ABSTRACT:
Traditional medicine is a set of knowledge, abilities, and procedures based on assumptions, beliefs, and experiences of traditional societies in order to preserve their health. In many undeveloped countries, many rural or indigenous people place a great importance on traditional herbal medicines. The World Health Organization estimates that 60% of rural Indians use. The usage of herbal supplements increased from 2.5% to 12% over the previous five years. India's transition from traditional to modern medicine has been made easier by the examination of novel drugs, especially those made using components derived from plants. Tannins, alkaloids, sugars, terpenoids, steroids, flavonoids, and phenols are a few of the chemical elements included in therapeutic plants that have a specific physiological impact on the human body. Natural therapeutic properties are just one benefit of medicinal plants; they also offer natural disease prevention. In this comprehensive review study research, we are making an effort to summarize, collect the number of plants, and identify their ethnopharmacological characteristics.
Cite this article:
Arjun Singh. Withania somnifera (L.) Ashwagandha: A Review on Ethnopharmacology, Phytochemistry, Biomedicinal and Traditional uses. Asian Journal of Pharmacy and Technology. 2023; 13(3):213-7. doi: 10.52711/2231-5713.2023.00038
Cite(Electronic):
Arjun Singh. Withania somnifera (L.) Ashwagandha: A Review on Ethnopharmacology, Phytochemistry, Biomedicinal and Traditional uses. Asian Journal of Pharmacy and Technology. 2023; 13(3):213-7. doi: 10.52711/2231-5713.2023.00038 Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-3-11
REFERENCES:
1. World Health Organization. WHO traditional medicine strategy: 2014-2023. World Health Organization, 2013.
2. World Health Organization. WHO global report on traditional and complementary medicine 2019. World Health Organization, 2019.
3. Qi, Zhang. "Who traditional medicine strategy. 2014-2023." Geneva: World Health Organization 188 (2013).
4. World Health Organization. "The regional strategy for traditional medicine in the Western Pacific (2011-2020)." (2012).
5. World Health Organization. Regional strategy for traditional medicine in the Western Pacific. Manila: WHO Regional Office for the Western Pacific, 2002.
6. Kasilo, Ossy MJ, and Jean‐Baptiste Nikiema. "World Health Organization perspective for traditional medicine." Novel Plant Bioresources: Applications in Food, Medicine and Cosmetics (2014): 23-42.
7. Zhang, Qi, Aditi Sharan, Stéphane Alexandre Espinosa, Daniel Gallego-Perez, and John Weeks. "The path toward integration of traditional and complementary medicine into health systems globally: The World Health Organization report on the implementation of the 2014–2023 strategy." The Journal of Alternative and Complementary Medicine 25, no. 9 (2019): 869-871.
8. Hajare, Ashok A, Sachin S Mali, Sonali S Gorde, Jyoti D Thorat, and Sachin S Salunkhe. “Narrative Review: A Rational Approach to Needle Free Insulin Technology,” 2014, 11.
9. Lakshmi, K. “Effectiveness of Nursing Care of Antenatal Mothers with Gestational Diabetes Mellitus.” Asian Journal of Nursing Education and Research 10, no. 3 (2020): 286.
10. Raju, Vidya, Jasmine Joy Bell, N. J. Merlin, and Shaiju S Dharan. “Ethno Pharmacological Uses of Artocarpus Altilis -A Review.” Asian Journal of Pharmaceutical Research 7, no. 4 (2017): 239.
11. Somwanshi, Sachin B., Punam D. Bairagi, and Kiran B. Kotade. “Study of Gestational Diabetes Mellitus: A Brief Review.” Asian Journal of Pharmaceutical Research 7, no. 2 (2017): 118.
12. Yousaf, Aqsa, and Sammia Shahid. “The Study of Anethum Graveolens L. (Dill) in the Case of Diabetes Mellitus (DM).” Asian Journal of Research in Pharmaceutical Science 10, no. 4 (2020): 248–56.
13. Chanda, D., Prieto-Lloret, J., Singh, A., Iqbal, H., Yadav, P., Snetkov, V., Aaronson, P.I., 2016. Glabridin-induced vasorelaxation: Evidence for a role of BKCa channels and cyclic GMP. Life Sciences 165, 26–34.
14. Gautam, Y., Dwivedi, S., Srivastava, A., Hamidullah, Singh, A., Chanda, D., Singh, J., Rai, S., Konwar, R., Negi, A.S., 2016. 2-(3′,4′-Dimethoxybenzylidene)tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species. RSC Adv. 6, 33369–33379.
15. Hamid, A.A., Hasanain, M., Singh, A., Bhukya, B., Omprakash, Vasudev, P.G., Sarkar, J., Chanda, D., Khan, F., Aiyelaagbe, O.O., Negi, A.S., 2014. Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin. Steroids 87, 108–118.
16. Hamid, A.A., Kaushal, T., Ashraf, R., Singh, A., Chand Gupta, A., Prakash, O., Sarkar, J., Chanda, D., Bawankule, D.U., Khan, F., Shanker, K., Aiyelaagbe, O.O., Negi, A.S., 2017. (22β,25R)-3β-Hydroxy-spirost-5-en-7-iminoxy-heptanoic acid exhibits anti-prostate cancer activity through caspase pathway. Steroids 119, 43–52.
17. Jain, S., Singh, A., Khare, P., Chanda, D., Mishra, D., Shanker, K., Karak, T., 2017. Toxicity assessment of Bacopa monnieri L. grown in biochar amended extremely acidic coal mine spoils. Ecological Engineering 108, 211–219.
18. Khwaja, S., Fatima, K., Hasanain, M., Behera, C., Kour, A., Singh, A., Luqman, S., Sarkar, J., Chanda, D., Shanker, K., Gupta, A.K., Mondhe, D.M., Negi, A.S., 2018. Antiproliferative efficacy of curcumin mimics through microtubule destabilization. European Journal of Medicinal Chemistry 151, 51–61.
19. Kumar, B.S., Ravi, K., Verma, A.K., Fatima, K., Hasanain, M., Singh, A., Sarkar, J., Luqman, S., Chanda, D., Negi, A.S., 2017. Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition. Bioorganic and Medicinal Chemistry 25, 1364–1373.
20. Mishra, D., Jyotshna, Singh, A., Chanda, D., Shanker, K., Khare, P., 2019. Potential of di-aldehyde cellulose for sustained release of oxytetracycline: A pharmacokinetic study. International Journal of Biological Macromolecules 136, 97–105.
21. Sathish Kumar, B., Kumar, A., Singh, J., Hasanain, M., Singh, A., Fatima, K., Yadav, D.K., Shukla, V., Luqman, S., Khan, F., Chanda, D., Sarkar, J., Konwar, R., Dwivedi, A., Negi, A.S., 2014a. Synthesis of 2-alkoxy and 2-benzyloxy analogues of estradiol as anti-breast cancer agents through microtubule stabilization. European Journal of Medicinal Chemistry 86, 740–751.
22. Sathish Kumar, B., Singh, Aastha, Kumar, A., Singh, J., Hasanain, M., Singh, Arjun, Masood, N., Yadav, D.K., Konwar, R., Mitra, K., Sarkar, J., Luqman, S., Pal, A., Khan, F., Chanda, D., Negi, A.S., 2014b. Synthesis of neolignans as microtubule stabilisers. Bioorganic & Medicinal Chemistry 22, 1342–1354.
23. Singh, A., Kumar, B.S., Alam, S., Iqbal, H., Shafiq, M., Khan, F., Negi, A.S., Hanif, K., Chanda, D., 2017. Diethyl-4,4ʹ-dihydroxy-8,3ʹ-neolign-7,7ʹ-dien-9,9ʹ-dionate exhibits AH activity in rats through increase in intracellular cGMP level and blockade of calcium channels. European Journal of Pharmacology 799, 84–93.
24. Singh, A., Kumar, B.S., Iqbal, H., Alam, S., Yadav, P., Verma, A.K., Khan, F., Shanker, K., Hanif, K., Negi, A.S., Chanda, D., 2019. AH activity of diethyl-4,4’-dihydroxy-8,3’-neolign-7,7’-dien-9,9’-dionate: A continuation study in L-NAME treated wistar rats. Eur. J. Pharmacol. 858, 172482.
25. Singh, A., Mohanty, I., Singh, J., Rattan, S., 2020. BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. American Journal of Physiology-Gastrointestinal and Liver Physiology 318, G23–G33.
26. Singh, A., Rattan, S., 2021. BDNF rescues aging-associated internal anal sphincter dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology 321, G87–G97.
27. Singh, A., Singh, J., Rattan, S., 2021. Evidence for the presence and release of BDNF in the neuronal and non‐neuronal structures of the internal anal sphincter. Neurogastroenterology& Motility.
28. Singh, Aastha, Fatima, K., Singh, Arjun, Behl, A., Mintoo, M.J., Hasanain, M., Ashraf, R., Luqman, S., Shanker, K., Mondhe, D.M., Sarkar, J., Chanda, D., Negi, A.S., 2015. Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule. European Journal of Pharmaceutical Sciences 76, 57–67.
29. Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S., 2016. Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des 88, 625–634.
30. Yadav, P., Iqbal, H., Kumar, K., Kumar, P., Mishra, D., Singh, A., Pal, A., Mukhopadhyay, P., Vamadevan, B., Singh, D., Negi, A.S., Chanda, D., 2022. 2-Benzyllawsone protects against polymicrobial sepsis and vascular hyporeactivity in swiss albino mice. European Journal of Pharmacology 917, 174757.
31. Manmohan, S., Arjun, S., Khan, S. P., Eram, S., &Sachan, N. K., 2012. Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy, 3, 31-36.
32. Singh A, Kumar BS, Alam S, Iqbal H, Shafiq M, Khan F, Negi AS, Hanif K, Chanda D. Corrigendum to "Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits AH activity in rats through increase in intracellular cGMP level and blockade of calcium channels" [Eur. J. Pharmacol. 799 (2017) 84-93]. Eur J Pharmacol. 2017 Jul 5;806:111. doi: 10.1016/j.ejphar.2017.04.033. Erratum for: Eur J Pharmacol. 2017 Mar 15;799:84-93. PMID: 28495016.
33. Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. "Food-drug interaction." International Journal of Pharmaceutical & Chemical Science 1, no. 1 (2012): 264-279.
34. Thanh-Hoang, N.-V.; Loc, N.; Nguyet, D.; Thien-Ngan, N.; Khang, T.; Cao, H.; Le, L. Plant Metabolite Databases: From Herbal Medicines to Modern Drug Discovery. J. Chem. Inf. Model. 2020, 60, 1101–1110.
35. Kumar, S.; Malhotra, R.; Kumar, D. Euphorbia hirta: Its chemistry, traditional and medicinal uses, and pharmacological activities. Pharmacogn. Rev. 2010, 4, 58–61.
36. Ramu,F.A.;Kumar,S.R.ScientificevaluationoftraditionallyknowninsulinplantCostusspeciesforthe treatment of diabetes in human. Int. J. Curr. Res. Biosci. Plant Biol. 2016, 3, 87–91.
37. Jayasri,M.A.;Gunasekaran,S.;Radha,A.;Mathew,T.L.AntidiabeticeffectofCostuspictusleavesinnormal and streptozotocin-induced diabetes rats. Int. J. Diabetes Metab. 2008, 16, 117–122.
38. Sidhu, A.K.; Wani, S.; Tamboli, P.S.; Patil, S.N. In Vitro Evaluation of Anti-Diabetic Activity of Leaf and Callus Extracts of Costus pictus. Int. J. Recent Sci. Res. 2014, 3, 1622–1625.
39. Prakash,K.; Harini,H.; Rao,A.; Rao,P.N. A review on Isulin plant(CostusigneusNak). Pharmacogn.Rev. 2014, 8, 67–72.
40. RadhaDevi, G.M. A Comprehensive Review On Costus Pictus D. Don.Int.J.Pharm.Sci.Res.2019, 10, 3187–3195.
41. Dhar, M.L., Dhar, M.M., Dhawan, B.N., Mehrotra, B.N., Ray, C. 1968. Screening of Indian plants for biological activity. Indian Journal of Experimental Biology 6 (4), 232-247.
42. Dhawan, B.N., Dubey, M.P., Mehrotra, B.N., Rastogi, R.P., Tandon, J.S. 1980. Screening of Indian plants for biological activity. Part 9. Indian Journal of Experimental Biology 18, 594-606.
43. ErmiAbriyani, Lia Fikayuniar. Screening Phytochemical, Antioxidant Activity and Vitamin C Assay from Bungo perak-perak (Begonia versicolarIrmsch) leaves. Asian J. Pharm. Res. 2020; 10(3):183-187.
44. Bhope SG, Kuber VV, Patil MJ, Ghosh VK. Validated HPTLC Method for the Quantitation of Andrographolide from Raw Material and Pharmaceutical Dosage Form. Asian J. Research Chem. 2(3): July-Sept., 2009, page 314-317.
45. Panlasigui, L.N., Panlilio, L.M., Madrid, J.C. 1995. Glycemic response in normal subjects to five different legumes commonly used in the Philippines. International Journal of Food Science and Nutrition 46 (2), 155-160.
46. Marles, R.J., Farnsworth, N.R. 1995. Antidiabetic plants and their active constituents. Phytomedicine 2, 133-189.
47. Kolhe Rohini C., Chaudhari Rajesh Y. A Review on Phytopharmacological Profile of Traditionally used medicinal plant Parkia biglandulosa (Mimosaceae). Asian J. Pharm. Res. 2020; 10(1): 34-38.
48. M. Ezhumalai, G. Hemalatha, J.P. Poornima, K.V. Pugalendi. Inhibition of Lactobacillus growth by amino acids and phytochemicals in the fermentation of curd by disc diffusion method. Asian J. Pharm. Res. 3(4): Oct. - Dec.2013; Page 189-193.
49. Chin, Y., Balunas, M., Chai, H., Kinghorn, A., 2006. Drug Discovery From Natural Sources. The AAPS Journal 08, E239–E239.
50. Nikhat F., Satyanarayana D., Shastri C.S., Rajni S., Sheikh A.S.. The Phytochemicals explored from the roots of Syzygiumcuminni (L) skeel assessed for Anti-hyperglycemic activity. Asian J. Research Chem. 6(10): October 2013; Page 920-925.
51. ThombreNilima, Shimpi Pranali2, Thete Madhura. Medicinal plant as a source of Antipyretic drug: A Review. Asian J. Pharm. Tech. 2021; 11(1):84-87.
52. Rahul Vikram Singh, Prabhakar Semwal, Taranjeet Kapoor. Medicinal Potential of Six Different Plant Species of Dehradun District, Uttarakhand. Asian J. Res. Pharm. Sci. 4(3): July-Sept. 2014; Page 134-139.
53. An Aqueous Extract of the Leaves of Chromolaena odorata Moderated Plasma Biochemical and Hematological Indices of Sub-Chronic Salt-Loaded Rats. Asian J. Pharm. Res. 4(1): Jan.-Mar. 2014; Page 24-35.
54. AK Meena, MM Rao, RP Meena, P Panda, Renu. Pharmacological and Phytochemical Evidences for the Plants of Wedelia Genus– A Review. Asian J. Pharm. Res. 1(1): Jan.-Mar. 2011; Page 07-12.
55. Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology; 12(4):349-0. doi: 10.52711/2231-5713.2022.00055