Author(s):
Vikrant Dalwal, Palvi Sharma, Shivali, Ravinder Khatri, Monika Devi, Shilpa Thakur
Email(s):
vikrantdalwal692@gmail.com
DOI:
10.52711/2231-5713.2025.00001 
Address:
Vikrant Dalwal1*, Palvi Sharma2, Shivali3, Ravinder Khatri4, Monika Devi5, Shilpa Thakur6
1,3,4Gautam College of Pharmacy, Hamirpur Distt. Hamirpur, H.P, India.
2Abhilashi College of Pharmacy, Nerchowk, Distt. Mandi, H.P, India.
5Minerva College of Pharmacy, Indora, H.P, India.
6Shiva institute of pharmacy, Chandpur, Distt. Bilaspur, H.P, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 1,
Year - 2025
ABSTRACT:
Four quinoline derivatives are synthesized by reflux reaction of isatin with beta keto ester. The studies of docking results show good hydrogen bonding using Molegro virtual docker software (MVD). Mentioned compounds exhibit Mol dock score between the range -78.3595 to -124.166 more as compare with standard ligand chloramphenicol i.e., -99.4262. Synthesized compounds were then characterized by 1H- NMR and FTIR and tested in-vitro. The synthesized compounds show good antibacterial activity against bacteria (E. coli, Staphylococcus aureus, S. typhi, B. subtilis).
Cite this article:
Vikrant Dalwal, Palvi Sharma, Shivali, Ravinder Khatri, Monika Devi, Shilpa Thakur. Synthesis, Characterization, and Evaluation of Some Quinoline Derivatives as Possible Anti-Bacterial Agents. Asian Journal of Pharmacy and Technology. 2025; 15(1):1-5. doi: 10.52711/2231-5713.2025.00001
Cite(Electronic):
Vikrant Dalwal, Palvi Sharma, Shivali, Ravinder Khatri, Monika Devi, Shilpa Thakur. Synthesis, Characterization, and Evaluation of Some Quinoline Derivatives as Possible Anti-Bacterial Agents. Asian Journal of Pharmacy and Technology. 2025; 15(1):1-5. doi: 10.52711/2231-5713.2025.00001 Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-1-1
REFERENCES:
1. Kondaparla S, Agarwal P, Srivastava K, Puri SK, Katti SB. Design, synthesis and in vitro antiplasmodial activity of some bisquinolines against chloroquine-resistant strain. Chem Biol Drug Des. 2017 Jun; 89(6): 901–6.
2. Marella A, Tanwar OP, Saha R, Ali MR, Srivastava S, Akhter M, et al. Quinoline: A versatile heterocyclic. Saudi Pharm J [Internet]. 2013; 21(1):1–12. Available from: https://www.sciencedirect.com/science/article/pii/S1319016412000278
3. Jain S, Chandra V, Kumar Jain P, Pathak K, Pathak D, Vaidya A. Comprehensive review on current developments of quinoline-based anticancer agents. Arab J Chem [Internet]. 2019; 12(8): 4920–46. Available from: https://www.sciencedirect.com/science/article/pii/S1878535216301897
4. Krafts K, Hempelmann E, Skórska-Stania A. From methylene blue to chloroquine: a brief review of the development of an antimalarial therapy. Parasitol Res [Internet]. 2012; 111(1): 1–6. Available from: https://doi.org/10.1007/s00436-012-2886-x
5. Giamarellou H, Jackson GG. Antibacterial activity of cinoxacin in vitro. Antimicrob Agents Chemother. 1975; 7(5): 688–92.
6. Sisca TS, Heel RC, Romankiewicz JA. Cinoxacin. Drugs. 1983; 25(6): 544–69.
7. Jones RN, Fuchs PC. In vitro antimicrobial activity of cinoxacin against 2,968 clinical bacterial isolates. Antimicrob Agents Chemother. 1976; 10(1): 146–9.
8. Psomas G, Tarushi A, Efthimiadou EK, Sanakis Y, Raptopoulou CP, Katsaros N. Synthesis, structure and biological activity of copper(II) complexes with oxolinic acid. J Inorg Biochem [Internet]. 2006; 100(11): 1764–73. Available from: https://www.sciencedirect.com/science/article/pii/S0162013406001899
9. Chohan ZH, Supuran CT, Scozzafava A. Metal binding and antibacterial activity of ciprofloxacin complexes. J Enzyme Inhib Med Chem. 2005;20(3):303–7.
10. Fass RJ. In vitro activity of ciprofloxacin (Bay o 9867). Antimicrob Agents Chemother. 1983;24(4):568–74.
11. Chai Y, Liu M-L, Lv K, Feng L-S, Li S-J, Sun L-Y, et al. Synthesis and in vitro antibacterial activity of a series of novel gatifloxacin derivatives. Eur J Med Chem. 2011; 46(9): 4267–73.
12. amlendra Kumar, B. K. Singh. Synthesis, Characterization, and anti-Microbial activity of Some 4-Thiazolidinone Conjugatives. Asian J. Pharm. Ana. 2020; 10(4): 195-200.
13. M.C. Purohit, Anuj Kandwal, Reena Purohit, A.R. Semwal, Shama Parveen, Arun K. Khajuria. Antimicrobial Activity of Synthesized Zinc Oxide Nanoparticles using Ajuga bracteosa Leaf Extract. Asian Journal of Pharmaceutical Analysis. 2021; 11(4): 275-0.
14. ariyappan M., Bharathidasan R., Mahalingam R., Madhanraj P., Panneerselvam A., Ambikapathy V. Antibacterial Activity of Cardiospermum halicacabum and Melothria heterophylla. Asian J. Pharm. Res. 2011; 1(4): 111-113.
15. R. S. Kalkotwar, R. B. Saudagar. Design, Synthesis and anti microbial, anti-inflammatory, Antitubercular activities of some 2,4,5-trisubstituted imidazole derivatives. Asian J. Pharm. Res. 2013; 3(4): 159-165.
16. Hitesh V. Shahare, Rakesh D. Amrutkar. Synthesis, Characterization and Antimicrobial Activity of Diphenylamino Isoxazoline Derivatives. Asian J. Pharm. Res. 2018; 8(3): 148-150.
17. Govindarao Kamala, N. Srinivasan, K. Ravi Shankar, R. Suresh. Synthesis, Characterization and Antimicrobial Evaluation of N-Mannich Bases of (2- Substituted Phenyl) Benzimidazole Derivatives. Asian J. Pharm. Res. 2018; 8(2): 87-93.
18. K. Hemalatha, Joseph Selvin, K. Girija. Synthesis, In silico Molecular Docking Study and Anti-bacterial Evaluation of some Novel 4-Anilino Quinazolines. Asian J. Pharm. Res. 2018; 8(3): 125-132.
19. Dinesh D. Rishipathak, Trupti A. Jadhav, Sonal P. Tathe, Pavan B. Udavant. Microwave Assisted Synthesis and Pharmacological Evaluation of Few 4-Quinazolinone Derivatives. Asian J. Pharm. Res. 2019; 9(3):147-154.
20. Saema, Tabassum Wasim Ahmed, Peeyush Kumar Sharma, Imran Khan Pathan, Mamta Bhatia, Marhaba Khan. In vivo and In vitro Model for Evaluation of Anti-microbial activity: A Review. Asian Journal of Pharmaceutical Research. 2023; 13(3): 169-4.
21. Nikunj Patadiya, Vipul Vaghela. Design, in-silico ADME Study and molecular docking study of novel quinoline-4-on derivatives as Factor Xa Inhibitor as Potential anti-coagulating agents. Asian Journal of Pharmaceutical Research. 2022; 12(3): 207-1.
22. Ge Y, Yu N. Convenient one-step synthesis of quinoline-3, 4-dicarboxylate derivatives. Synth Commun. 2021;51(3):379–87.
23. Lv Q, Fang L, Wang P, Lu C, Yan F. A simple one-pot synthesis of quinoline-4-carboxylic acid derivatives by Pfitzinger reaction of isatin with ketones in water. Monatshefte für Chemie-Chemical Mon. 2013; 144(3): 391–4.