Swapna Velivela, Nikunja B Pati, B. Ravindra Babu
Swapna Velivela*, Nikunja B Pati, B. Ravindra Babu
Pulla Reddy Institute of Pharmacy, Domadugu (V), Gummadidala (M), Sangareddy Dist, Telangana 502313.
Volume - 11,
Issue - 3,
Year - 2021
Temozolomide is an anti-cancer drug; it was encapsulated in liposomal intravenous application. To avoid the side effects and to target the drug to the specific site, we have formulated liposomal formulation of Temozolomide. The liposomal were prepared by dried thin film hydration technique using rotary evaporator with drug and Soya phosphatidyl choline as carrier. The prepared liposomes were characterized for size, shape, % entrapment efficiency, in-vitro drug release and physical stability. The evaluated batches showed good physicochemical characteristics. The maximum encapsulation efficiency of Temozolomide was achieved with formulation TMZ 6 with 40.19% and the in-vitro drug release is 64.94%. Based on the results it can be concluded that TMZ 6 was selected as optimized formulation and the optimized formulation Optimized formulation follows zero order release kinetics and follow super case II transport when it applied to Korsmeyer-Pepps model for mechanism of drug release.
Cite this article:
Swapna Velivela, Nikunja B Pati, B. Ravindra Babu. Formulation development of Temozolomide liposomal formulation in the treatment of Glioma. Asian Journal of Pharmacy and Technology. 2021; 11(3):203-6. doi: 10.52711/2231-5713.2021.00033
Swapna Velivela, Nikunja B Pati, B. Ravindra Babu. Formulation development of Temozolomide liposomal formulation in the treatment of Glioma. Asian Journal of Pharmacy and Technology. 2021; 11(3):203-6. doi: 10.52711/2231-5713.2021.00033 Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-3-3
1. Rosen H and Abribat T. The rise and rise of drug delivery. Nat Rev Drug Discov. 4; 2005: 381-385.
2. Garg AK, Negi LM and Chauhan M. Gel containing ethosomal vesicles for transdermal delivery of aceclofenac. Int Jr Pharm Pharm Sci. 2; 2010: 102-108.
3. P Garidel, B Folting, I Schaller and A Kerth. The microstructure of the stratum corneum lipid barrier: mid-infrared spectroscopic studies of hydrated ceramide: palmitic acid: cholesterol model systems. Biophysical Chemistry. 150; 2010: 144–156.
4. Harrington JH, Lewanski CR and Stewart JSW. Liposomes as vehicle for targeted therapy of cancer. Clinical Oncology. 12; 2000: 16-24.
5. GE El Maghraby, BW Carry and AC Williams. Liposome and skin: from drug delivery to model membrane, Eur Jr Parm Sci. 34(4–5); 2008: 203–222.
6. Marie S, Janknegt and R Bakker-Woudenberg, Clinical use of liposomal and lipid-complexed amphotericin. B. Jr Antimicrob Chemother. 33; 1994: 907-91
7. Mamot C, Drummond DC, Hong K, Kirpotin DB and Park JW. Liposome-based approaches to overcome anticancer drug resistance. Drug Resist Update. 6; 2003: 271-9.
8. Sharma G, Anabousi S, Ehrhardt C and Ravi Kumar MNV, Liposomes as targeted drug delivery system in the treatment of breast cancer. Jr Drug Delivery. 14; 2006: 301-310.
9. C Chang and L Zhang. Cellulose-based hydrogels: Present status and application prospects. Carbohydrate Polymers. 2011; 84: 40–53.
10. Luigi Cattel, MN, Immordino, Silvia Arpicco and Flavio Rocco. Preparation, Characterization, Cytotoxicity and pharmacokinetics of liposomes containing lipophilic gemcitabine prodrugs. Jr Control Rel. 100; 2004: 331-346.
11. Sasmita AO, Wong YP and Ling AP. Biomarkers and therapeutic advances in glioblastoma multiforme. Asia-Pacific Journal of Clinical Oncology. 14(1); 2018: 40–51.
12. Farago AF, Yeap BY, Stanzione M, Hung YP, Heist RS and Marcoux JP. Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer. Cancer Discov. 9(10); 2019: 1372–1387.
13. Ramachandran M, Watwe and Jagdesh R Bellare. Manufacturing of liposomes; A Review. Current Sci. 68; 1995: 715-724.
14. Isabel M, Mimoso, Ana Paula G and Franciso. Liposomal formulation of netilmicin. Int Jr Pharm. 147; 1997: 109-117.
15. Moghimipour E and Handali S. Utilization of thin film method for preparation of celecoxib loaded liposomes. Adv Pharm Bull. 2(1); 2012: 93–98.
16. Fresta M, Villari A, Puglisi G and Cavallaro G. 5-FU various kinds of loaded liposomes, encapsulation efficacy, storage stability and fusogenic properties. Int Jr Pharm. 99; 1993: 145-156.
17. Chetanachan P, Akarachalanon P, Worawirunwong D, Dararutana P, Bangtrakulnonth A and Bunjop M. Ultrastructural Characterization of Liposomes Using Transmission Electron Microscope. Adv Mat Res. 55; 2008: 709–711.
18. Hamid A, Merchant M, Harris shoiab and Jaweria Tazeen. Once daily tablet formulation and In vitro release evalution of Cefpodoxime using HPMC. AAPS Pharm Sci Tech. 7(3); 2006: 78-88.
19. Harris Shoaib M, Jaweria Tazeen and Hamid A. Merchant. Evalution drug release kinetics from Ibuprofen Matrix tablets using HPMC. Pak Jr Pharm Sci 9(2); 2006: 119-124.
20. Korsmeyer RW and Gurny R, Peppas Mechanism of solute release from porous hydrophilic polymers. Ind Jr Phar Sci. 78(3); 1983: 25-35.