Author(s): Virani Paras, Sojitra Rajanit, Savaj Bhadresh, Raj Hashumati, Jain Vineet, Patel Kalpesh, SutariyaVishnu

Email(s): parasvirani@gmail.com

DOI: 10.5958/2231-5713.2015.00025.2   

Address: Virani Paras1,2*, Sojitra Rajanit1, Savaj Bhadresh1, Raj Hashumati1, Jain Vineet1, Patel Kalpesh1, SutariyaVishnu1
1Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat
2Research Scholar 2015, Gujarat Technological University, Gujarat
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2015


ABSTRACT:
A simple, accurate, rapid and precise reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of Irbesartan and Atorvastatin in synthetic mixture. Inertsil C18, 150 mm x 4.6 mm, 5 µm particle size in gradient mode with mobile phase Acetonitrile: 0.1% Formic acid (40: 60 v/v) and pH adjusted to 3.5 ± 0.1 with orthophosphoric acid was used. The flow rate was 1.0 ml/min and absorbance of individual component was measured at 262 nm. The retention times of Irbesartan and Atorvastatin were found to be 3.993 and 7.733 min, respectively. Linearity for Irbesartan and Atorvastatin was in the range of 400 - 800 and 50- 100µg/ml with correlation coefficient values 0.9995and 0.9994, the percentage recovery obtained was 99.88and 99.70 %, respectively.


Cite this article:
Virani Paras, Sojitra Rajanit, Savaj Bhadresh, Raj Hashumati, Jain Vineet, Patel Kalpesh, SutariyaVishnu. Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Irbesartan and Atorvastatin in Synthetic Mixture. Asian J. Pharm. Tech. 2015; Vol. 5: Issue 3, July- Sept. Pg 175-181. doi: 10.5958/2231-5713.2015.00025.2


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DOI: 10.5958/2231–5713 


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