN) on the behavior of optimized buccoadhesive wafers containing loratadine and their in vivo assessment. Drug Deliv 2016;23:1016-27.
55.    Kaustubh V. Gavali, Manohar D. Kengar, Kiran V. Chavan, Vaishnavi P. Anekar, Naziya I. Khan. A Review on Microsphere and it’s Application. Asian J. Pharm. Res. 2019; 9(2): 123-129.
56.    Dhadde Gurunath S., Mali Hanmant S., Raut Indrayani D., Nitalikar Manoj M., Bhutkar Mangesh A. A Review on Microspheres: Types, Method of Preparation, Characterization and Application. Asian Journal of Pharmacy and Technology. 2021; 11(2):149-5.
57.    Wajid Ahmad, Jaza Quazi, Reshma Khan, Nadeem Ahmad, Nawed Ansari. A Comprehensive Review on Microspheres. Asian Journal of Pharmacy and Technology. 2022; 12(2):136-0.
58.    Mahendrasinh Raj, Lata Raj. Interpenetrating Polymer Network (IPNs). Asian J. Research Chem. 7(11): November, 2014; Page 970-974.
59.    Rajesh Mujoriya. A review on study of microsphere. Research J. Pharma. Dosage Forms and Tech. 2012; 4(2): 80-85.
60.    Rutuja K. More, Diksha S. Sonawane, Moreshwar P. Patil, Sanjay J. Kshirsagar. Rutuja K. More, Diksha S. Sonawane, Moreshwar P. Patil, Sanjay J. Kshirsagar. Res. J. Pharma. Dosage Forms and Tech.2018; 10(3): 193-199.
61.    A.G. Chintale, V.S. Kadam, K.S. Maske, D.B. Raut, S.V. Kale, S.D. Rai. Recent Advances in Microsphere Drug Delivery System: A Review. Research J. Pharm. and Tech. 6(3): March 2013; Page 307-312.
62.    Mali Snehal D., Khochage Swapna R., Nitalikar Manoj M., Magdum Chandrakant S. Microencapsulation: A Review. Research J. Pharm. and Tech. 6(9): September 2013; Page 954-961.
63.    Ashwin Kumar Saxena, Aditya Sharma, Navneet Verma. Microspheres as Therapeutically effective Multiparticulate Drug Delivery System: A Systemic Review. Research Journal of Pharmacy and Technology. 2021; 14(6):3461-0.
64.    Arti Mohan, Gnana Ruba Priya. Formulation and Evaluation of Interpenetrating Polymer Network Microparticles of Diclofenac Sodium. Research Journal of Pharmacy and Technology. 2022; 15(2):792-8.
65.    Deepak S. Kshirsagar, R. B. Saudagar. Microsphere: A Review. Research J. Topical and Cosmetic Sci. 2016; 7(1): 27-37.

Recomonded Articles:

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Wajid Ahmad, Jaza Quazi, Reshma Khan, Nadeem Ahmad, Nawed Ansari

DOI: 10.52711/2231-5713.2022.00023         Access: Closed Access Read More

Author(s): Chinmaya Keshari Sahoo, K. Satyanarayana, D. Venkata Ramana, Kanhu Charan Panda

DOI: 10.5958/2231-5713.2017.00034.4         Access: Open Access Read More

Author(s): Yogita. Chowdhary

DOI: 10.5958/2231-5713.2018.00002.8         Access: Open Access Read More

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): Rutuja Saurabh Shah

DOI: 10.52711/2231-5713.2021.00035         Access: Open Access Read More

Author(s): Dhadde Gurunath S., Mali Hanmant S., Raut Indrayani D., Nitalikar Manoj M., Bhutkar Mangesh A.

DOI: 10.52711/2231-5713.2021.00025         Access: Open Access Read More

Author(s): Girishchandra R., Mandake, Shital S. Shinde, Vishal Y. Belaskar, Asha M. Jagtap, Ganesh B. Vambhurkar, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00033.8         Access: Open Access Read More

Author(s): Vishwas R. Potphode, Amol S. Deshmukh, Vijay R. Mahajan

DOI:         Access: Open Access Read More

Author(s): Poonam R. Songire, Smita S. Aher, R. B. Saudagar

DOI: 10.5958/2231-5713.2015.00031.8         Access: Open Access Read More

Author(s): Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar

DOI: 10.5958/2231-5713.2020.00046.X         Access: Open Access Read More

Author(s): K. Vanitha. M. Venkataswamy, Sanam Niharika, Alluri Ramesh

DOI: 10.5958/2231-5713.2018.00011.9         Access: Open Access Read More

Author(s): Vanitha Kondi, Ramesh Alluri

DOI:         Access: Open Access Read More

Author(s): G. Baskar, J. Chandhuru, K. Sheraz Fahad, A.S. Praveen

DOI:         Access: Open Access Read More

Author(s): Basavaraj, Someswara Rao B, S.V Kulkarni, Pramod Patil , Chetan Surpur

DOI:         Access: Open Access Read More

Author(s): Arpit Gawshinde, Dinesh kumar Mishra, Neha Kamalpuria, Nadeem Farooqui, Surbhi Choursiya

DOI: 10.52711/2231-5713.2021.00036         Access: Open Access Read More

Author(s): Himansu Bhusan Samal, Itishree Jogamaya Das, Ch. Niranjan Patra, P. N. Murthy

DOI: 10.5958/2231-5713.2015.00036.7         Access: Open Access Read More

Author(s): Girishchandra R. Mandake, Shital S. Shinde, Omkar A. Patil, Manojkumar M. Nitalikar

DOI: 10.5958/2231-5713.2018.00040.5         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags