Author(s): Swapna Velivela, Nikunja B Pati, B. Ravindra Babu

Email(s): swapna.velivela@gmail.com

DOI: 10.52711/2231-5713.2021.00033   

Address: Swapna Velivela*, Nikunja B Pati, B. Ravindra Babu
Pulla Reddy Institute of Pharmacy, Domadugu (V), Gummadidala (M), Sangareddy Dist, Telangana 502313.
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2021


ABSTRACT:
Temozolomide is an anti-cancer drug; it was encapsulated in liposomal intravenous application. To avoid the side effects and to target the drug to the specific site, we have formulated liposomal formulation of Temozolomide. The liposomal were prepared by dried thin film hydration technique using rotary evaporator with drug and Soya phosphatidyl choline as carrier. The prepared liposomes were characterized for size, shape, % entrapment efficiency, in-vitro drug release and physical stability. The evaluated batches showed good physicochemical characteristics. The maximum encapsulation efficiency of Temozolomide was achieved with formulation TMZ 6 with 40.19% and the in-vitro drug release is 64.94%. Based on the results it can be concluded that TMZ 6 was selected as optimized formulation and the optimized formulation Optimized formulation follows zero order release kinetics and follow super case II transport when it applied to Korsmeyer-Pepps model for mechanism of drug release.


Cite this article:
Swapna Velivela, Nikunja B Pati, B. Ravindra Babu. Formulation development of Temozolomide liposomal formulation in the treatment of Glioma. Asian Journal of Pharmacy and Technology. 2021; 11(3):203-6. doi: 10.52711/2231-5713.2021.00033

Cite(Electronic):
Swapna Velivela, Nikunja B Pati, B. Ravindra Babu. Formulation development of Temozolomide liposomal formulation in the treatment of Glioma. Asian Journal of Pharmacy and Technology. 2021; 11(3):203-6. doi: 10.52711/2231-5713.2021.00033   Available on: https://ajptonline.com/AbstractView.aspx?PID=2021-11-3-3


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