Author(s): G. Kumaraswamy, Gandla Lalitha, K. Swetha, R. Suthakaran, G. Ramesh Babu

Email(s): Kumaraswamy.gandla@gmail.com

DOI: Not Available

Address: G. Kumaraswamy1*, Gandla Lalitha4, K. Swetha2, R. Suthakaran2, G. Ramesh Babu3
1Research Scholar, Department of Pharmaceutical Analysis, Jawaharlal Nehru Technological University Kakinada, Kakinada - 533 003-Andhra Pradesh, India.
2Department of Pharmaceutical analysis and QA, Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad-500097.Telangana.
3Chaithanya College of Pharmacy, Markapur, Prakasham (Dist). A.P. India
4Chilkur Balaji College of Pharmacy, Aziz Nagar, Hyderabad, Telangana.
*Corresponding Author

Published In:   Volume - 4,      Issue - 4,     Year - 2014


ABSTRACT:
The present work deals with the development of a precise, accurate, simple, specific, reliable and less time consuming RP-HPLC method for the estimation of Pseudoephedrine and Terfinadine tablets .The chromatographic separation was achieved on a Inertsil C18 ODS (4.6 x 250mm, 5µm) with a mobile phase combination of methanol and water (50:50) v/v at a flow rate of 1.0 ml/min, and the detection was carried out by using PDA detector at 290 nm. Ambient column temperature has maintained. The total run time was 10mins.The retention time of Pseudoephedrine and Terfinadine were found to be 2.9 min. and 3.5 min. respectively. The performance of the method was validated according to the present ICH guidelines.


Cite this article:
G. Kumaraswamy, Gandla Lalitha, K. Swetha, R. Suthakaran, G. Ramesh Babu. A Validated RP-HPLC Method for Simultaneous Estimation of Pseudoephedrine and Terfinadine in its Bulk and Pharmaceutical Dosage forms. Asian J. Pharm. Tech. 2014; Vol. 4: Issue 4, Oct.-Dec., Pg 200-204.


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DOI: 10.5958/2231–5713 


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