Author(s):
Arijita Singla, Varsha Singh, Komal Kumari, Sonam Pathak, Arjun Singh
Email(s):
arjunphar@gmail.com
DOI:
10.52711/2231-5713.2023.00042 
Address:
Arijita Singla1, Varsha Singh1, Komal Kumari1, Sonam Pathak1, Arjun Singh2*
1Department of Pharmacology, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author
Published In:
Volume - 13,
Issue - 3,
Year - 2023
ABSTRACT:
Cancer remains a global challenge for clinicians and researchers alike, with an increasing mortality rate. Despite enormous progress in anticancer drug discovery, there is a constant demand for novel therapeutic agents due to resistance to existing chemotherapeutic drugs and their adverse side effects. Natural anticancer drugs have been shown to be both effective and safe in the treatment of cancer. Over 70% of the earth's surface and 95% of its tropical biosphere are covered by the oceans. 50% of the Earth's biodiversity, or 34 out of the 36 phyla, is made up of marine organisms. The majority of oceanic organisms are members of the marine flora, which also includes sponges, seaweed, algae, cyanobacteria, and marine fungi. These marine sources have created a significant opportunity for the discovery of novel anticancer compounds due to their taxonomically diverse and biological characteristics. Numerous marine compounds with potent anticancer properties have recently been identified, and clinical studies have demonstrated their effectiveness. The majority of them are sulfated polysaccharides and polyphenols, which are renowned for their powerful antioxidant, antitumor. Thus, the current chapter focuses on natural anticancer compounds and their derivatives that are undergoing clinical trials.
Cite this article:
Arijita Singla, Varsha Singh, Komal Kumari, Sonam Pathak, Arjun Singh. Natural Marine Anticancer compounds and their derivatives used in Clinical Trials. Asian Journal of Pharmacy and Technology. 2023; 13(3):235-9. doi: 10.52711/2231-5713.2023.00042
Cite(Electronic):
Arijita Singla, Varsha Singh, Komal Kumari, Sonam Pathak, Arjun Singh. Natural Marine Anticancer compounds and their derivatives used in Clinical Trials. Asian Journal of Pharmacy and Technology. 2023; 13(3):235-9. doi: 10.52711/2231-5713.2023.00042 Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-3-15
REFERENCES:
1. Gautam, Yashveer, Sonam Dwivedi, Ankita Srivastava, Hamidullah, Arjun Singh, D. Chanda, Jyotsna Singh, Smita Rai, RiturajKonwar, and Arvind S. Negi. “2-(3′,4′-Dimethoxybenzylidene)Tetralone Induces Anti-Breast Cancer Activity through Microtubule Stabilization and Activation of Reactive Oxygen Species.” RSC Advances 6, no. 40 (April 5, 2016): 33369–79. https://doi.org/10.1039/C6RA02663J.
2. Hamid, A.A., Mohammad Hasanain, Arjun Singh, Balakishan Bhukya, Omprakash, Prema G. Vasudev, Jayanta Sarkar, et al. “Synthesis of Novel Anticancer Agents through Opening of Spiroacetal Ring of Diosgenin.” Steroids 87 (September 2014): 108–18. https://doi.org/10.1016/j.steroids.2014.05.025.
3. Jain, Shilpi, Arjun Singh, Puja Khare, D. Chanda, Disha Mishra, Karuna Shanker, and Tanmoy Karak. “Toxicity Assessment of Bacopa Monnieri L. Grown in Biochar Amended Extremely Acidic Coal Mine Spoils.” Ecological Engineering 108 (November 2017): 211–19. https://doi.org/10.1016/j.ecoleng.2017.08.039.
4. S. Lavanya, Nalini JeyavanthaSantha, Gowri Sethu. A descriptive study to assess the level of stress among women with selected type of cancer in Erode Cancer Centre at Erode. Asian J. Nur. Edu. & Research 4(3): July- Sept., 2014; Page 321-324.
5. Kumar, Balagani Sathish, Kusumoori Ravi, Amit Kumar Verma, Kaneez Fatima, Mohammad Hasanain, Arjun Singh, Jayanta Sarkar, Suaib Luqman, Debabrata Chanda, and Arvind S. Negi. “Synthesis of Pharmacologically Important Naphthoquinones and Anticancer Activity of 2-Benzyllawsone through DNA Topoisomerase-II Inhibition.” Bioorganic & Medicinal Chemistry 25, no. 4 (February 2017): 1364–73. https://doi.org/10.1016/j.bmc.2016.12.043.
6. Mishra, Disha, Jyotshna, Arjun Singh, D. Chanda, K. Shanker, and Puja Khare. “Potential of Di-Aldehyde Cellulose for Sustained Release of Oxytetracycline: A Pharmacokinetic Study.” International Journal of Biological Macromolecules 136 (September 2019): 97–105. https://doi.org/10.1016/j.ijbiomac.2019.06.043.
7. Sathish Kumar, B., Aastha Singh, Amit Kumar, Jyotsna Singh, Mohammad Hasanain, Arjun Singh, Nusrat Masood, et al. “Synthesis of Neolignans as Microtubule Stabilisers.” Bioorganic & Medicinal Chemistry 22, no. 4 (February 2014): 1342–54. https://doi.org/10.1016/j.bmc.2013.12.067.
8. Singh, Arjun, Ipsita Mohanty, Jagmohan Singh, and Satish Rattan. “BDNF Augments Rat Internal Anal Sphincter Smooth Muscle Tone via RhoA/ROCK Signaling and Nonadrenergic Noncholinergic Relaxation via Increased NO Release.” American Journal of Physiology-Gastrointestinal and Liver Physiology 318, no. 1 (January 1, 2020): G23–33. https://doi.org/10.1152/ajpgi.00247.2019.
9. Singh, Arjun, and Satish Rattan. “BDNF Rescues Aging-Associated Internal Anal Sphincter Dysfunction.” American Journal of Physiology-Gastrointestinal and Liver Physiology 321, no. 1 (July 1, 2021): G87–97. https://doi.org/10.1152/ajpgi.00090.2021.
10. Singh, Arjun, Jagmohan Singh, and Satish Rattan. “Evidence for the Presence and Release of BDNF in the Neuronal and Non‐neuronal Structures of the Internal Anal Sphincter.” Neurogastroenterology& Motility, February 24, 2021. https://doi.org/10.1111/nmo.14099.
11. Srivastava, Ankita, Kaneez Fatima, Eram Fatima, Arjun Singh, Aastha Singh, Aparna Shukla, Suaib Luqman, et al. “Fluorinated Benzylidene Indanone Exhibits Antiproliferative Activity through Modulation of Microtubule Dynamics and Antiangiogenic Activity.” European Journal of Pharmaceutical Sciences 154 (November 1, 2020): 105513. https://doi.org/10.1016/j.ejps.2020.105513.
12. Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S., 2016. Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des 88, 625–634.
13. Ravi Barot, T. Sivabalan. A study to evaluate the Quality of life in Head and Neck Cancer Patients admitted in Pravara Rural Hospital, Loni (Bk). Asian J. Nur. Edu. & Research 3(1): Jan.-March 2013; Page 21-24.
14. Manmohan, S., Arjun, S., Khan, S. P., Eram, S., &Sachan, N. K., 2012. Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy, 3, 31-36.
15. Singh A, Kumar BS, Alam S, Iqbal H, Shafiq M, Khan F, Negi AS, Hanif K, Chanda D. Corrigendum to "Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits AH activity in rats through increase in intracellular cGMP level and blockade of calcium channels" [Eur. J. Pharmacol. 799 (2017) 84-93]. Eur J Pharmacol. 2017 Jul 5; 806:111. doi: 10.1016/j.ejphar.2017.04.033. Erratum for: Eur J Pharmacol. 2017 Mar 15; 799:84-93. PMID: 28495016.
16. Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. "Food-drug interaction." International Journal of Pharmaceutical & Chemical Science 1, no. 1 (2012): 264-279.
17. Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology; 12(4):349-0. doi: 10.52711/2231-5713.2022.00055
18. Sampoornam. W. Hermeneutic circle focusing lived experience of Breast Cancer Survivorship- A Phenomenological Approach. Asian J. Nur. Edu. and Research 5(3): July- Sept.2015; Page 439-442.
19. Jisa George T, Kiran Batra. Cancer cervix; Preventive strategies; Pap smear screening. Asian J. Nur. Edu. and Research 5(3): July- Sept.2015; Page 420-424.
20. Bhagya Seela S, Shanmuga Raju P, Ezhilarasi R. Role of Nursing in Lymphoedema with Breast Cancer Patients. Asian J. Nur. Edu. and Research 5(4): Oct.- Dec.2015; Page 542-544.
21. Jisa George T, Kiran Batra. Beliefs and Attitude of Women Regarding Cervical Cancer Prevention and Screening in a Rural Community of Kerala. Asian J. Nur. Edu. and Research. 2016; 6(1): 7-10.
22. Pragya Pathak, Rajender Mahal, Adarsh Kohli, Vinod Nimbran. A Quasi Experimental Study to Evaluate the Effectiveness of Progressive Muscle Relaxation on Anxiety and Depression among Hospitalised Cancer Patients receiving Radiotherapy. Asian J. Nur. Edu. & Research 3(1): Jan.-March 2013; Page 42-46.
23. Arjun Patidar, S.C.Shivhare, Umesh Ateneriya, Sonu Choudhary. A Comprehensive Review on Breast Cancer. Asian J. Nur. Edu. & Research 2(1): Jan.-March 2012; Page 28-32.
24. J. Vijaya Raja Kumar, Uma M.. Effectiveness of Acupressure on improving the Quality of Sleep among Cancer Patients. Asian J. Nur. Edu. and Research 5(4): Oct.- Dec.2015; Page 513-517.
25. R. AdlinPon Joy. Effect of Foot Reflexology on Pain among Cancer Patients in Oncology Ward, Sri Ramakrishna Hospital, Coimbatore. Asian J. Nur. Edu. and Research 1(4): Oct-Dec. 2011; Page 107-108.
26. SedighehIranmanesh, Ala Shamsi. The Relationship between Type of Cancer and Parent's Psychosocial Risks. Asian J. Nur. Edu. and Research 4(4): Oct.- Dec., 2014; Page 495-501.
27. Anusha D Souza, Babu D, Gireesh GR. Assess Level of Risk of Cervical Cancer among Women in selected Community Area, Mangalore. Asian J. Nur. Edu. and Research 4(4): Oct.- Dec., 2014; Page 461-468.
28. A Case Study on Ovarian Cancer – Palliative Perspective. Asian J. Nur. Edu. and Research 5(3): July- Sept.2015; Page 446-448.
29. S. Shakila, S. Rajasankar, N. Kokilavani. A study to assess the Knowledge regarding Cervical Cancer among Women. Asian J. Nur. Edu. and Research 5(3): July- Sept.2015; Page 307-310.
30. Jasmine Kaur. An Exploratory Study to Assess the Quality of Life among Cancer Patients of District Bathinda, Punjab. Asian J. Nur. Edu. and Research 5(1): Jan.-March 2015; Page 18-22.
31. Jeenath Justin Doss K.. Effectiveness of Foot Massage on Level of Pain among Patients with Cancer. Asian J. Nur. Edu. & Research 4(2): April- June 2014; Page 228-231.
32. J. JaslinaGnanarani, Latha Venkatesan. The Palliative Care Needs, Quality Of Life and Coping Strategies among Oncology Patients And End Stage Organ Disease. Asian J. Nur. Edu. and Research. 2016; 6(3): 371-376.
33. Athar Javeth, R. G. Mathur, Molly Babu. A correlational survey to assess the level of stress, coping strategies, and quality of life of female cancer patients related to chemotherapy induced alopecia in Amala Cancer Hospital, Thrissur, Kerala. Asian J. Nur. Edu. and Research.2017; 7(1): 1-6.