Author(s): Ashwini Shelke, Madhavi Shinde, Rajendra Mogal, Rahul Sable, Anil Jadhav

Email(s): shelke.ashwini2@gmail.com

DOI: 10.5958/2231-5713.2018.00016.8   

Address: Ashwini Shelke*, Madhavi Shinde1, Rajendra Mogal2, Rahul Sable3, Dr. Anil Jadhav4
1Department of Pharmaceutical Chemistry, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213
2Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213
3 Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213
4 Department of Pharmacognosy, Sandip Institute of Pharmaceutical Sciences, Nashik, India-422213
*Corresponding Author

Published In:   Volume - 8,      Issue - 2,     Year - 2018


ABSTRACT:
Two simple method was developed for the simultaneous determination of tenofovir alafenamide fumarate (TAF) and emtricitabine (EMT) in combined tablets. The method involves the Simultameous equation method (Method A) and Q- Absorabnce Method (Method B). Tenofovir (TEF) has ?max 260nm and Emtricitabine (EMT) shows ?max at 237nm and 280nm both. Tenofovir (TEF) and Emtricitabine (EMT) at their respective ?max 260 nm and 280nm shows linearity in a concentration range of 5-30 µg/mL and 5-30 µg/mL respectively. Method A employs formation and solving of simultaneous equation using 260nm and 280nm as two analytical wavelengths for both drugs using Distilled water. Method B employs measurement using 237nm (?max of EMI) and 251nm as Iso-absorptive Point.


Cite this article:
Ashwini Shelke, Madhavi Shinde, Rajendra Mogal, Rahul Sable, Anil Jadhav. Application of UV Spectrophotometric Methods for Simultaneous Estimation of Emtricitabine and Tenofovir Alafenamide Fumarate in Bulk. Asian J. Pharm. Tech. 2018; 8 (2):103-107 . doi: 10.5958/2231-5713.2018.00016.8


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DOI: 10.5958/2231–5713 


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