Author(s): B. Hemalatha, P. Bhuvaneswari, G. Kalyani, N. Krishna Veni, K. Naga Durga, P. Yashwanthi, K. Padmalatha

Email(s): balahemalatha25@gmail.com

DOI: 10.52711/2231-5713.2023.00003   

Address: B. Hemalatha*1, P. Bhuvaneswari1, G. Kalyani1, N. Krishna Veni1, K. Naga Durga1, P. Yashwanthi1, K. Padmalatha2
1Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for women, Vijayawada.
2Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for women, Vijayawada.
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2023


ABSTRACT:
Losartan is used to treat high blood pressure (hypertension) and also used to lower the risk of stroke in certain people with heart disease. Therefore, the purpose of this study is to formulate mouth dissolving tablet of losartan potassium to improve its bioavailability, to attain fast onset of action and rise patient compliance. Owing to short bioavailability of 33% and to increase onset of action, fast dissolving tablets of Losartan Potassium were formulated using coprocessed superdisintegrants in order to improve the dissolution rate, in that way the bioavailability. The effect of concentration of the Croscarmellose sodium was studied by a set of three formulations (F1, F2, F3) with concentrations of 2%, 4% and 8% w/w respectively. Similarly, the impact of Sodium Starch Glycolate was studied by a set of three formulations (F4, F5 and F6) respectively. The formulation prepared with 8% w/w of superdisintegrant showed relatively rapid release of Losartan potassium when compared with other concentrations of Croscarmellose sodium and Sodium Starch Glycolate. The formulation prepared with Croscarmellose sodium had showed relatively fast release of Losartan Potassium when compared with Sodium Starch Glycolate. Three formulations (F7, F8 and F9) were prepared by including a combination of superdisintegrants (Co-processed Mixtures), Croscarmellose sodium and Sodium Starch Glycolate by direct compression method. Formulation containing Co-processed mixtures had less disintegration time as compared to the individual superdisintegrants. Subsequently, we can conclude that nature, concentration of the superdisintegrant in addition to combination of superdisintegrants (Co-processed) showed influence on the rate of dissolution.


Cite this article:
B. Hemalatha, P. Bhuvaneswari, G. Kalyani, N. Krishna Veni, K. Naga Durga, P. Yashwanthi, K. Padmalatha. Development of Fast Dissolving Tablets of Losartan Potassium using Novel Co-processed Superdisintegrants. Asian Journal of Pharmacy and Technology. 2023; 13(1):9-8. doi: 10.52711/2231-5713.2023.00003

Cite(Electronic):
B. Hemalatha, P. Bhuvaneswari, G. Kalyani, N. Krishna Veni, K. Naga Durga, P. Yashwanthi, K. Padmalatha. Development of Fast Dissolving Tablets of Losartan Potassium using Novel Co-processed Superdisintegrants. Asian Journal of Pharmacy and Technology. 2023; 13(1):9-8. doi: 10.52711/2231-5713.2023.00003   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-1-3


REFERENCES:
1.    Pragya Baghel, Amit Roy, Shashikant Chandrakar, Sanjib Bahadur. Fast Dissolving Drug Delivery Systems: A Brief Review. Research J. Pharm. and Tech. 2013; 6(6): 597 – 602.
2.    L. H. Reddy, Bijaya Ghosh and Rajneesh. Fast dissolving drug delivery systems: A review of the literature. Indian J. Pharm. Sci., 2002; 64(4): 331 - 336.
3.    RD Rahane, Punit R. Rachh. A review on fast dissolving tablet. Journal of Drug Delivery and Therapeutics 2018; 8(5): 50 – 55.
4.    Ravi Kumar, Amit Kumar Rai, Navneet Kumar Verma, D. K Vishwakrma. Fast dissolving drug delivery system: Innovative strategies for drug application. International Journal of Pharmaceutics & Drug Analysis 2017; 5(7): 219 – 228.
5.    Deepak Heer, Geeta Aggarwal and S.L. Hari Kumar. Recent trends of fast dissolving drug delivery system - an overview of formulation technology. Pharmacophore 2013; 4(1): 1 - 9.
6.    Vishali T, Damodharan N. Orodispersible Tablets: A Review. Research J. Pharm. and Tech 2020; 13(5): 2522-2529.
7.    Sachin Gholve, Amar Kaware, Sanjay Thonte, Dattahari Kaudewar and Omprakash Bhusnure. Orodispersible tablets: A systematic review. World Journal of Pharmaceutical Research 2018; 7(6): 152 – 165.
8.    Anupam Roy. Orodispersible tablets: A review. Asian J Pharm Clin Res 2016; 9(1): 19 – 26.
9.    Ankit A., Kiran Kumar G. B., Madhu B. K. Formulation and evaluation of orodispersible tablets of dimenhydrinate by using co-processed superdisintegrants. Kathmandu University Journal of Science, Engineering and Technology 2016; 12(1): 23 – 33.
10.    Nitin K Kapse, Vilas P Bharti, Arunadevi S Birajdar, Anirudha V Munde, Pranita P Panchal. Co-Processed Superdisintegrants: Novel Technique for Design Orodispersible Tablets. Journal of Innovations in Pharmaceuticals and Biological Sciences 2015; 2 (4): 541 – 555.
11.    Abha and Loveleen Preet Kaur. Superdisintegrants: An arising exemplar in orodispersible tablets. International Journal of Drug Research and Technology 2015; 5(1): 01 -12.
12.    Rajasekhar Poonuru, Rohini Cheruku, Pavan Juluri, Khadeera Jabeen, Swetha Sreeramula, Sneha Bandari, Akhila Madupu. Formulation and evaluation of orodispersible tablets of lamotrigine using discrete super disintegrants and coprocessed excipients. International Journal of Pharmacy and Pharmaceutical Sciences 2020; 12(6): 28 – 35.
13.    Rakesh Pahwa and Nisha Gupta. Superdisintegrants in the development of orally disintegrating tablets: A review. International Journal of Pharmaceutical Sciences and Research 2011; 2(11): 2767 – 2780.
14.    Nani Parfati, Karina Citra Rani, Meilany. The effect of coprocessed superdisintegrants ratio (crospovidone - sodium starch glycolate) to the physicochemical characteristics of atenolol orally disintegrating tablets. Asian J Pharm Clin Res 2018; 11(2): 318 – 324.
15.    Shally Sharma, Nimrata Seth, Naresh Singh Gill. Formulation and evaluation of fast dissolving tablets of buspirone using coprocessed superdisintegrants. International Journal of Current Pharmaceutical Research 2019; 11 (5): 31 – 37.
16.    Mukesh C. Gohel, Rajesh K. Parikh, Bansari K. Brahmbhatt, and Aarohi R. Shah. Preparation and Assessment of Novel Coprocessed Superdisintegrant Consisting of Crospovidone and Sodium Starch Glycolate: A Technical Note. AAPS Pharm Sci Tech 2007; 8 (1): 1 – 7.
17.    S. B Shirsand, M. S para, R. G Ramani, P. V. Swamy, D. Nagendra Kumar and M. V Rampure. Novel co-processed superdisintegrants in the design of fast dissolving tablets. International Journal of Pharm Tech Research 2010; 2 (1): 222 -227.
18.    S. Venkateswara Rao, K. Sravya, & K. Padmalatha. Formulation and Evaluation of Fast Dissolving Tablets of Atorvastatin Using Novel Co-Processed Excipients. J. Pharm. Sci. & Res. 2021; 13(8): 474 – 480.
19.    Ashok Thulluru, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana. Role of Co-Processed Superdisintegrants in Enhancing the Dissolution Rate of Nifedipine in Sublingual Tablets. Asian Journal of Pharmaceutical Research 2019; 9 (4): 253 – 259.
20.    Nehal Siddiqui M, G Garima and P K Sharma. Fast dissolving tablets: preparation, characterization and evaluation. International Journal of Pharmaceutical Sciences Review and Research 2010; 4(2): 87-96.
21.    Rakesh Pahwa and Nisha Gupta. Superdisintegrants in the Development of Orally Disintegrating Tablets: A Review. International Journal of Pharmaceutical Sciences and Research 2011; 2(11): 2767-80.
22.    Sharma S and G D Gupta. Formulation and characterization of fast dissolving tablet of Promethazine Theoclate. Asian J. Pharm. 2008; 2(1): 70 - 72.
23.    Gautam Singhvi, Mahaveer Singh. Review: In vitro Drug Release Characterization Models. International Journal of Pharmaceutical Studies and Research 2011; 2(1): 77 - 84.
24.    Kadria A. Elkhodairy, Maha A. Hassan, Samar A. Afifi. Formulation and optimization of orodispersible tablets of flutamide. Saudi Pharmaceutical Journal 2014; 22(1): 53 – 61.

Recomonded Articles:

Author(s): Abhishek K. Sah, Manmohan Singh Jangdey, Sanjay J. Daharwal

DOI:         Access: Open Access Read More

Author(s): Kanchan R. Pagar, Sarika V. Khandbahale

DOI: 10.5958/2231-5713.2019.00023.0         Access: Open Access Read More

Author(s): Ruchika Sharma, M. S. Ashawat, C. P. S Verma, Neha Kumari

DOI: 10.5958/2231-5713.2020.00039.2         Access: Open Access Read More

Author(s): Yogita. Chowdhary

DOI: 10.5958/2231-5713.2018.00002.8         Access: Open Access Read More

Author(s): Beedha. Saraswathi, Dr. T. Satyanarayana, K. Mounika, G. Swathi , K. Sravika, M. Mohan Krishna

DOI: 10.5958/2231-5713.2018.00004.1         Access: Open Access Read More

Author(s): Sanjay Kshirsagar, Manisha Choudhari, Reshmi Sathyan, Shruti Dhore

DOI: 10.5958/2231-5713.2019.00024.2         Access: Open Access Read More

Author(s): Abhishek S. Pujari, Nitin A. Gaikwad, Indrajeet V. Mane, Ganesh B. Vambhurkar, Pravin P. Honmane

DOI: 10.5958/2231-5713.2018.00019.3         Access: Open Access Read More

Author(s): Nirmala Rangu, B. Chaitanya Kumari, Ganesh Akula, A Jaswanth

DOI: 10.5958/2231-5713.2018.00001.6         Access: Open Access Read More

Author(s): Anju govind, Manjunath B Menden, Ravikumar, Simila1, Mercy, Narayana Swamy VB

DOI: 10.5958/2231-5713.2016.00013.1         Access: Open Access Read More

Author(s): Himanshu Deshmkh, Chandrashekhara S., Nagesh C., Amol Murade, Shridhar Usgaunkar.

DOI:         Access: Open Access Read More

Author(s): Pawar P.B., M.P. Wagh, S.N. Bhandare

DOI:         Access: Open Access Read More

Author(s): Girishchandra R., Mandake, Shital S. Shinde, Vishal Y. Belaskar, Asha M. Jagtap, Ganesh B. Vambhurkar, Manoj M. Nitalikar

DOI: 10.5958/2231-5713.2018.00033.8         Access: Open Access Read More

Author(s): Vishwas R. Potphode, Amol S. Deshmukh, Vijay R. Mahajan

DOI:         Access: Open Access Read More

Author(s): Yogita Rayate, Shrinivas Mohite, Shital Shewale, Aishwarya Patil

DOI: 10.5958/2231-5713.2019.00005.9         Access: Open Access Read More

Author(s): Madan Singh, Prashant Soni, Neeraj Upmanyu , Yogesh Shivhare

DOI:         Access: Open Access Read More

Author(s): Sarjavalagi Vishal Gopal, Prabhat Kumar Chaurasia, Harshitha Arun Pardhe, Singh Suryansh Santosh, Narayan Sah Sonar

DOI: 10.5958/2231-5713.2020.00046.X         Access: Open Access Read More

Author(s): Vanitha Kondi, Ramesh Alluri

DOI:         Access: Open Access Read More

Author(s): Jangam Payal R, Thombre Nilima A, Gaikwad Pallavi N

DOI: 10.5958/2231-5713.2017.00027.7         Access: Open Access Read More

Asian Journal of Pharmacy and Technology (AJPTech.) is an international, peer-reviewed journal, devoted to pharmaceutical sciences...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2231–5713 


Recent Articles




Tags